ID   ERYD_BRUA2              Reviewed;         316 AA.
AC   Q2YIQ4; Q578Y8; Q9ZB29;
DT   08-MAY-2019, integrated into UniProtKB/Swiss-Prot.
DT   07-FEB-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Erythritol catabolism regulatory protein EryD {ECO:0000305};
GN   Name=eryD {ECO:0000303|PubMed:10708387};
GN   OrderedLocusNames=BAB2_0369 {ECO:0000312|EMBL:CAJ12535.1};
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, ACTIVITY REGULATION,
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=2308;
RX   PubMed=10708387; DOI=10.1099/00221287-146-2-487;
RA   Sangari F.J., Aguero J., Garcia-Lobo J.M.;
RT   "The genes for erythritol catabolism are organized as an inducible operon
RT   in Brucella abortus.";
RL   Microbiology 146:487-495(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
CC   -!- FUNCTION: Represses the expression of the eryABCD operon, which is
CC       involved in erythritol catabolism. {ECO:0000269|PubMed:10708387}.
CC   -!- ACTIVITY REGULATION: Erythritol may act as an inducer, probably by
CC       binding to EryD and inhibiting its repressor activity.
CC       {ECO:0000269|PubMed:10708387}.
CC   -!- INDUCTION: Induced by erythritol and negatively autoregulated.
CC       {ECO:0000269|PubMed:10708387}.
CC   -!- DISRUPTION PHENOTYPE: Mutant shows increased transcription from the ery
CC       promoter. {ECO:0000269|PubMed:10708387}.
CC   -!- SIMILARITY: Belongs to the SorC transcriptional regulatory family.
CC       {ECO:0000305}.
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DR   EMBL; U57100; AAD11522.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12535.1; -; Genomic_DNA.
DR   RefSeq; WP_002965779.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q2YIQ4; -.
DR   SMR; Q2YIQ4; -.
DR   STRING; 359391.BAB2_0369; -.
DR   EnsemblBacteria; CAJ12535; CAJ12535; BAB2_0369.
DR   GeneID; 45053871; -.
DR   KEGG; bmf:BAB2_0369; -.
DR   PATRIC; fig|235.14.peg.919; -.
DR   HOGENOM; CLU_054506_0_0_5; -.
DR   OMA; SNEFITH; -.
DR   PhylomeDB; Q2YIQ4; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.10.10; -; 1.
DR   InterPro; IPR037171; NagB/RpiA_transferase-like.
DR   InterPro; IPR007324; Sugar-bd_dom_put.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   Pfam; PF04198; Sugar-bind; 1.
DR   SUPFAM; SSF100950; SSF100950; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..316
FT                   /note="Erythritol catabolism regulatory protein EryD"
FT                   /id="PRO_0000446540"
FT   DNA_BIND        23..42
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   316 AA;  33587 MW;  C7A09C1B60696D0B CRC64;
     MADADDSLAL RAAWLHFVAG MTQSAVAKRL GLPSVKAHRL IAKAVADGAV KVTIDGDITE
     CIDLENRLAD LYGLDYCEVA PDIGEEGLPL MALGHAGANF MRREIEHGDH EVIGIGHGRT
     LSAAVGYMPR VMANDLRFVS LLGGLTRNFA ANPHDVMHRI AEKTGMPAYV MPVPFFANTA
     EDREVLLAQR GVTTVFDMGC RAELKIVGIG TVDAQAQLVT SGMIELGEVE EIANLGGVGE
     MLGHFFNANG QWLETALTGR TIAASVENAD MSRIVALAGG LSKVDAIRAV LKSGRLYGLI
     TDERTAKALI GQPNGK