AGRB_STAEQ
ID AGRB_STAEQ Reviewed; 194 AA.
AC Q5HMY5;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784}; OrderedLocusNames=SERP1490;
OS Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus.
OX NCBI_TaxID=176279;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35984 / RP62A;
RX PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA Fraser C.M.;
RT "Insights on evolution of virulence and resistance from the complete genome
RT analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT strain.";
RL J. Bacteriol. 187:2426-2438(2005).
CC -!- FUNCTION: Essential for the production of a quorum sensing system
CC signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC system is responsible for the regulation of the expression of virulence
CC factor genes. Involved in the proteolytic processing of AgrD, the
CC precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_00784}.
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DR EMBL; CP000029; AAW54814.1; -; Genomic_DNA.
DR RefSeq; WP_001830005.1; NC_002976.3.
DR AlphaFoldDB; Q5HMY5; -.
DR SMR; Q5HMY5; -.
DR STRING; 176279.SERP1490; -.
DR MEROPS; C75.001; -.
DR EnsemblBacteria; AAW54814; AAW54814; SERP1490.
DR GeneID; 50018265; -.
DR KEGG; ser:SERP1490; -.
DR eggNOG; COG4512; Bacteria.
DR HOGENOM; CLU_098969_2_2_9; -.
DR OMA; MKFAIVY; -.
DR OrthoDB; 1320951at2; -.
DR Proteomes; UP000000531; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00784; AgrB; 1.
DR InterPro; IPR006741; AgrB.
DR Pfam; PF04647; AgrB; 1.
DR SMART; SM00793; AgrB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW Reference proteome; Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..194
FT /note="Accessory gene regulator protein B"
FT /id="PRO_0000168128"
FT TRANSMEM 44..64
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 80..100
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 107..127
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 142..162
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 163..183
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ SEQUENCE 194 AA; 22573 MW; 75076CD3DF62861A CRC64;
MKIIDKKIEQ FAQYLQRKNN LDHIQFLKIR LGMQVLAINI EKSIVVYGLA IIFHTFFYTL
LTHLSYFLIR RHAHGTHANS SLLCHIQNII FFIIFPYLII KLDINYFVLL SMALVGLIIT
ILYAPAATKK QPIPRRLVKR KKILSIFLYC TIVVISLVTK EPVNKLILFG VILESLTLLP
IFFPKEDINH GKHF
