ERYH_RHIME
ID ERYH_RHIME Reviewed; 255 AA.
AC Q92NH8;
DT 15-DEC-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=L-erythrulose-1-phosphate isomerase {ECO:0000250|UniProtKB:Q2YIQ6};
DE EC=5.3.1.33 {ECO:0000250|UniProtKB:Q2YIQ6};
DE AltName: Full=D-3-tetrulose-4-phosphate isomerase {ECO:0000250|UniProtKB:Q2YIQ6};
GN Name=eryH {ECO:0000250|UniProtKB:Q2YIQ6}; OrderedLocusNames=R02226;
GN ORFNames=SMc01614;
OS Rhizobium meliloti (strain 1021) (Ensifer meliloti) (Sinorhizobium
OS meliloti).
OC Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC Rhizobiaceae; Sinorhizobium/Ensifer group; Sinorhizobium.
OX NCBI_TaxID=266834;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11481430; DOI=10.1073/pnas.161294398;
RA Capela D., Barloy-Hubler F., Gouzy J., Bothe G., Ampe F., Batut J.,
RA Boistard P., Becker A., Boutry M., Cadieu E., Dreano S., Gloux S.,
RA Godrie T., Goffeau A., Kahn D., Kiss E., Lelaure V., Masuy D., Pohl T.,
RA Portetelle D., Puehler A., Purnelle B., Ramsperger U., Renard C.,
RA Thebault P., Vandenbol M., Weidner S., Galibert F.;
RT "Analysis of the chromosome sequence of the legume symbiont Sinorhizobium
RT meliloti strain 1021.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:9877-9882(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=1021;
RX PubMed=11474104; DOI=10.1126/science.1060966;
RA Galibert F., Finan T.M., Long S.R., Puehler A., Abola P., Ampe F.,
RA Barloy-Hubler F., Barnett M.J., Becker A., Boistard P., Bothe G.,
RA Boutry M., Bowser L., Buhrmester J., Cadieu E., Capela D., Chain P.,
RA Cowie A., Davis R.W., Dreano S., Federspiel N.A., Fisher R.F., Gloux S.,
RA Godrie T., Goffeau A., Golding B., Gouzy J., Gurjal M., Hernandez-Lucas I.,
RA Hong A., Huizar L., Hyman R.W., Jones T., Kahn D., Kahn M.L., Kalman S.,
RA Keating D.H., Kiss E., Komp C., Lelaure V., Masuy D., Palm C., Peck M.C.,
RA Pohl T.M., Portetelle D., Purnelle B., Ramsperger U., Surzycki R.,
RA Thebault P., Vandenbol M., Vorhoelter F.J., Weidner S., Wells D.H.,
RA Wong K., Yeh K.-C., Batut J.;
RT "The composite genome of the legume symbiont Sinorhizobium meliloti.";
RL Science 293:668-672(2001).
CC -!- FUNCTION: Catalyzes the isomerization of D-erythrulose-4P to L-
CC erythrulose-1P. {ECO:0000250|UniProtKB:Q2YIQ6}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-erythrulose 1-phosphate = D-erythrulose 4-phosphate;
CC Xref=Rhea:RHEA:49588, ChEBI:CHEBI:58002, ChEBI:CHEBI:90796;
CC EC=5.3.1.33; Evidence={ECO:0000250|UniProtKB:Q2YIQ6};
CC -!- PATHWAY: Carbohydrate metabolism; erythritol degradation.
CC {ECO:0000250|UniProtKB:Q2YIQ6}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:P9WG43}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P9WG43}.
CC -!- SIMILARITY: Belongs to the triosephosphate isomerase family.
CC {ECO:0000305}.
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DR EMBL; AL591688; CAC46805.1; -; Genomic_DNA.
DR RefSeq; NP_386332.1; NC_003047.1.
DR RefSeq; WP_010969784.1; NC_003047.1.
DR AlphaFoldDB; Q92NH8; -.
DR SMR; Q92NH8; -.
DR STRING; 266834.SMc01614; -.
DR EnsemblBacteria; CAC46805; CAC46805; SMc01614.
DR GeneID; 61603690; -.
DR KEGG; sme:SMc01614; -.
DR PATRIC; fig|266834.11.peg.3695; -.
DR eggNOG; COG0149; Bacteria.
DR HOGENOM; CLU_024251_2_3_5; -.
DR OMA; QEVCGAI; -.
DR UniPathway; UPA01066; -.
DR Proteomes; UP000001976; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0004807; F:triose-phosphate isomerase activity; IEA:InterPro.
DR GO; GO:0006094; P:gluconeogenesis; IEA:UniProtKB-KW.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-KW.
DR GO; GO:0006098; P:pentose-phosphate shunt; IEA:UniProtKB-KW.
DR CDD; cd00311; TIM; 1.
DR Gene3D; 3.20.20.70; -; 1.
DR InterPro; IPR013785; Aldolase_TIM.
DR InterPro; IPR035990; TIM_sf.
DR InterPro; IPR000652; Triosephosphate_isomerase.
DR InterPro; IPR020861; Triosephosphate_isomerase_AS.
DR PANTHER; PTHR21139; PTHR21139; 1.
DR Pfam; PF00121; TIM; 1.
DR SUPFAM; SSF51351; SSF51351; 1.
DR TIGRFAMs; TIGR00419; tim; 1.
DR PROSITE; PS00171; TIM_1; 1.
DR PROSITE; PS51440; TIM_2; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Gluconeogenesis; Glycolysis; Isomerase; Pentose shunt;
KW Reference proteome.
FT CHAIN 1..255
FT /note="L-erythrulose-1-phosphate isomerase"
FT /id="PRO_0000090277"
FT ACT_SITE 98
FT /note="Electrophile"
FT /evidence="ECO:0000250|UniProtKB:P9WG43"
FT ACT_SITE 171
FT /note="Proton acceptor"
FT /evidence="ECO:0000250|UniProtKB:P9WG43"
FT BINDING 177
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P9WG43"
FT BINDING 214
FT /ligand="substrate"
FT /evidence="ECO:0000250|UniProtKB:P9WG43"
SQ SEQUENCE 255 AA; 27623 MW; 2696EF571B14686E CRC64;
MSKSGLWVGT SWKMNKTLAE AMVFADGLAA ADDARDQRIQ RFVIPPFTAA RQVKERLKAT
SVKVGAQNMH WDDAGAWTGE ISPVMLSDCD LDIVELGHSE RREHFGETDR TVGLKTAAAV
KHGLVPLICI GETLAQREAG EADTVLKRQV EGAFAFLEGA ARKAPVLLAY EPVWAIGVNG
IPATADYADA RHRLIGEVAE RALGVKVPVL YGGSVNPQNC EELILQPHID GLFIGRSAWD
VGGYLDILQR VARAI