ID   ERYI_BRUA2              Reviewed;         151 AA.
AC   Q9ZB26; Q2YIQ7;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   10-APR-2019, sequence version 2.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=D-erythrulose-4-phosphate isomerase {ECO:0000305|PubMed:25453104};
DE            EC=5.3.1.34 {ECO:0000269|PubMed:25453104};
DE   AltName: Full=D-erythrose-4-phosphate isomerase {ECO:0000303|PubMed:25453104};
GN   Name=eryI {ECO:0000303|PubMed:25453104};
GN   Synonyms=rpiB {ECO:0000303|PubMed:25453104};
GN   OrderedLocusNames=BAB2_0366 {ECO:0000312|EMBL:CAJ12532.1};
OS   Brucella abortus (strain 2308).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Hyphomicrobiales;
OC   Brucellaceae; Brucella/Ochrobactrum group; Brucella.
OX   NCBI_TaxID=359391;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=10708387; DOI=10.1099/00221287-146-2-487;
RA   Sangari F.J., Aguero J., Garcia-Lobo J.M.;
RT   "The genes for erythritol catabolism are organized as an inducible operon
RT   in Brucella abortus.";
RL   Microbiology 146:487-495(2000).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2308;
RX   PubMed=16299333; DOI=10.1128/iai.73.12.8353-8361.2005;
RA   Chain P.S., Comerci D.J., Tolmasky M.E., Larimer F.W., Malfatti S.A.,
RA   Vergez L.M., Aguero F., Land M.L., Ugalde R.A., Garcia E.;
RT   "Whole-genome analyses of speciation events in pathogenic Brucellae.";
RL   Infect. Immun. 73:8353-8361(2005).
RN   [3]
RP   FUNCTION, CATALYTIC ACTIVITY, PATHWAY, AND DISRUPTION PHENOTYPE.
RC   STRAIN=2308;
RX   PubMed=25453104; DOI=10.1073/pnas.1414622111;
RA   Barbier T., Collard F., Zuniga-Ripa A., Moriyon I., Godard T., Becker J.,
RA   Wittmann C., Van Schaftingen E., Letesson J.J.;
RT   "Erythritol feeds the pentose phosphate pathway via three new isomerases
RT   leading to D-erythrose-4-phosphate in Brucella.";
RL   Proc. Natl. Acad. Sci. U.S.A. 111:17815-17820(2014).
CC   -!- FUNCTION: Catalyzes the isomerization of D-erythrulose-4P to D-
CC       erythrose-4P. Involved in the degradation pathway of erythritol, that
CC       allows B.abortus to grow on this compound as the sole carbon source.
CC       {ECO:0000269|PubMed:25453104}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrulose 4-phosphate = D-erythrose 4-phosphate;
CC         Xref=Rhea:RHEA:48784, ChEBI:CHEBI:16897, ChEBI:CHEBI:90796;
CC         EC=5.3.1.34; Evidence={ECO:0000269|PubMed:25453104};
CC   -!- PATHWAY: Carbohydrate metabolism; erythritol degradation.
CC       {ECO:0000269|PubMed:25453104}.
CC   -!- DISRUPTION PHENOTYPE: Cells lacking this gene do not grow on erythritol
CC       as sole carbon source, in contrast to wild-type.
CC       {ECO:0000269|PubMed:25453104}.
CC   -!- SIMILARITY: Belongs to the LacAB/RpiB family. {ECO:0000305}.
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DR   EMBL; U57100; AAD11525.1; -; Genomic_DNA.
DR   EMBL; AM040265; CAJ12532.1; -; Genomic_DNA.
DR   RefSeq; WP_002969302.1; NZ_KN046823.1.
DR   AlphaFoldDB; Q9ZB26; -.
DR   SMR; Q9ZB26; -.
DR   STRING; 359391.BAB2_0366; -.
DR   EnsemblBacteria; CAJ12532; CAJ12532; BAB2_0366.
DR   GeneID; 3827515; -.
DR   KEGG; bmf:BAB2_0366; -.
DR   PATRIC; fig|359391.11.peg.2318; -.
DR   HOGENOM; CLU_091396_1_0_5; -.
DR   OMA; ETHHANQ; -.
DR   UniPathway; UPA01066; -.
DR   Proteomes; UP000002719; Chromosome II.
DR   GO; GO:0016861; F:intramolecular oxidoreductase activity, interconverting aldoses and ketoses; IEA:UniProt.
DR   GO; GO:0005975; P:carbohydrate metabolic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.40.1400.10; -; 1.
DR   InterPro; IPR003500; RpiB_LacA_LacB.
DR   InterPro; IPR036569; RpiB_LacA_LacB_sf.
DR   Pfam; PF02502; LacAB_rpiB; 1.
DR   PIRSF; PIRSF005384; RpiB_LacA_B; 1.
DR   SUPFAM; SSF89623; SSF89623; 1.
DR   TIGRFAMs; TIGR00689; rpiB_lacA_lacB; 1.
PE   1: Evidence at protein level;
KW   Carbohydrate metabolism; Isomerase; Reference proteome.
FT   CHAIN           1..151
FT                   /note="D-erythrulose-4-phosphate isomerase"
FT                   /id="PRO_0000439209"
FT   ACT_SITE        65
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P37351"
FT   CONFLICT        145
FT                   /note="D -> Y (in Ref. 1; AAD11525)"
SQ   SEQUENCE   151 AA;  15709 MW;  4EB07B418D05FEAE CRC64;
     MKVAVAGDSA GEGLAKVLAD HLKDRFEVSE ISRTDAGADA FYANLSDRVA SAVLDGTYDR
     AILVCGTGIG VCIAANKVPG IRAALTHDTY SAERAALSNN AQIITMGARV IGAEVAKTIA
     DAFLAQTFDE NGRSAGNVNA INEVDAKYNK F