ER_DROME
ID ER_DROME Reviewed; 104 AA.
AC Q24337; A4V463; Q9W3B1;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Protein enhancer of rudimentary;
GN Name=e(r); ORFNames=CG1871;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=7896098; DOI=10.1093/genetics/138.4.1163;
RA Wojcik E., Murphy A.M., Fares H., Dang-Vu K., Tsubota S.I.;
RT "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the
RT rudimentary gene.";
RL Genetics 138:1163-1170(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP FUNCTION, AND PHOSPHORYLATION AT THR-18 AND SER-24.
RX PubMed=9074495; DOI=10.1016/s0378-1119(96)00701-9;
RA Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I.;
RT "The putative cell cycle gene, enhancer of rudimentary, encodes a highly
RT conserved protein found in plants and animals.";
RL Gene 186:189-195(1997).
CC -!- FUNCTION: Acts as an enhancer of the rudimentary gene. Has a role in
CC pyrimidine biosynthesis and the cell cycle.
CC {ECO:0000269|PubMed:7896098, ECO:0000269|PubMed:9074495}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically. Zygotic
CC expression is also seen in adult males. {ECO:0000269|PubMed:7896098}.
CC -!- PTM: Phosphorylated in vitro by casein kinase II (CK2).
CC {ECO:0000269|PubMed:9074495}.
CC -!- SIMILARITY: Belongs to the E(R) family. {ECO:0000305}.
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DR EMBL; L36921; AAA74593.1; -; mRNA.
DR EMBL; AE014298; AAF46421.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46422.1; -; Genomic_DNA.
DR EMBL; BT001470; AAN71225.1; -; mRNA.
DR PIR; S50341; S50341.
DR RefSeq; NP_001259363.1; NM_001272434.1.
DR RefSeq; NP_001259364.1; NM_001272435.1.
DR RefSeq; NP_001259365.1; NM_001272436.1.
DR RefSeq; NP_524662.1; NM_079923.3.
DR RefSeq; NP_727293.1; NM_167171.2.
DR AlphaFoldDB; Q24337; -.
DR SMR; Q24337; -.
DR BioGRID; 68740; 24.
DR DIP; DIP-19260N; -.
DR IntAct; Q24337; 13.
DR STRING; 7227.FBpp0071210; -.
DR iPTMnet; Q24337; -.
DR PaxDb; Q24337; -.
DR PRIDE; Q24337; -.
DR DNASU; 43951; -.
DR EnsemblMetazoa; FBtr0071266; FBpp0071209; FBgn0011586.
DR EnsemblMetazoa; FBtr0071267; FBpp0071210; FBgn0011586.
DR EnsemblMetazoa; FBtr0310067; FBpp0301768; FBgn0011586.
DR EnsemblMetazoa; FBtr0333604; FBpp0305781; FBgn0011586.
DR EnsemblMetazoa; FBtr0333605; FBpp0305782; FBgn0011586.
DR GeneID; 43951; -.
DR KEGG; dme:Dmel_CG1871; -.
DR CTD; 43951; -.
DR FlyBase; FBgn0011586; e(r).
DR VEuPathDB; VectorBase:FBgn0011586; -.
DR eggNOG; KOG1766; Eukaryota.
DR GeneTree; ENSGT00390000003316; -.
DR HOGENOM; CLU_125703_1_0_1; -.
DR InParanoid; Q24337; -.
DR OMA; RTWSDYE; -.
DR OrthoDB; 1512482at2759; -.
DR PhylomeDB; Q24337; -.
DR SignaLink; Q24337; -.
DR BioGRID-ORCS; 43951; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43951; -.
DR PRO; PR:Q24337; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0011586; Expressed in ovary and 30 other tissues.
DR ExpressionAtlas; Q24337; baseline and differential.
DR Genevisible; Q24337; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.2260.10; -; 1.
DR InterPro; IPR035912; EHR_sf.
DR InterPro; IPR000781; ERH.
DR PANTHER; PTHR12373; PTHR12373; 1.
DR Pfam; PF01133; ER; 1.
DR PIRSF; PIRSF016393; Enh_rudimentary; 1.
DR SUPFAM; SSF143875; SSF143875; 1.
DR PROSITE; PS01290; ER; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Phosphoprotein; Pyrimidine biosynthesis; Reference proteome.
FT CHAIN 1..104
FT /note="Protein enhancer of rudimentary"
FT /id="PRO_0000219348"
FT MOD_RES 18
FT /note="Phosphothreonine; by CK2"
FT /evidence="ECO:0000305|PubMed:9074495"
FT MOD_RES 24
FT /note="Phosphoserine; by CK2"
FT /evidence="ECO:0000305|PubMed:9074495"
SQ SEQUENCE 104 AA; 12188 MW; 294A50E7CF61B045 CRC64;
MSHTILLVQP GARPETRTYC DYESVNECME GVCKIYEEHL KRRNPNTPTI TYDISQLFDF
IDTMVDISCM VYQKSTNTYA PYNKDWIKEK IYVLLRQAAF SSNT
