ID   ER_DROVI                Reviewed;         104 AA.
AC   Q94554; B4MD96;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=Protein enhancer of rudimentary;
GN   Name=e(r); ORFNames=GJ15176;
OS   Drosophila virilis (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7244;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7896098; DOI=10.1093/genetics/138.4.1163;
RA   Wojcik E., Murphy A.M., Fares H., Dang-Vu K., Tsubota S.I.;
RT   "Enhancer of rudimentaryp1, e(r)p1, a highly conserved enhancer of the
RT   rudimentary gene.";
RL   Genetics 138:1163-1170(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX   PubMed=9074495; DOI=10.1016/s0378-1119(96)00701-9;
RA   Gelsthorpe M., Pulumati M., McCallum C., Dang-Vu K., Tsubota S.I.;
RT   "The putative cell cycle gene, enhancer of rudimentary, encodes a highly
RT   conserved protein found in plants and animals.";
RL   Gene 186:189-195(1997).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tucson 15010-1051.87;
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 genomes consortium;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Acts as an enhancer of the rudimentary gene. Has a role in
CC       pyrimidine biosynthesis and the cell cycle.
CC       {ECO:0000269|PubMed:9074495}.
CC   -!- SIMILARITY: Belongs to the E(R) family. {ECO:0000305}.
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DR   EMBL; U66868; AAC47488.1; -; Genomic_DNA.
DR   EMBL; CH940660; EDW58168.1; -; Genomic_DNA.
DR   PIR; A58158; A58158.
DR   RefSeq; XP_002059099.1; XM_002059063.2.
DR   AlphaFoldDB; Q94554; -.
DR   SMR; Q94554; -.
DR   STRING; 7244.FBpp0229593; -.
DR   EnsemblMetazoa; FBtr0435596; FBpp0392551; FBgn0014840.
DR   eggNOG; KOG1766; Eukaryota.
DR   HOGENOM; CLU_125703_1_0_1; -.
DR   InParanoid; Q94554; -.
DR   OMA; RTWSDYE; -.
DR   OrthoDB; 1512482at2759; -.
DR   PhylomeDB; Q94554; -.
DR   Proteomes; UP000008792; Unassembled WGS sequence.
DR   GO; GO:0005634; C:nucleus; IEA:EnsemblMetazoa.
DR   GO; GO:0006207; P:'de novo' pyrimidine nucleobase biosynthetic process; TAS:UniProtKB.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0006221; P:pyrimidine nucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.2260.10; -; 1.
DR   InterPro; IPR035912; EHR_sf.
DR   InterPro; IPR000781; ERH.
DR   PANTHER; PTHR12373; PTHR12373; 1.
DR   Pfam; PF01133; ER; 1.
DR   PIRSF; PIRSF016393; Enh_rudimentary; 1.
DR   SUPFAM; SSF143875; SSF143875; 1.
DR   PROSITE; PS01290; ER; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Phosphoprotein; Pyrimidine biosynthesis; Reference proteome.
FT   CHAIN           1..104
FT                   /note="Protein enhancer of rudimentary"
FT                   /id="PRO_0000219349"
FT   MOD_RES         18
FT                   /note="Phosphothreonine; by CK2"
FT                   /evidence="ECO:0000305"
FT   MOD_RES         24
FT                   /note="Phosphoserine; by CK2"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   104 AA;  12146 MW;  CCC98589D5D1B056 CRC64;
     MSHTILLVQP GARPETRTYC DYESVNECME GVCKIYEEHL KRRNPNTPTI TYDISQLFDF
     IDTLIDISCL VYQKSTNTYA PYNKDWIKEK IYVLLRQAAF SPNA