ID   ES16_MANSE              Reviewed;         145 AA.
AC   Q25481;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 69.
DE   RecName: Full=Ecdysteroid-regulated 16 kDa protein;
DE   Flags: Precursor;
GN   Name=ESR16;
OS   Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Bombycoidea;
OC   Sphingidae; Sphinginae; Sphingini; Manduca.
OX   NCBI_TaxID=7130;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=BH;
RA   Meszaros M.;
RL   Thesis (1995), University of Arizona, United States.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NPC2 family. {ECO:0000305}.
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DR   EMBL; U31456; AAB08704.1; -; mRNA.
DR   AlphaFoldDB; Q25481; -.
DR   SMR; Q25481; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0032367; P:intracellular cholesterol transport; IEA:InterPro.
DR   CDD; cd00916; Npc2_like; 1.
DR   InterPro; IPR014756; Ig_E-set.
DR   InterPro; IPR003172; ML_dom.
DR   InterPro; IPR033916; ML_Npc2-like.
DR   InterPro; IPR039670; NPC2-like.
DR   PANTHER; PTHR11306; PTHR11306; 1.
DR   Pfam; PF02221; E1_DerP2_DerF2; 1.
DR   SMART; SM00737; ML; 1.
DR   SUPFAM; SSF81296; SSF81296; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Glycoprotein; Secreted; Signal.
FT   SIGNAL          1..16
FT                   /evidence="ECO:0000255"
FT   CHAIN           17..145
FT                   /note="Ecdysteroid-regulated 16 kDa protein"
FT                   /id="PRO_0000019867"
FT   CARBOHYD        51
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        22..137
FT                   /evidence="ECO:0000250"
FT   DISULFID        90..97
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   145 AA;  15815 MW;  18DE78B55D4BFD49 CRC64;
     MLFYITVTVL LVSAQAKFYT DCGSKLATVQ SVGVSGWPEN ARECVLKRNS NVTISIDFSP
     TTDVSAITTE VHGVIMSLPV PFPCRSPDAC KDNGLTCPIK AGVVANYKTT LPVLKSYPKV
     SVDVKWELKK DEEDLVCILI PARIH