ID   ES1A_PELLE              Reviewed;          46 AA.
AC   P40843;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1995, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Esculentin-1A;
OS   Pelophylax lessonae (Pool frog) (Rana lessonae).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=45623;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BOND.
RC   TISSUE=Skin secretion;
RX   PubMed=8163497; DOI=10.1016/s0021-9258(17)32666-2;
RA   Simmaco M., Mignogna G., Barra D., Bossa F.;
RT   "Antimicrobial peptides from skin secretions of Rana esculenta. Molecular
RT   cloning of cDNAs encoding esculentin and brevinins and isolation of new
RT   active peptides.";
RL   J. Biol. Chem. 269:11956-11961(1994).
CC   -!- FUNCTION: Shows antibacterial activity against representative Gram-
CC       negative and Gram-positive bacterial species, and hemolytic activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   PIR; G53578; G53578.
DR   PDB; 2N6M; NMR; -; A=1-20.
DR   PDB; 5XDJ; NMR; -; A=1-20.
DR   PDBsum; 2N6M; -.
DR   PDBsum; 5XDJ; -.
DR   AlphaFoldDB; P40843; -.
DR   BMRB; P40843; -.
DR   SMR; P40843; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   GO; GO:0044179; P:hemolysis in another organism; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Cytolysis; Direct protein sequencing; Disulfide bond; Hemolysis; Secreted.
FT   CHAIN           1..46
FT                   /note="Esculentin-1A"
FT                   /id="PRO_0000165367"
FT   DISULFID        40..46
FT                   /evidence="ECO:0000269|PubMed:8163497"
FT   HELIX           5..19
FT                   /evidence="ECO:0007829|PDB:2N6M"
SQ   SEQUENCE   46 AA;  4803 MW;  CDD607B576AF98EF CRC64;
     GIFSKLAGKK IKNLLISGLK NVGKEVGMDV VRTGIDIAGC KIKGEC