ID   ES1_PELLE               Reviewed;          46 AA.
AC   P32414;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 60.
DE   RecName: Full=Esculentin-1;
OS   Pelophylax lessonae (Pool frog) (Rana lessonae).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Pelophylax.
OX   NCBI_TaxID=45623;
RN   [1]
RP   PROTEIN SEQUENCE, AND DISULFIDE BOND.
RC   TISSUE=Skin secretion;
RX   PubMed=8508915; DOI=10.1016/0014-5793(93)81384-c;
RA   Simmaco M., Mignogna G., Barra D., Bossa F.;
RT   "Novel antimicrobial peptides from skin secretion of the European frog Rana
RT   esculenta.";
RL   FEBS Lett. 324:159-161(1993).
CC   -!- FUNCTION: Shows antibacterial activity against representative Gram-
CC       negative and Gram-positive bacterial species, and hemolytic activity.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Brevinin subfamily. {ECO:0000305}.
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DR   PIR; S33731; S33731.
DR   AlphaFoldDB; P32414; -.
DR   SMR; P32414; -.
DR   GO; GO:0005576; C:extracellular region; IDA:UniProtKB.
DR   GO; GO:0050829; P:defense response to Gram-negative bacterium; IDA:UniProtKB.
DR   GO; GO:0050830; P:defense response to Gram-positive bacterium; IDA:UniProtKB.
DR   GO; GO:0044179; P:hemolysis in another organism; IDA:UniProtKB.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial; Cytolysis;
KW   Direct protein sequencing; Disulfide bond; Hemolysis; Secreted.
FT   CHAIN           1..46
FT                   /note="Esculentin-1"
FT                   /id="PRO_0000165366"
FT   DISULFID        40..46
FT                   /evidence="ECO:0000269|PubMed:8508915"
SQ   SEQUENCE   46 AA;  4888 MW;  FA5979B576AF855C CRC64;
     GIFSKLGRKK IKNLLISGLK NVGKEVGMDV VRTGIDIAGC KIKGEC