ID   ES1_RAT                 Reviewed;         266 AA.
AC   P56571; Q68FS5;
DT   15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 2.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=ES1 protein homolog, mitochondrial;
DE   Flags: Precursor;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PROTEIN SEQUENCE OF 40-50.
RC   STRAIN=Wistar; TISSUE=Heart;
RX   PubMed=10344264;
RX   DOI=10.1002/(sici)1522-2683(19990101)20:4/5<891::aid-elps891>3.0.co;2-2;
RA   Li X.P., Pleissner K.-P., Scheler C., Regitz-Zagrosek V., Salnikow J.,
RA   Jungblut P.R.;
RT   "A two-dimensional electrophoresis database of rat heart proteins.";
RL   Electrophoresis 20:891-897(1999).
RN   [3]
RP   PROTEIN SEQUENCE OF 115-139; 169-183 AND 222-231, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RC   STRAIN=Sprague-Dawley; TISSUE=Hippocampus, and Spinal cord;
RA   Lubec G., Afjehi-Sadat L., Chen W.-Q.;
RL   Submitted (JAN-2009) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000305}.
CC   -!- MISCELLANEOUS: By 2D-PAGE, the determined pI of this protein (spot P2)
CC       is: 8.9, its MW is: 25 kDa.
CC   -!- SIMILARITY: Belongs to the ES1 family. {ECO:0000305}.
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DR   EMBL; BC079380; AAH79380.1; -; mRNA.
DR   RefSeq; NP_001004225.1; NM_001004225.1.
DR   AlphaFoldDB; P56571; -.
DR   SMR; P56571; -.
DR   IntAct; P56571; 1.
DR   STRING; 10116.ENSRNOP00000001609; -.
DR   iPTMnet; P56571; -.
DR   PhosphoSitePlus; P56571; -.
DR   SwissPalm; P56571; -.
DR   jPOST; P56571; -.
DR   PaxDb; P56571; -.
DR   PRIDE; P56571; -.
DR   GeneID; 294326; -.
DR   KEGG; rno:294326; -.
DR   UCSC; RGD:1303003; rat.
DR   CTD; 28295; -.
DR   RGD; 1303003; RGD1303003.
DR   VEuPathDB; HostDB:ENSRNOG00000001211; -.
DR   eggNOG; ENOG502QQFM; Eukaryota.
DR   HOGENOM; CLU_072952_0_0_1; -.
DR   InParanoid; P56571; -.
DR   OMA; AQVQCFA; -.
DR   OrthoDB; 1204104at2759; -.
DR   PhylomeDB; P56571; -.
DR   TreeFam; TF329408; -.
DR   PRO; PR:P56571; -.
DR   Proteomes; UP000002494; Chromosome 20.
DR   Bgee; ENSRNOG00000001211; Expressed in heart and 20 other tissues.
DR   Genevisible; P56571; RN.
DR   GO; GO:0005739; C:mitochondrion; IBA:GO_Central.
DR   Gene3D; 3.40.50.880; -; 1.
DR   InterPro; IPR029062; Class_I_gatase-like.
DR   SUPFAM; SSF52317; SSF52317; 1.
PE   1: Evidence at protein level;
KW   Acetylation; Direct protein sequencing; Mitochondrion; Reference proteome;
KW   Transit peptide.
FT   TRANSIT         1..39
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000250"
FT   CHAIN           40..266
FT                   /note="ES1 protein homolog, mitochondrial"
FT                   /id="PRO_0000043354"
FT   MOD_RES         149
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         155
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         162
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         201
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         201
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         217
FT                   /note="N6-acetyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         221
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         221
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         231
FT                   /note="N6-acetyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   MOD_RES         231
FT                   /note="N6-succinyllysine; alternate"
FT                   /evidence="ECO:0000250|UniProtKB:Q9D172"
FT   CONFLICT        50
FT                   /note="C -> T (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   266 AA;  28173 MW;  033D1C13DFF8606F CRC64;
     MAAVRVLVSP RLASALLPLS GRHRTTSQRA AIHSSAPRPR ARVALVLSGC GVYDGTEIHE
     ASAILVHLSR GGAEVHIFAP DVPQMHVIDH TKGEPSEKES RNVLAESARI ARGKITNLAQ
     LSAANHDAAI FPGGFGAAKN LSTFAVDGKD CKVNKEVERV LKEFHGAKKP IGLCCIAPVL
     AAKVIKGVEV TVGHEQEEGG KWPYAGTAEA VKALGAKHCV KGVTEAHVDQ KNKVVTTPAF
     MCETELHHIH DGIGAMVKKV LELTGK