AGRB_STAIN
ID AGRB_STAIN Reviewed; 188 AA.
AC P61649;
DT 07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2004, sequence version 1.
DT 03-AUG-2022, entry version 54.
DE RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
OS Staphylococcus intermedius.
OC Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC Staphylococcus; Staphylococcus intermedius group.
OX NCBI_TaxID=1285;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Pei W., Ji G.;
RT "Staphylococcus intermedius agr gene locus.";
RL Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Essential for the production of a quorum sensing system
CC signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC system is responsible for the regulation of the expression of virulence
CC factor genes. Involved in the proteolytic processing of AgrD, the
CC precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC Rule:MF_00784}.
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DR EMBL; AY557375; AAS66745.1; -; Genomic_DNA.
DR RefSeq; WP_019167559.1; NZ_MWUY01000003.1.
DR AlphaFoldDB; P61649; -.
DR MEROPS; C75.001; -.
DR eggNOG; COG4512; Bacteria.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR HAMAP; MF_00784; AgrB; 1.
DR InterPro; IPR006741; AgrB.
DR Pfam; PF04647; AgrB; 1.
DR SMART; SM00793; AgrB; 1.
PE 3: Inferred from homology;
KW Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW Transmembrane; Transmembrane helix; Virulence.
FT CHAIN 1..188
FT /note="Accessory gene regulator protein B"
FT /id="PRO_0000168131"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 104..126
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 143..163
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT TRANSMEM 166..186
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ SEQUENCE 188 AA; 21324 MW; 63A94383ADEFD1F9 CRC64;
MLLIDNGIEK MALKLQQRQN LSHIEFLKVR LGMQVVVINT FKAIVTYGLA LLLNIFLYTL
IVHLTFLTLR TYSHGAHAKT SMLCHVQNIV AFVMLPWLIV QYDISFQFLL ILSLLSALIV
IKYAPAATKK RPIAPKKVKG LKIKSIIVFV LLMTIACIVP PPYNRFVVYG VLLQSFTLLP
IFSIKEEV
