ID   ES2JB_ODOJI             Reviewed;          37 AA.
AC   B3A0M9;
DT   31-OCT-2012, integrated into UniProtKB/Swiss-Prot.
DT   31-OCT-2012, sequence version 1.
DT   25-MAY-2022, entry version 13.
DE   RecName: Full=Esculentin-2JDb {ECO:0000303|PubMed:22917879};
OS   Odorrana jingdongensis (Jingdong frog) (Rana jingdongensis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Odorrana.
OX   NCBI_TaxID=431936;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, PROBABLE FUNCTION, SUBCELLULAR LOCATION, AND MASS
RP   SPECTROMETRY.
RC   TISSUE=Skin secretion {ECO:0000269|PubMed:22917879};
RX   PubMed=22917879; DOI=10.1016/j.jprot.2012.08.004;
RA   Liu J., Jiang J., Wu Z., Xie F.;
RT   "Antimicrobial peptides from the skin of the Asian frog, Odorrana
RT   jingdongensis: De novo sequencing and analysis of tandem mass spectrometry
RT   data.";
RL   J. Proteomics 75:5807-5821(2012).
CC   -!- FUNCTION: Has antibacterial activity against E.coli and S.aureus
CC       strains. {ECO:0000269|PubMed:22917879, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305|PubMed:22917879}.
CC   -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC       {ECO:0000305|PubMed:22917879}.
CC   -!- MASS SPECTROMETRY: Mass=3818.1154; Mass_error=0.0013;
CC       Method=Electrospray; Evidence={ECO:0000269|PubMed:22917879};
CC   -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC       Esculentin subfamily. {ECO:0000255}.
CC   -!- WEB RESOURCE: Name=The antimicrobial peptide database;
CC       URL="https://wangapd3.com/database/query_output.php?ID=01866";
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   AlphaFoldDB; B3A0M9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR   InterPro; IPR012521; Antimicrobial_frog_2.
DR   Pfam; PF08023; Antimicrobial_2; 1.
PE   1: Evidence at protein level;
KW   Amphibian defense peptide; Antibiotic; Antimicrobial;
KW   Direct protein sequencing; Disulfide bond; Secreted.
FT   PEPTIDE         1..37
FT                   /note="Esculentin-2JDb"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT                   /id="PRO_0000420134"
FT   DISULFID        31..37
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          12
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          13
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          14
FT                   /note="G or K"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          15
FT                   /note="K or G"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          22
FT                   /note="G or K"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          23
FT                   /note="K or G"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          26
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          28
FT                   /note="L or I"
FT                   /evidence="ECO:0000269|PubMed:22917879"
FT   UNSURE          33
FT                   /note="I or L"
FT                   /evidence="ECO:0000269|PubMed:22917879"
SQ   SEQUENCE   37 AA;  3822 MW;  BF7A58B931768D4A CRC64;
     GIFTLIKGAA KLIGKTVAKE AGKTGLELMA CKITNQC