ID   AGRB_STALU              Reviewed;         188 AA.
AC   Q54337; Q9S3T8;
DT   07-JUN-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 71.
DE   RecName: Full=Accessory gene regulator protein B {ECO:0000255|HAMAP-Rule:MF_00784};
DE            EC=3.4.-.- {ECO:0000255|HAMAP-Rule:MF_00784};
GN   Name=agrB {ECO:0000255|HAMAP-Rule:MF_00784};
OS   Staphylococcus lugdunensis.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=28035;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8359673; DOI=10.1111/j.1574-6968.1993.tb06370.x;
RA   Vandenesch F., Projan S.J., Kreiswirth B., Etienne J., Novick R.P.;
RT   "Agr-related sequences in Staphylococcus lugdunensis.";
RL   FEMS Microbiol. Lett. 111:115-122(1993).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=307 / RN8160;
RA   Benito Y.;
RT   "Full agr-sl sequence of Staphylococcus lugdunensis.";
RL   Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential for the production of a quorum sensing system
CC       signal molecule, the autoinducing peptide (AIP). This quorum sensing
CC       system is responsible for the regulation of the expression of virulence
CC       factor genes. Involved in the proteolytic processing of AgrD, the
CC       precursor of AIP. {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000255|HAMAP-Rule:MF_00784};
CC       Multi-pass membrane protein {ECO:0000255|HAMAP-Rule:MF_00784}.
CC   -!- SIMILARITY: Belongs to the AgrB family. {ECO:0000255|HAMAP-
CC       Rule:MF_00784}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAD51708.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; L13334; AAA71976.1; -; Unassigned_DNA.
DR   EMBL; AF173933; AAD51708.1; ALT_INIT; Genomic_DNA.
DR   AlphaFoldDB; Q54337; -.
DR   STRING; 698737.SLGD_00986; -.
DR   MEROPS; C75.001; -.
DR   eggNOG; COG4512; Bacteria.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008233; F:peptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   GO; GO:0009372; P:quorum sensing; IEA:UniProtKB-UniRule.
DR   HAMAP; MF_00784; AgrB; 1.
DR   InterPro; IPR006741; AgrB.
DR   Pfam; PF04647; AgrB; 1.
DR   SMART; SM00793; AgrB; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Hydrolase; Membrane; Protease; Quorum sensing;
KW   Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..188
FT                   /note="Accessory gene regulator protein B"
FT                   /id="PRO_0000168132"
FT   TRANSMEM        49..69
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        104..124
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00784"
SQ   SEQUENCE   188 AA;  21911 MW;  EBD393B0410C9714 CRC64;
     MKAIDKKIER FARYLQRQNN LDHIQFLKIR LGLQVALGNF FKTIVTYGVA LLFHTFLYTL
     ITHLTYFFVR RFAHGAHARS SLLCHIQNLV LFVALPWSIV HFQVSWTFMI FVAFIAFIII
     ICYAPSATKK QPILPHLRKK KKRNAILISI CFLVLMLFVS EPYMQLIALG MCIEAITLLP
     IFFSKEET