ESA8C_TRYEQ
ID ESA8C_TRYEQ Reviewed; 630 AA.
AC P26337;
DT 01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1992, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=Putative adenylate cyclase regulatory protein;
GN Name=ESAG8C;
OS Trypanosoma equiperdum.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX NCBI_TaxID=5694;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CL;
RX PubMed=2065652; DOI=10.1002/j.1460-2075.1991.tb07735.x;
RA Ross D.T., Raibaud A., Florent I.C., Sather S., Gross M.K., Storm D.R.,
RA Eisen H.;
RT "The trypanosome VSG expression site encodes adenylate cyclase and a
RT leucine-rich putative regulatory gene.";
RL EMBO J. 10:2047-2053(1991).
CC -!- FUNCTION: May interact with adenylate cyclase to regulate its activity.
CC -!- FUNCTION: May be involved in the postranscriptional regulation of genes
CC in VSG expression sites.
CC -!- DEVELOPMENTAL STAGE: Expressed only in the bloodstream form of the
CC parasite.
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DR EMBL; X59385; CAA42028.1; -; Genomic_DNA.
DR PIR; S16358; BWUT8Q.
DR AlphaFoldDB; P26337; -.
DR SMR; P26337; -.
DR GO; GO:0005929; C:cilium; IEA:UniProt.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006171; P:cAMP biosynthetic process; IEA:UniProtKB-KW.
DR Gene3D; 3.30.40.10; -; 1.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR006553; Leu-rich_rpt_Cys-con_subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SMART; SM00367; LRR_CC; 8.
DR SMART; SM00184; RING; 1.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 2: Evidence at transcript level;
KW cAMP biosynthesis; DNA-binding; Leucine-rich repeat; Metal-binding; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..630
FT /note="Putative adenylate cyclase regulatory protein"
FT /id="PRO_0000056367"
FT REPEAT 184..206
FT /note="LRR 1"
FT REPEAT 207..230
FT /note="LRR 2"
FT REPEAT 231..251
FT /note="LRR 3"
FT REPEAT 255..277
FT /note="LRR 4"
FT REPEAT 278..301
FT /note="LRR 5"
FT REPEAT 302..324
FT /note="LRR 6"
FT REPEAT 325..347
FT /note="LRR 7"
FT REPEAT 348..370
FT /note="LRR 8"
FT REPEAT 371..393
FT /note="LRR 9"
FT REPEAT 394..416
FT /note="LRR 10"
FT REPEAT 417..439
FT /note="LRR 11"
FT REPEAT 440..462
FT /note="LRR 12"
FT REPEAT 463..485
FT /note="LRR 13"
FT REPEAT 486..508
FT /note="LRR 14"
FT REPEAT 509..531
FT /note="LRR 15"
FT REPEAT 532..554
FT /note="LRR 16"
FT REPEAT 555..577
FT /note="LRR 17"
FT REPEAT 578..599
FT /note="LRR 18"
FT ZN_FING 10..46
FT /note="RING-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
SQ SEQUENCE 630 AA; 69990 MW; F882E49A6A6E6651 CRC64;
MTGRSTYGMC AVCREPWAEG ALELFPCRHV FCTVCVVERW RCPSCQRRIG GRRKANPHLL
REIAEVTMEL KRYRKGRSGI DVTQMARKLG GGGVTTSSEI FRRLEGSKNG RWKILNLSGC
GSELQDLTAL RDLEALEDLD LSECANLELR ELMVVLTLRN LRKLRMKRTM VNDMWCSSIG
LLKFLVHLEV DGSRGVTDIT GLCRLKTLEA LSLDSCINIT KGFDKICALP QLTSLSLCQT
NVTDKDLRCI HPDGKLKVLR YSSCHEITDL TAIGGMRSLE KLSLSGCWNV TKGLEELCKF
SNLRELDISG CLVLGSAVVL KNLINLKVLS VSNCKNFKDL NGLERLVNLD KLNLSGCHGV
SSLGFVANLS NLKELDISGC ESLVCFDGLQ DLNNLEVLYL RDVKSFTNVG AIKNLSKMRE
LDLSGCERIT SLSGLETLKG LEELSLEGCG EIMSFDPIWS LHHLRVLYVS ECGNLEDLSG
LEGITGLEEL YLHGCRKCTN FGPIWNLRNV CVVELSCCEN LEDLSGLQCL TGLEELYLIG
CEEITPIGVV GNLRNLKCLS TCWCANLKEL GGLDRLVNLE KLDLSGCCGL SSSVFMELMS
LPKLQWFYGF GSRVPDIVLE ELKRRGVHIF
