ID   ESAA_STAA8              Reviewed;        1009 AA.
AC   Q2G188;
DT   05-OCT-2016, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Type VII secretion system accessory factor EsaA {ECO:0000305};
GN   Name=esaA {ECO:0000303|PubMed:26785823};
GN   OrderedLocusNames=SAOUHSC_00258 {ECO:0000312|EMBL:ABD29432.1};
OS   Staphylococcus aureus (strain NCTC 8325 / PS 47).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=93061;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NCTC 8325 / PS 47;
RA   Gillaspy A.F., Worrell V., Orvis J., Roe B.A., Dyer D.W., Iandolo J.J.;
RT   "The Staphylococcus aureus NCTC 8325 genome.";
RL   (In) Fischetti V., Novick R., Ferretti J., Portnoy D., Rood J. (eds.);
RL   Gram positive pathogens, 2nd edition, pp.381-412, ASM Press, Washington
RL   D.C. (2006).
RN   [2]
RP   SUBUNIT, AND SUBCELLULAR LOCATION.
RC   STRAIN=RN6390;
RX   PubMed=26785823; DOI=10.1002/1873-3468.12065;
RA   Jaeger F., Zoltner M., Kneuper H., Hunter W.N., Palmer T.;
RT   "Membrane interactions and self-association of components of the Ess/Type
RT   VII secretion system of Staphylococcus aureus.";
RL   FEBS Lett. 590:349-357(2016).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Provides
CC       together with EssB and other components such as EssC and EssE a
CC       secretion platform across the cytoplasmic membrane in the host.
CC       {ECO:0000250|UniProtKB:A0A0H2XFP1}.
CC   -!- SUBUNIT: Homodimer (PubMed:26785823). Interacts with EssB (By
CC       similarity). {ECO:0000250|UniProtKB:A0A0H2XFP1,
CC       ECO:0000269|PubMed:26785823}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:26785823};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EsaA family. {ECO:0000305}.
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DR   EMBL; CP000253; ABD29432.1; -; Genomic_DNA.
DR   RefSeq; WP_000728949.1; NZ_LS483365.1.
DR   RefSeq; YP_498852.1; NC_007795.1.
DR   AlphaFoldDB; Q2G188; -.
DR   SMR; Q2G188; -.
DR   STRING; 1280.SAXN108_0263; -.
DR   EnsemblBacteria; ABD29432; ABD29432; SAOUHSC_00258.
DR   GeneID; 3919200; -.
DR   KEGG; sao:SAOUHSC_00258; -.
DR   PATRIC; fig|93061.5.peg.237; -.
DR   eggNOG; COG0842; Bacteria.
DR   eggNOG; COG1511; Bacteria.
DR   HOGENOM; CLU_015018_0_0_9; -.
DR   OMA; MYNFYKP; -.
DR   PRO; PR:Q2G188; -.
DR   Proteomes; UP000008816; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023838; T7SS_EsaA.
DR   TIGRFAMs; TIGR03929; T7_esaA_Nterm; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Transmembrane;
KW   Transmembrane helix; Virulence.
FT   CHAIN           1..1009
FT                   /note="Type VII secretion system accessory factor EsaA"
FT                   /id="PRO_0000437374"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        822..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        869..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        903..923
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        928..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        979..999
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          680..707
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..696
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1009 AA;  114826 MW;  2F9328179F8A1792 CRC64;
     MKKKNWIYAL IVTLIIIIAI VSMIFFVQTK YGDQSEKGSQ SVSNKNNKIH IAIVNEDQPT
     TYNGKKVELG QAFIKRLANE KNYKFETVTR NVAESGLKNG GYQVMIVIPE NFSKLAMQLD
     AKTPSKISLQ YKTAVGQKEE VAKNTEKVVS NVLNDFNKNL VEIYLTSIID NLHNAQKNVG
     AIMTREHGVN SKFSNYLLNP INDFPELFTD TLVNSISANK DITKWFQTYN KSLLSANSDT
     FRVNTDYNVS TLIEKQNSLF DEHNTAMDKM LQDYKSQKDS VELDNYINAL KQMDSQIDQQ
     SSMQDTGKEE YKQTVKENLD KLREIIQSQE SPFSKGMIED YRKQLTESLQ DELANNKDLQ
     DALNSIKMNN AQFAENLEKQ LHDDIVKEPD TDTTFIYNMS KQDFIAAGLN EDEANKYEAI
     VKEAKRYKNE YNLKKPLAEH INLTDYDNQV AQDTSSLIND GVKVQRTETI KSNDINQLTV
     ATDPHFNFEG DIKINGKKYD IKDQSVQLDT SNKEYKVEVN GVAKLKKDAE KDFLKDKTMH
     LQLLFGQANR QDEPNDKKAT SVVDVTLNHN LDGRLSKDAL SQQLSALSRF DAHYKMYTDT
     KGREDKPFDN KRLIDMMVDQ VINDMESFKD DKVAVLHQID SMEENSDKLI DDILNNKKNT
     TKNKEDISKL IDQLENVKKT FAEEPQEPKI DKGKNDEFNT MSSNLDKEIS RISEKSTQLL
     SDTQESKSIA DSVSGQLNQV DNNVNKLHAT GRALGVRAND LNRQMAKNDK DNELFAKEFK
     KVLQNSKDGD RQNQALKAFM SNPVQKKNLE NVLANNGNTD VISPTLFVLL MYLLSMITAY
     IFYSYERAKG QMNFIKDDYS SKNHLWNNVI TSGVIGTTGL VEGLIVGLIA MNKFHVLAGY
     RAKFILMVIL TMMVFVLINT YLLRQVKSIG MFLMIAALGL YFVAMNNLKA AGQGVTNKIS
     PLSYIDNMFF NYLNAEHPIG LVLVILTVLV IIGFVLNMFI KHFKKERLI