AGRD1_HUMAN
ID AGRD1_HUMAN Reviewed; 874 AA.
AC Q6QNK2; B2CKK9; B7ZLF7; Q2M1L3; Q6ZMQ1; Q7Z7M2; Q86SM4;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Adhesion G-protein coupled receptor D1 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G-protein coupled receptor 133;
DE AltName: Full=G-protein coupled receptor PGR25;
DE Flags: Precursor;
GN Name=ADGRD1; Synonyms=GPR133, PGR25;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RA Bonner T.I., Nagle J.W., Kauffman D.;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3).
RX PubMed=15203201; DOI=10.1016/j.ygeno.2003.12.004;
RA Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E.,
RA Lagerstroem M.C., Schioeth H.B.;
RT "The human and mouse repertoire of the adhesion family of G-protein-coupled
RT receptors.";
RL Genomics 84:23-33(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND ALTERNATIVE SPLICING.
RA Bonner T.I., Sloger M., Nagle J.W., Kauffman D.;
RT "Common splice variant of human GPR133 in brain.";
RL Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16541075; DOI=10.1038/nature04569;
RA Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y.,
RA Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C.,
RA Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C.,
RA Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R.,
RA Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E.,
RA Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y.,
RA Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G.,
RA Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H.,
RA Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S.,
RA Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M.,
RA Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H.,
RA Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q.,
RA Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V.,
RA Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E.,
RA Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K.,
RA Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D.,
RA Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R.,
RA David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E.,
RA D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N.,
RA Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N.,
RA Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R.,
RA Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S.,
RA LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H.,
RA Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P.,
RA Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G.,
RA Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E.,
RA Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S.,
RA Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O.,
RA Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J.,
RA Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A.,
RA Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M.,
RA Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I.,
RA Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A.,
RA Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y.,
RA Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A.,
RA Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F.,
RA Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L.,
RA Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G.,
RA Gibbs R.A.;
RT "The finished DNA sequence of human chromosome 12.";
RL Nature 440:346-351(2006).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 4).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 355-708.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [8]
RP FUNCTION, MUTAGENESIS OF HIS-543 AND LEU-808, SUBCELLULAR LOCATION, AND
RP DOMAIN.
RX PubMed=22025619; DOI=10.1074/jbc.c111.265934;
RA Bohnekamp J., Schoneberg T.;
RT "Cell adhesion receptor GPR133 couples to Gs protein.";
RL J. Biol. Chem. 286:41912-41916(2011).
RN [9]
RP FUNCTION.
RX PubMed=22575658; DOI=10.1016/j.febslet.2012.03.014;
RA Gupte J., Swaminath G., Danao J., Tian H., Li Y., Wu X.;
RT "Signaling property study of adhesion G-protein-coupled receptors.";
RL FEBS Lett. 586:1214-1219(2012).
RN [10]
RP STACHEL MOTIF, MUTAGENESIS OF THR-545; LEU-550; MET-551 AND VAL-554, AND
RP SUBCELLULAR LOCATION.
RX PubMed=25533341; DOI=10.1016/j.celrep.2014.11.036;
RA Liebscher I., Schoen J., Petersen S.C., Fischer L., Auerbach N.,
RA Demberg L.M., Mogha A., Coester M., Simon K.U., Rothemund S., Monk K.R.,
RA Schoeneberg T.;
RT "A tethered agonist within the ectodomain activates the adhesion G protein-
RT coupled receptors GPR126 and GPR133.";
RL Cell Rep. 9:2018-2026(2014).
RN [11]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
RN [12]
RP CHARACTERIZATION OF VARIANTS CYS-18; HIS-18; ASN-32; LYS-78; MET-82;
RP CYS-85; ASP-89; MET-110; PHE-138; SER-140; ASP-141; LEU-145; TRP-150;
RP SER-174; LYS-178; ILE-184; ARG-195; CYS-199; HIS-199; ASP-203; MET-209;
RP ASN-226; TRP-233; THR-241; THR-242; ILE-245; ALA-257; GLN-259; TYR-265;
RP ASN-268; ALA-270; MET-270; ALA-293; ARG-294; SER-308; PHE-318; ASN-349;
RP SER-364; MET-369; SER-383; MET-393; GLN-397; CYS-399; PRO-405; PRO-410;
RP SER-411; LYS-413; VAL-419; SER-425; THR-441; ASP-448; ASN-453; TYR-454;
RP THR-458; ALA-464; SER-476; LEU-478; MET-484; ILE-485; GLY-498; SER-499;
RP MET-508; LEU-523; SER-524; ALA-538; ILE-538; CYS-540; HIS-540; CYS-560;
RP HIS-560; LEU-567; VAL-569; THR-589; MET-594; HIS-601; HIS-608; CYS-624;
RP LYS-626; LEU-667; HIS-673; THR-695; ARG-699; VAL-720; THR-743; ARG-749;
RP GLU-751; GLU-761; MET-777; VAL-779; MET-793; LYS-795; THR-816; MET-827;
RP THR-831; THR-836; VAL-836; THR-851; HIS-868; ILE-869; ASN-870 AND MET-874.
RX PubMed=27516204; DOI=10.1186/s12864-016-2937-2;
RA Fischer L., Wilde C., Schoeneberg T., Liebscher I.;
RT "Functional relevance of naturally occurring mutations in adhesion G
RT protein-coupled receptor ADGRD1 (GPR133).";
RL BMC Genomics 17:609-609(2016).
RN [13]
RP INDUCTION, AND TISSUE SPECIFICITY.
RX PubMed=27775701; DOI=10.1038/oncsis.2016.63;
RA Bayin N.S., Frenster J.D., Kane J.R., Rubenstein J., Modrek A.S.,
RA Baitalmal R., Dolgalev I., Rudzenski K., Scarabottolo L., Crespi D.,
RA Redaelli L., Snuderl M., Golfinos J.G., Doyle W., Pacione D., Parker E.C.,
RA Chi A.S., Heguy A., MacNeil D.J., Shohdy N., Zagzag D., Placantonakis D.G.;
RT "GPR133 (ADGRD1), an adhesion G-protein-coupled receptor, is necessary for
RT glioblastoma growth.";
RL Oncogenesis 5:E263-E263(2016).
CC -!- FUNCTION: Orphan receptor. Signals via G(s)-alpha family of G-proteins
CC (PubMed:22025619, PubMed:22575658). Has protumorigenic function
CC especially in glioblastoma (PubMed:27775701).
CC {ECO:0000269|PubMed:22025619, ECO:0000269|PubMed:22575658,
CC ECO:0000269|PubMed:27775701}.
CC -!- INTERACTION:
CC Q6QNK2; O60831: PRAF2; NbExp=3; IntAct=EBI-18053335, EBI-2506064;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:22025619,
CC ECO:0000269|PubMed:25533341}; Multi-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q6QNK2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6QNK2-2; Sequence=VSP_012788, VSP_012789;
CC Name=3;
CC IsoId=Q6QNK2-3; Sequence=VSP_012787, VSP_012790;
CC Name=4;
CC IsoId=Q6QNK2-4; Sequence=VSP_053678;
CC -!- TISSUE SPECIFICITY: Up-regulated in CD133(+) cell population of
CC glioblastoma. {ECO:0000269|PubMed:27775701}.
CC -!- INDUCTION: Up-regulated by hypoxia in hypoxia-inducible factor 1-alpha
CC (HIF1A)-dependent manner. {ECO:0000269|PubMed:27775701}.
CC -!- DOMAIN: A short peptide sequence (termed the Stachel sequence) in the
CC C-terminal part of the extracellular domain (ECD) functions as a
CC tethered agonist. Upon structural changes within the ECD, e.g. due to
CC extracellular ligand binding or mechanical movements, this
CC intramolecular agonist is exposed to the 7 transmembrane region,
CC triggering G-protein activation. {ECO:0000269|PubMed:25533341}.
CC -!- DOMAIN: The N-terminal domain and autocatalytic activity of ADGRD1 at
CC the GPCR proteolysis site (GPS) are not required for G-protein coupling
CC activity. {ECO:0000269|PubMed:22025619}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AY532280; AAS37682.1; -; mRNA.
DR EMBL; AY278561; AAP35063.1; -; mRNA.
DR EMBL; EU523118; ACB20802.1; -; mRNA.
DR EMBL; AK131538; BAD18674.1; -; mRNA.
DR EMBL; AC073862; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC078925; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC126564; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC112307; AAI12308.1; -; mRNA.
DR EMBL; BC112309; AAI12310.1; -; mRNA.
DR EMBL; BC143775; AAI43776.1; -; mRNA.
DR EMBL; AY255587; AAO85099.1; -; mRNA.
DR CCDS; CCDS81753.1; -. [Q6QNK2-4]
DR CCDS; CCDS9272.1; -. [Q6QNK2-1]
DR PIR; T47186; T47186.
DR RefSeq; NP_001317426.1; NM_001330497.1. [Q6QNK2-4]
DR RefSeq; NP_942122.2; NM_198827.4. [Q6QNK2-1]
DR AlphaFoldDB; Q6QNK2; -.
DR BioGRID; 129544; 4.
DR IntAct; Q6QNK2; 1.
DR STRING; 9606.ENSP00000261654; -.
DR ChEMBL; CHEMBL4523877; -.
DR DrugBank; DB12637; Onapristone.
DR MEROPS; P02.021; -.
DR GlyConnect; 1913; 7 N-Linked glycans (4 sites).
DR GlyGen; Q6QNK2; 11 sites, 7 N-linked glycans (4 sites), 1 O-linked glycan (1 site).
DR iPTMnet; Q6QNK2; -.
DR PhosphoSitePlus; Q6QNK2; -.
DR BioMuta; ADGRD1; -.
DR DMDM; 59797935; -.
DR MassIVE; Q6QNK2; -.
DR PaxDb; Q6QNK2; -.
DR PeptideAtlas; Q6QNK2; -.
DR PRIDE; Q6QNK2; -.
DR ProteomicsDB; 67303; -. [Q6QNK2-1]
DR ProteomicsDB; 7223; -.
DR Antibodypedia; 19419; 181 antibodies from 27 providers.
DR DNASU; 283383; -.
DR Ensembl; ENST00000261654.10; ENSP00000261654.5; ENSG00000111452.13. [Q6QNK2-1]
DR Ensembl; ENST00000535015.5; ENSP00000444425.1; ENSG00000111452.13. [Q6QNK2-4]
DR Ensembl; ENST00000543617.2; ENSP00000438021.1; ENSG00000111452.13. [Q6QNK2-3]
DR GeneID; 283383; -.
DR KEGG; hsa:283383; -.
DR MANE-Select; ENST00000261654.10; ENSP00000261654.5; NM_198827.5; NP_942122.2.
DR UCSC; uc001uit.5; human. [Q6QNK2-1]
DR CTD; 283383; -.
DR DisGeNET; 283383; -.
DR GeneCards; ADGRD1; -.
DR HGNC; HGNC:19893; ADGRD1.
DR HPA; ENSG00000111452; Tissue enhanced (heart).
DR MIM; 613639; gene.
DR neXtProt; NX_Q6QNK2; -.
DR OpenTargets; ENSG00000111452; -.
DR PharmGKB; PA134923933; -.
DR VEuPathDB; HostDB:ENSG00000111452; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000159783; -.
DR HOGENOM; CLU_008509_0_0_1; -.
DR InParanoid; Q6QNK2; -.
DR PhylomeDB; Q6QNK2; -.
DR TreeFam; TF351999; -.
DR PathwayCommons; Q6QNK2; -.
DR SignaLink; Q6QNK2; -.
DR BioGRID-ORCS; 283383; 11 hits in 1074 CRISPR screens.
DR ChiTaRS; ADGRD1; human.
DR GenomeRNAi; 283383; -.
DR Pharos; Q6QNK2; Tbio.
DR PRO; PR:Q6QNK2; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6QNK2; protein.
DR Bgee; ENSG00000111452; Expressed in cardiac muscle of right atrium and 129 other tissues.
DR ExpressionAtlas; Q6QNK2; baseline and differential.
DR Genevisible; Q6QNK2; HS.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005886; C:plasma membrane; IDA:UniProtKB.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IDA:UniProtKB.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IDA:UniProtKB.
DR Gene3D; 2.60.220.50; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR SMART; SM00303; GPS; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..874
FT /note="Adhesion G-protein coupled receptor D1"
FT /id="PRO_0000012905"
FT TOPO_DOM 26..570
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 571..591
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 592..602
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 603..623
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 624..633
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 634..654
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 655..674
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 675..695
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 696..711
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 712..732
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 733..760
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 761..781
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 782..784
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 785..805
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 806..874
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 79..276
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT DOMAIN 507..556
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT REGION 854..874
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 546..554
FT /note="Stachel"
FT /evidence="ECO:0000305|PubMed:25533341"
FT CARBOHYD 90
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 302
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 319
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 394
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 501
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 533
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..481
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15203201"
FT /id="VSP_012787"
FT VAR_SEQ 1..314
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_012788"
FT VAR_SEQ 62
FT /note="G -> GASRTHKLTVLPSRNATFVYSNDSAYSNLSATV (in isoform
FT 4)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_053678"
FT VAR_SEQ 315..341
FT /note="QTALNLTKTFLKAVGEILLLPGWIALS -> MEKGTELLVSPSQSGPGGDQP
FT LLVKHR (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_012789"
FT VAR_SEQ 482..491
FT /note="LITVHLKHRL -> MHRVCFLSFQ (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15203201"
FT /id="VSP_012790"
FT VARIANT 18
FT /note="Y -> C (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs149181066)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077698"
FT VARIANT 18
FT /note="Y -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146611221)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077699"
FT VARIANT 32
FT /note="D -> N (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs376178471)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077700"
FT VARIANT 78
FT /note="E -> K (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs267603378)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077701"
FT VARIANT 82
FT /note="T -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs143395855)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077702"
FT VARIANT 85
FT /note="Y -> C (does not affect subcellular location;
FT decreases G-protein coupled receptor activity;
FT dbSNP:rs199848650)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077703"
FT VARIANT 89
FT /note="Y -> D (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201546462)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077704"
FT VARIANT 110
FT /note="F -> L (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs148928637)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077705"
FT VARIANT 138
FT /note="S -> F (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs199526762)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077706"
FT VARIANT 140
FT /note="G -> S (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs374985420)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077707"
FT VARIANT 141
FT /note="G -> D (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs142759046)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077708"
FT VARIANT 145
FT /note="V -> L (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146945782)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077709"
FT VARIANT 150
FT /note="R -> W (does not affect subcellular location;
FT decreases G-protein coupled receptor activity;
FT dbSNP:rs144030317)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077710"
FT VARIANT 174
FT /note="W -> S (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs141606054)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077711"
FT VARIANT 178
FT /note="E -> K (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs148148477)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077712"
FT VARIANT 184
FT /note="V -> I (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs61732860)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077713"
FT VARIANT 195
FT /note="G -> R (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs267603379)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077714"
FT VARIANT 199
FT /note="R -> C (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146310036)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077715"
FT VARIANT 199
FT /note="R -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs375084180)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077716"
FT VARIANT 203
FT /note="E -> D (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201045213)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077717"
FT VARIANT 209
FT /note="V -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs139478688)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077718"
FT VARIANT 226
FT /note="D -> N (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs377562590)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077719"
FT VARIANT 233
FT /note="R -> W (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs370807516)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077720"
FT VARIANT 241
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs368468703)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077721"
FT VARIANT 242
FT /note="M -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201057341)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077722"
FT VARIANT 245
FT /note="T -> I (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201053759)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077723"
FT VARIANT 257
FT /note="T -> A (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146563785)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077724"
FT VARIANT 259
FT /note="P -> Q (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs75096240)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077725"
FT VARIANT 265
FT /note="S -> Y (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs137909892)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077726"
FT VARIANT 268
FT /note="S -> N (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs149012578)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077727"
FT VARIANT 270
FT /note="V -> A (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs147773154)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077728"
FT VARIANT 270
FT /note="V -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs147105264)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077729"
FT VARIANT 293
FT /note="P -> A (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146929634)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077730"
FT VARIANT 294
FT /note="G -> R (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs148017957)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077731"
FT VARIANT 308
FT /note="P -> S (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201661954)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077732"
FT VARIANT 318
FT /note="L -> F (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs200641036)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077733"
FT VARIANT 349
FT /note="S -> N (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs370854685)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077734"
FT VARIANT 364
FT /note="N -> S (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146050435)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077735"
FT VARIANT 369
FT /note="T -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs142314859)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077736"
FT VARIANT 383
FT /note="F -> S (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs200232576)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077737"
FT VARIANT 393
FT /note="V -> M (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs374606811)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077738"
FT VARIANT 397
FT /note="H -> Q (does not affect subcellular location;
FT dbSNP:rs201985264)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077739"
FT VARIANT 399
FT /note="R -> C (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs150882180)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077740"
FT VARIANT 404
FT /note="G -> A (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs371536090)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077741"
FT VARIANT 405
FT /note="Q -> P (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs145663007)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077742"
FT VARIANT 410
FT /note="I -> V (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs376489706)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077743"
FT VARIANT 411
FT /note="P -> S (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs147757048)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077744"
FT VARIANT 413
FT /note="E -> K (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs142628291)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077745"
FT VARIANT 419
FT /note="A -> V (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs370959644)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077746"
FT VARIANT 425
FT /note="G -> S (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs374575404)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077747"
FT VARIANT 441
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs375271891)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077748"
FT VARIANT 448
FT /note="A -> D (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs200173874)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077749"
FT VARIANT 450
FT /note="H -> R (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs200060202)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077750"
FT VARIANT 453
FT /note="D -> N (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs149065791)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077751"
FT VARIANT 454
FT /note="C -> Y (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs143062748)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077752"
FT VARIANT 458
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs140426880)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077753"
FT VARIANT 464
FT /note="S -> A (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs78638447)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077754"
FT VARIANT 476
FT /note="N -> S (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs138163855)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077755"
FT VARIANT 478
FT /note="S -> L (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs372643228)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077756"
FT VARIANT 484
FT /note="T -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs149266247)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077757"
FT VARIANT 485
FT /note="V -> I (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs369012277)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077758"
FT VARIANT 498
FT /note="E -> G (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs200576124)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077759"
FT VARIANT 499
FT /note="A -> S (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs150620459)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077760"
FT VARIANT 508
FT /note="V -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs11833801)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_049461"
FT VARIANT 523
FT /note="S -> L (does not change G-protein coupled receptor
FT activity; dbSNP:rs11061318)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_049462"
FT VARIANT 524
FT /note="N -> K (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs370443698)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077761"
FT VARIANT 538
FT /note="V -> A (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201849687)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077762"
FT VARIANT 538
FT /note="V -> I (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs200971352)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077763"
FT VARIANT 540
FT /note="R -> C (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs147294464)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077764"
FT VARIANT 540
FT /note="R -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs145630930)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077765"
FT VARIANT 560
FT /note="R -> C (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs371989819)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077766"
FT VARIANT 560
FT /note="R -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs375179921)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077767"
FT VARIANT 567
FT /note="S -> L (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs192515185)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077768"
FT VARIANT 569
FT /note="I -> V (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs139017446)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077769"
FT VARIANT 589
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201161291)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077770"
FT VARIANT 594
FT /note="V -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs189007948)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077771"
FT VARIANT 601
FT /note="R -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs201524753)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077772"
FT VARIANT 608
FT /note="L -> M (does not affect subcellular location;
FT decreases G-protein coupled receptor activity;
FT dbSNP:rs200052797)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077773"
FT VARIANT 624
FT /note="R -> C (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs117457351)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077774"
FT VARIANT 626
FT /note="E -> K (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs199778477)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077775"
FT VARIANT 630
FT /note="T -> I (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs145482553)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077776"
FT VARIANT 667
FT /note="S -> L (does not affect subcellular location;
FT decreases G-protein coupled receptor activity;
FT dbSNP:rs377401276)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077777"
FT VARIANT 673
FT /note="R -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs141128784)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077778"
FT VARIANT 695
FT /note="M -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs143163307)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077779"
FT VARIANT 699
FT /note="G -> R (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs149859410)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077780"
FT VARIANT 720
FT /note="A -> V (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs141439159)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077781"
FT VARIANT 743
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs143902981)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077782"
FT VARIANT 749
FT /note="H -> R (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs372207677)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077783"
FT VARIANT 751
FT /note="D -> E (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs147763331)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077784"
FT VARIANT 761
FT /note="A -> E (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs369201469)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077785"
FT VARIANT 764
FT /note="V -> M (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs149434203)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077786"
FT VARIANT 777
FT /note="V -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs144814859)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077787"
FT VARIANT 779
FT /note="A -> V (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs61746588)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077788"
FT VARIANT 793
FT /note="T -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs375488636)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077789"
FT VARIANT 795
FT /note="N -> K (decreases cell surface location; abolishes
FT G-protein coupled receptor activity; dbSNP:rs369853823)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077790"
FT VARIANT 816
FT /note="A -> T (reduces cell membrane location; decreases G-
FT protein coupled receptor activity; dbSNP:rs368828722)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077791"
FT VARIANT 827
FT /note="T -> M (does not affect subcellular location;
FT increases G-protein coupled receptor activity;
FT dbSNP:rs371135988)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077792"
FT VARIANT 831
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs146661482)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077793"
FT VARIANT 836
FT /note="A -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs144023497)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077794"
FT VARIANT 836
FT /note="A -> V (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs367789023)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077795"
FT VARIANT 851
FT /note="M -> T (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs78058857)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077796"
FT VARIANT 868
FT /note="R -> H (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs61740366)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077797"
FT VARIANT 869
FT /note="V -> I (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs377434309)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077798"
FT VARIANT 870
FT /note="D -> N (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs143670024)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077799"
FT VARIANT 874
FT /note="V -> M (does not affect subcellular location; does
FT not change G-protein coupled receptor activity;
FT dbSNP:rs148442158)"
FT /evidence="ECO:0000269|PubMed:27516204"
FT /id="VAR_077800"
FT MUTAGEN 543
FT /note="H->R: Does not affect membrane trafficking and basal
FT activity."
FT /evidence="ECO:0000269|PubMed:22025619"
FT MUTAGEN 545
FT /note="T->A: No effect on G-protein coupled receptor
FT activity; does not affect subcellular location."
FT /evidence="ECO:0000269|PubMed:25533341"
FT MUTAGEN 550
FT /note="L->A: Abolishes G-protein coupled receptor activity;
FT does not affect subcellular location."
FT /evidence="ECO:0000269|PubMed:25533341"
FT MUTAGEN 551
FT /note="M->A: Abolishes G-protein coupled receptor activity;
FT does not affect subcellular location."
FT /evidence="ECO:0000269|PubMed:25533341"
FT MUTAGEN 554
FT /note="V->A: Abolishes G-protein coupled receptor activity;
FT does not affect subcellular location."
FT /evidence="ECO:0000269|PubMed:25533341"
FT MUTAGEN 808
FT /note="L->T: Does not affect membrane trafficking.
FT Abolishes receptor activity."
FT /evidence="ECO:0000269|PubMed:22025619"
FT CONFLICT 703
FT /note="N -> S (in Ref. 2; AAP35063)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 874 AA; 96530 MW; 8FC7C63D50F65E1B CRC64;
MEKLLRLCCW YSWLLLFYYN FQVRGVYSRS QDHPGFQVLA SASHYWPLEN VDGIHELQDT
TGDIVEGKVN KGIYLKEEKG VTLLYYGRYN SSCISKPEQC GPEGVTFSFF WKTQGEQSRP
IPSAYGGQVI SNGFKVCSSG GRGSVELYTR DNSMTWEASF SPPGPYWTHV LFTWKSKEGL
KVYVNGTLST SDPSGKVSRD YGESNVNLVI GSEQDQAKCY ENGAFDEFII WERALTPDEI
AMYFTAAIGK HALLSSTLPS LFMTSTASPV MPTDAYHPII TNLTEERKTF QSPGVILSYL
QNVSLSLPSK SLSEQTALNL TKTFLKAVGE ILLLPGWIAL SEDSAVVLSL IDTIDTVMGH
VSSNLHGSTP QVTVEGSSAM AEFSVAKILP KTVNSSHYRF PAHGQSFIQI PHEAFHRHAW
STVVGLLYHS MHYYLNNIWP AHTKIAEAMH HQDCLLFATS HLISLEVSPP PTLSQNLSGS
PLITVHLKHR LTRKQHSEAT NSSNRVFVYC AFLDFSSGEG VWSNHGCALT RGNLTYSVCR
CTHLTNFAIL MQVVPLELAR GHQVALSSIS YVGCSLSVLC LVATLVTFAV LSSVSTIRNQ
RYHIHANLSF AVLVAQVLLL ISFRLEPGTT PCQVMAVLLH YFFLSAFAWM LVEGLHLYSM
VIKVFGSEDS KHRYYYGMGW GFPLLICIIS LSFAMDSYGT SNNCWLSLAS GAIWAFVAPA
LFVIVVNIGI LIAVTRVISQ ISADNYKIHG DPSAFKLTAK AVAVLLPILG TSWVFGVLAV
NGCAVVFQYM FATLNSLQGL FIFLFHCLLN SEVRAAFKHK TKVWSLTSSS ARTSNAKPFH
SDLMNGTRPG MASTKLSPWD KSSHSAHRVD LSAV
