ID   ESAA_STAAN              Reviewed;        1009 AA.
AC   Q7A7S3;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 85.
DE   RecName: Full=Type VII secretion system accessory factor EsaA {ECO:0000250|UniProtKB:P0C049};
GN   Name=esaA {ECO:0000250|UniProtKB:P0C049}; OrderedLocusNames=SA0272;
OS   Staphylococcus aureus (strain N315).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158879;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=N315;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Provides
CC       together with EssB and other components such as EssC and EssE a
CC       secretion platform across the cytoplasmic membrane in the host.
CC       {ECO:0000250|UniProtKB:A0A0H2XFP1}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with EssB (By
CC       similarity). {ECO:0000250|UniProtKB:A0A0H2XFP1,
CC       ECO:0000250|UniProtKB:Q2G188}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2G188};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EsaA family. {ECO:0000305}.
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DR   EMBL; BA000018; BAB41496.1; -; Genomic_DNA.
DR   PIR; E89792; E89792.
DR   RefSeq; WP_000728958.1; NC_002745.2.
DR   AlphaFoldDB; Q7A7S3; -.
DR   SMR; Q7A7S3; -.
DR   EnsemblBacteria; BAB41496; BAB41496; BAB41496.
DR   KEGG; sau:SA0272; -.
DR   HOGENOM; CLU_015018_0_0_9; -.
DR   OMA; MYNFYKP; -.
DR   Proteomes; UP000000751; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023838; T7SS_EsaA.
DR   TIGRFAMs; TIGR03929; T7_esaA_Nterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..1009
FT                   /note="Type VII secretion system accessory factor EsaA"
FT                   /id="PRO_0000087038"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        822..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        869..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        903..923
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        928..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        979..999
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1009 AA;  114782 MW;  16AD06D170CA31FE CRC64;
     MKKKNWIYAL IVTLIIIIAI VSMIFFVQTK YGDQSEKGSQ SVSNKNNKIH IAIVNEDQPT
     TYNGKKVELG QAFIKRLANE KNYKFETVTR NVAESGLKNG GYQVMIVIPE NFSKLAMQLD
     AKTPSKISLQ YKTAVGQKEE VAKNTEKVVS NVLNDFNKNL VEIYLTSIID NLHNAQKNVG
     AIMTREHGVN SKFSNYLLNP INDFPELFTD TLVNSISANK DITKWFQTYN KSLLSANSDT
     FRVNTDYNVS TLIEKQNSLF DEHNTAMDKM LQDYKSQKDS VELDNYINAL KQMDSQIDQQ
     SSMQDTGKEE YKQTVKENLD KLREIIQSQE SPFSKGMIED YRKQLTESLQ DELANNKDLQ
     DALNSIKMNN AQFAENLEKQ LHDDIVKEPD TDTTFIYNMS KQDFIAAGLN EGEANKYEAI
     VKEAKRYKNE YNLKKPLAEH INLTDYDNQV AQDTSSLIND GVKVQRTETI KSNDINQLTV
     ATDPHFNFEG DIKINGKKYD IKDQSVQLDT SNKEYKVEVN GVAKLKKDAE KDFLKDKTMH
     LQLLFGQANR QDEPNDKKAT SVVDVTLNHN LDGRLSKDAL SQQLSALSRF DAHYKMYTDT
     KGREDKPFDN KRLIDMMVDQ VINDMESFKD DKVAVLHQID SMEENSDKLI DDILNNKKNT
     TKNKEDISKL IDQLENVKKT FAEEPQEPKI DKGKNDEFNT MSSNLDKEIS RISEKSTQLL
     SDTQESKTIA DSVSGQLNQL DNNVNKLHAT GRALGVRAND LNRQMAKNDK DNELFAKEFK
     KVLQNSKDGD RQNQALKAFM SNPVQKKNLE NVLANNGNTE VISPTLFVLL MYLLSMITAY
     IFYSYERAKG QMNFIKDDYS SKNHLWNNVI TSGVIGTTGL VEGLIVGLIA MNKFHVLAGY
     RAKFILMVIL TMMVFVLINT YLLRQVKSIG MFLMIAALGL YFVAMNNLKA AGQGVTNKIS
     PLSYIDNMFF NYLNAEHPIG LALVILTVLV IIGFVLNMFI KHFKKERLI