ID   ESAA_STAAS              Reviewed;        1009 AA.
AC   Q6GCI9;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Type VII secretion system accessory factor EsaA {ECO:0000250|UniProtKB:P0C049};
GN   Name=esaA {ECO:0000250|UniProtKB:P0C049}; OrderedLocusNames=SAS0259;
OS   Staphylococcus aureus (strain MSSA476).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=282459;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MSSA476;
RX   PubMed=15213324; DOI=10.1073/pnas.0402521101;
RA   Holden M.T.G., Feil E.J., Lindsay J.A., Peacock S.J., Day N.P.J.,
RA   Enright M.C., Foster T.J., Moore C.E., Hurst L., Atkin R., Barron A.,
RA   Bason N., Bentley S.D., Chillingworth C., Chillingworth T., Churcher C.,
RA   Clark L., Corton C., Cronin A., Doggett J., Dowd L., Feltwell T., Hance Z.,
RA   Harris B., Hauser H., Holroyd S., Jagels K., James K.D., Lennard N.,
RA   Line A., Mayes R., Moule S., Mungall K., Ormond D., Quail M.A.,
RA   Rabbinowitsch E., Rutherford K.M., Sanders M., Sharp S., Simmonds M.,
RA   Stevens K., Whitehead S., Barrell B.G., Spratt B.G., Parkhill J.;
RT   "Complete genomes of two clinical Staphylococcus aureus strains: evidence
RT   for the rapid evolution of virulence and drug resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:9786-9791(2004).
CC   -!- FUNCTION: Component of the type VII secretion system (Ess). Provides
CC       together with EssB and other components such as EssC and EssE a
CC       secretion platform across the cytoplasmic membrane in the host.
CC       {ECO:0000250|UniProtKB:A0A0H2XFP1}.
CC   -!- SUBUNIT: Homodimer (By similarity). Interacts with EssB (By
CC       similarity). {ECO:0000250|UniProtKB:A0A0H2XFP1,
CC       ECO:0000250|UniProtKB:Q2G188}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q2G188};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the EsaA family. {ECO:0000305}.
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DR   EMBL; BX571857; CAG42030.1; -; Genomic_DNA.
DR   RefSeq; WP_000728972.1; NC_002953.3.
DR   AlphaFoldDB; Q6GCI9; -.
DR   SMR; Q6GCI9; -.
DR   KEGG; sas:SAS0259; -.
DR   HOGENOM; CLU_015018_0_0_9; -.
DR   OMA; MYNFYKP; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR023838; T7SS_EsaA.
DR   TIGRFAMs; TIGR03929; T7_esaA_Nterm; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix; Virulence.
FT   CHAIN           1..1009
FT                   /note="Type VII secretion system accessory factor EsaA"
FT                   /id="PRO_0000087040"
FT   TRANSMEM        7..27
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        822..842
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        869..889
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        903..923
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        928..948
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        979..999
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   1009 AA;  114884 MW;  BD4DB68F7E5AC2BE CRC64;
     MKKKNWIYAL IVTLIIIIAI VSMIFFVQTK YGDQSEKGSR SVSNKNNKIH IAIVNEDQPT
     TYNGKKVELG QAFIKRLANE KNYKFETVTR NVAESGLKNG GYQVMIVIPE NFSKLAMQLD
     AKTPSKISLQ YKTAVGQKEE VAKNTEKVVS NVLNDFNKNL VEIYLTSIID NLHNAQKNVG
     AIMTREHGVN SKFSNYLLNP INDFPELFTD TLVNSISANK DITKWFQTYN KSLLSANSDT
     FRVNTDYNVS TLIEKQNSLF DEHNTAMDKM LQDYKSQKDS VELDNYINAL KQMDSQIDQQ
     SSMQDTGKEE YKQTVKENLD KLREIIQSQE SPFSKGMIED YRKQLTESLQ DELANNKDLQ
     DALNSIKMNN AQFAENLEKQ LHDDIVKEPD TDTTFIYNMS KQDFIAAGLN EDEANKYEAI
     VKEAKRYKNE YNLKKPLAEH INLTDYDNQV AQDTSSLIND GVKVQRTETI KSNDINQLTV
     ATDPHFNFEG DIKINGKKYD IKDQSVQLDT SNKEYKVEVN GVAKLKKDAE KDFLKDKTMH
     LQLLFGQANR QDEPNDKKTT SVVDVTLNHN LDGRLSKDAL SQQLSALSRF DAHYKMYTDT
     KGREDKPFDN KRLIDMMVDQ VINDMESFKD DKVAVLHQID SMEENSDKLI DDILNNKKNT
     TKNKEDISKL IDQLENVKKT FAEEPQEPKI DKGKNDEFNT MSSNLDKEIS RISEKSTQLL
     SDTQESKTIA DSVSGQLNQL DNNVNKLHAT GRALGVRAND LNRQMAKNDK DNELFAKEFK
     KVLQNSKDGD RQNQALKAFM SNPVQKKNLE NVLANNGNTD VISPTLFVLL MYLLSMITAY
     IFYSYERAKG QMNFIKDDYS SKNHLWNNVI TSGVIGTTGL VEGLIVGLIA MNKFHVLAGY
     RAKFILMVIL TMMVFVLINT YLLRQVKSIG MFLMIAALGL YFVAMNNLKA AGQGVTNKIS
     PLSYIDNMFF NYLNAEHPIG LALVILTVLV IIGFVLNMFI KHFKKERLI