ID   ESAB_STAAE              Reviewed;          80 AA.
AC   P0C050;
DT   05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Type VII secretion system accessory factor EsaB {ECO:0000305};
GN   Name=esaB {ECO:0000303|PubMed:15657139}; OrderedLocusNames=NWMN_0221.1;
OS   Staphylococcus aureus (strain Newman).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=426430;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Newman;
RX   PubMed=17951380; DOI=10.1128/jb.01000-07;
RA   Baba T., Bae T., Schneewind O., Takeuchi F., Hiramatsu K.;
RT   "Genome sequence of Staphylococcus aureus strain Newman and comparative
RT   analysis of staphylococcal genomes: polymorphism and evolution of two major
RT   pathogenicity islands.";
RL   J. Bacteriol. 190:300-310(2008).
RN   [2]
RP   FUNCTION IN VIRULENCE.
RC   STRAIN=Newman;
RX   PubMed=15657139; DOI=10.1073/pnas.0405620102;
RA   Burts M.L., Williams W.A., DeBord K., Missiakas D.M.;
RT   "EsxA and EsxB are secreted by an ESAT-6-like system that is required for
RT   the pathogenesis of Staphylococcus aureus infections.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:1169-1174(2005).
RN   [3]
RP   FUNCTION, SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=Newman;
RX   PubMed=18554323; DOI=10.1111/j.1365-2958.2008.06324.x;
RA   Burts M.L., DeDent A.C., Missiakas D.M.;
RT   "EsaC substrate for the ESAT-6 secretion pathway and its role in persistent
RT   infections of Staphylococcus aureus.";
RL   Mol. Microbiol. 69:736-746(2008).
CC   -!- FUNCTION: Seems to regulate secreted factors that contribute to the
CC       establishment of persistent infections in the host. Negative regulator
CC       of EsxC. Not necessary for the production and secretion of EsxA or
CC       EsxB. {ECO:0000269|PubMed:15657139, ECO:0000269|PubMed:18554323}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:18554323}.
CC   -!- DISRUPTION PHENOTYPE: Deletion mutants display only a small defect in
CC       acute infection, but remarkably are unable to promote persistent
CC       abscesses during animal infection. {ECO:0000269|PubMed:18554323}.
CC   -!- SIMILARITY: Belongs to the EsaB family. {ECO:0000305}.
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DR   EMBL; AP009351; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; WP_001071606.1; NZ_CP023390.1.
DR   AlphaFoldDB; P0C050; -.
DR   SMR; P0C050; -.
DR   GeneID; 66838588; -.
DR   OMA; MAKDTHM; -.
DR   Proteomes; UP000006386; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR014921; EsaB.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   InterPro; IPR024962; YukD-like.
DR   Pfam; PF08817; YukD; 1.
DR   PIRSF; PIRSF037793; DUF_ubiquitin-like_YukD; 1.
DR   SUPFAM; SSF54236; SSF54236; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Virulence.
FT   CHAIN           1..80
FT                   /note="Type VII secretion system accessory factor EsaB"
FT                   /id="PRO_0000087048"
SQ   SEQUENCE   80 AA;  9121 MW;  28C666A3B6F99FA6 CRC64;
     MNQHVKVTFD FTNYNYGTYD LAVPAYLPIK NLIALVLDSL DISIFDVNTQ IKVMTKGQLL
     VENDRLIDYQ IADGDILKLL