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AGRD1_MOUSE
ID   AGRD1_MOUSE             Reviewed;         903 AA.
AC   Q80T32; B2RXC3; Q8BW80;
DT   02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   02-OCT-2007, sequence version 2.
DT   03-AUG-2022, entry version 126.
DE   RecName: Full=Adhesion G-protein coupled receptor D1;
DE   AltName: Full=G-protein coupled receptor 133;
DE   AltName: Full=G-protein coupled receptor PGR25;
DE   Flags: Precursor;
GN   Name=Adgrd1; Synonyms=Gpr133, Pgr25;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 569-698.
RX   PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA   Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA   Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA   Bergmann J.E., Gaitanaris G.A.;
RT   "The G protein-coupled receptor repertoires of human and mouse.";
RL   Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 592-903.
RC   STRAIN=C57BL/6J; TISSUE=Oviduct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Orphan receptor. Signals via G(s)-alpha family of G-proteins.
CC       {ECO:0000250|UniProtKB:Q6QNK2}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:Q6QNK2};
CC       Multi-pass membrane protein {ECO:0000255}.
CC   -!- DOMAIN: A short peptide sequence (termed the Stachel sequence) in the
CC       C-terminal part of the extra-cellular domain (ECD) functions as a
CC       tethered agonist. Upon structural changes within the ECD, e.g. due to
CC       extracellular ligand binding or mechanical movements, this
CC       intramolecular agonist is exposed to the 7TM domain, triggering G-
CC       protein activation. {ECO:0000250|UniProtKB:Q6QNK2}.
CC   -!- MISCELLANEOUS: The N-terminal domain and autocatalytic activity of
CC       ADGRD1 at the GPCR proteolysis site (GPS) are not required for G-
CC       protein coupling activity. {ECO:0000250|UniProtKB:Q6QNK2}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC35624.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AC115899; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC158913; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC151161; AAI51162.1; -; mRNA.
DR   EMBL; AY255618; AAO85130.1; -; mRNA.
DR   EMBL; AK054021; BAC35624.1; ALT_INIT; mRNA.
DR   CCDS; CCDS39289.1; -.
DR   RefSeq; NP_001074811.1; NM_001081342.1.
DR   AlphaFoldDB; Q80T32; -.
DR   STRING; 10090.ENSMUSP00000060307; -.
DR   MEROPS; P02.021; -.
DR   GlyGen; Q80T32; 13 sites.
DR   PhosphoSitePlus; Q80T32; -.
DR   PaxDb; Q80T32; -.
DR   PRIDE; Q80T32; -.
DR   ProteomicsDB; 282031; -.
DR   Antibodypedia; 19419; 181 antibodies from 27 providers.
DR   DNASU; 243277; -.
DR   Ensembl; ENSMUST00000056617; ENSMUSP00000060307; ENSMUSG00000044017.
DR   GeneID; 243277; -.
DR   KEGG; mmu:243277; -.
DR   UCSC; uc008zst.1; mouse.
DR   CTD; 283383; -.
DR   MGI; MGI:3041203; Adgrd1.
DR   VEuPathDB; HostDB:ENSMUSG00000044017; -.
DR   eggNOG; KOG4193; Eukaryota.
DR   GeneTree; ENSGT00940000159783; -.
DR   InParanoid; Q80T32; -.
DR   OMA; EGSKHLY; -.
DR   OrthoDB; 388923at2759; -.
DR   PhylomeDB; Q80T32; -.
DR   TreeFam; TF351999; -.
DR   BioGRID-ORCS; 243277; 1 hit in 73 CRISPR screens.
DR   ChiTaRS; Adgrd1; mouse.
DR   PRO; PR:Q80T32; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q80T32; protein.
DR   Bgee; ENSMUSG00000044017; Expressed in lumbar dorsal root ganglion and 102 other tissues.
DR   ExpressionAtlas; Q80T32; baseline and differential.
DR   Genevisible; Q80T32; MM.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; ISS:UniProtKB.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; ISS:UniProtKB.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISS:UniProtKB.
DR   GO; GO:0022008; P:neurogenesis; IEA:UniProt.
DR   Gene3D; 2.60.220.50; -; 1.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR017983; GPCR_2_secretin-like_CS.
DR   InterPro; IPR000203; GPS.
DR   InterPro; IPR001759; Pentraxin-related.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   SUPFAM; SSF49899; SSF49899; 1.
DR   PROSITE; PS00650; G_PROTEIN_RECEP_F2_2; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
DR   PROSITE; PS51828; PTX_2; 1.
PE   2: Evidence at transcript level;
KW   Cell membrane; Glycoprotein; Membrane; Receptor; Reference proteome;
KW   Signal; Transmembrane; Transmembrane helix.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000255"
FT   CHAIN           27..903
FT                   /note="Adhesion G-protein coupled receptor D1"
FT                   /id="PRO_0000307113"
FT   TOPO_DOM        27..599
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        600..620
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        621..632
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        633..653
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        654..662
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        663..683
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        684..701
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        702..722
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        723..740
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        741..761
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        762..789
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        790..810
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        811..813
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        814..834
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        835..903
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   DOMAIN          111..305
FT                   /note="Pentraxin (PTX)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT   DOMAIN          536..585
FT                   /note="GPS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT   REGION          862..903
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           575..583
FT                   /note="Stachel"
FT                   /evidence="ECO:0000250|UniProtKB:Q6QNK2"
FT   COMPBIAS        862..889
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        68
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        76
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        83
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        89
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        217
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        331
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        338
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        348
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        505
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        530
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        543
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        562
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   903 AA;  99277 MW;  FBF67ECFB3B5781B CRC64;
     MKDLPAFPCS WVWLLWSFCS VQVCSTQPRA QEHPGFAVLA SASHYWPLEN VDGILELQDT
     TGALRTLNLT VPLSHNATFV FTNDSAYSNL SATVDIMEGK VNKGIYLKEE KGVTFLYYGT
     YKSSCISNPA QCGPEGVTFS FFWKTQGDQT RPAPYAYGGQ VVSDGFKVCS SGGKGSVELY
     TRDNSMTWKA TFNPPGPYWT HVLFTWKSKE GLKVYVNGTL STSDPSGKVS HTYGDPHVNL
     VIGSEQDQTK RYENGAFDEF IIWERALTPD EIKMYFTAAI GKHALLSSTP PAMPTAHTVI
     PTDAYHPIIT NLTEERKRFQ RPGTVLRYLQ NVSLRLPNKS LSEETALNLT ETFLRTVGEV
     LLLPSWTHES EDNAMTLGLV DTIDTVMGHI SSNLQSREPH VTLTGSSSTA EFTVAKVLPP
     ALSAPHYRFP AHGHSYIEIP REALHSQAWT TIVGLLYHTM HYYLKNIHPT STEIPEAVNC
     RDCLLSVASH LISLEVSPPP TLSQNLSGSP LITVHLRHKL TQKQYSDATN ESNRLFLYCA
     FLNFSSGEGV WSSQGCALTE GNLTYSVCHC THLTNFAILM QVVPLKLTHG HQVALSSISY
     VGCSLSVLCL AATLVTFAVL SSVSTIRNQR YHIHANLSFA VLVAQVLLLI SFSMEPGTVP
     CQVLAVLLHY FFLTAFAWML VEGLHLYSMV IKVFGSEDSK HLYYYGIGWG CPLLICIISI
     SSSMDSYGTS DSCWLALGSG AIWAFVGPAL LVIVVNIVIL VAVTRVISHI STDSYKIHGD
     PSAFKLTAKA VAVLLPILGT SWVFGVLAVS DRALVFQYMF AILNSLQGLF IFLFHCLLNS
     EVRAAFKHKT KVWSLTSSSA RTANTKPFSS DTVNGTRPGT ASTKLSPWDK SSHSAHRVDL
     SAV
 
 
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