AGRD2_HUMAN
ID AGRD2_HUMAN Reviewed; 963 AA.
AC Q7Z7M1; Q86SL4; Q8NH12;
DT 15-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2003, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Adhesion G-protein coupled receptor D2 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G-protein coupled receptor 144;
DE AltName: Full=G-protein coupled receptor PGR24;
GN Name=ADGRD2; Synonyms=GPR144, PGR24;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=15203201; DOI=10.1016/j.ygeno.2003.12.004;
RA Bjarnadottir T.K., Fredriksson R., Hoeglund P.J., Gloriam D.E.,
RA Lagerstroem M.C., Schioeth H.B.;
RT "The human and mouse repertoire of the adhesion family of G-protein-coupled
RT receptors.";
RL Genomics 84:23-33(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-897.
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [5]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
RN [6]
RP VARIANTS SER-170 AND THR-630.
RX PubMed=28585349; DOI=10.1002/humu.23270;
RA Poirier K., Hubert L., Viot G., Rio M., Billuart P., Besmond C.,
RA Bienvenu T.;
RT "CSNK2B splice site mutations in patients cause intellectual disability
RT with or without myoclonic epilepsy.";
RL Hum. Mutat. 38:932-941(2017).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC05829.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AY278562; AAP35064.1; -; mRNA.
DR EMBL; AB065601; BAC05829.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL137846; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AY255620; AAO85132.1; -; mRNA.
DR AlphaFoldDB; Q7Z7M1; -.
DR STRING; 9606.ENSP00000335156; -.
DR ChEMBL; CHEMBL4523880; -.
DR MEROPS; P02.015; -.
DR GlyGen; Q7Z7M1; 2 sites.
DR iPTMnet; Q7Z7M1; -.
DR PhosphoSitePlus; Q7Z7M1; -.
DR BioMuta; ADGRD2; -.
DR DMDM; 59797942; -.
DR PaxDb; Q7Z7M1; -.
DR PRIDE; Q7Z7M1; -.
DR Antibodypedia; 52848; 53 antibodies from 16 providers.
DR Ensembl; ENST00000334810.5; ENSP00000335156.2; ENSG00000180264.11.
DR UCSC; uc033dhj.2; human.
DR GeneCards; ADGRD2; -.
DR HGNC; HGNC:18651; ADGRD2.
DR HPA; ENSG00000180264; Tissue enhanced (brain, pituitary gland, seminal vesicle).
DR neXtProt; NX_Q7Z7M1; -.
DR PharmGKB; PA134882616; -.
DR VEuPathDB; HostDB:ENSG00000180264; -.
DR eggNOG; KOG4193; Eukaryota.
DR HOGENOM; CLU_015074_0_0_1; -.
DR InParanoid; Q7Z7M1; -.
DR OrthoDB; 388923at2759; -.
DR PhylomeDB; Q7Z7M1; -.
DR TreeFam; TF351999; -.
DR GeneWiki; GPR144; -.
DR Pharos; Q7Z7M1; Tdark.
DR PRO; PR:Q7Z7M1; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q7Z7M1; protein.
DR Bgee; ENSG00000180264; Expressed in parotid gland and 136 other tissues.
DR ExpressionAtlas; Q7Z7M1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR Gene3D; 2.60.220.50; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR001759; Pentraxin-related.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF00354; Pentaxin; 1.
DR PRINTS; PR00895; PENTAXIN.
DR SMART; SM00303; GPS; 1.
DR SMART; SM00159; PTX; 1.
DR SUPFAM; SSF49899; SSF49899; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS51828; PTX_2; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane;
KW Receptor; Reference proteome; Transducer; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..963
FT /note="Adhesion G-protein coupled receptor D2"
FT /id="PRO_0000070338"
FT TOPO_DOM 1..662
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 663..683
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 684..691
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 692..712
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 713..720
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 721..741
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 742..762
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 763..783
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 784..800
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 801..821
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 822..857
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 858..878
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 879..880
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 881..901
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 902..963
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 116..325
FT /note="Pentraxin (PTX)"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT DOMAIN 572..648
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT REGION 18..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 271
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 634
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 146..212
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01172"
FT VARIANT 170
FT /note="P -> S"
FT /evidence="ECO:0000269|PubMed:28585349"
FT /id="VAR_083658"
FT VARIANT 630
FT /note="A -> T"
FT /evidence="ECO:0000269|PubMed:28585349"
FT /id="VAR_083659"
SQ SEQUENCE 963 AA; 104087 MW; EA7BEE0663F7A54C CRC64;
MDAPWGAGER WLHGAAVDRS GVSLGPPPTP QVNQGTLGPQ VAPVAAGEVV KTAGGVCKFS
GQRLSWWQAQ ESCEQQFGHL ALQPPDGVLA SRLRDPVWVG QREAPLRRPP QRRARTTAVL
VFDERTADRA ARLRSPLPEL AALTACTHVQ WDCASPDPAA LFSVAAPALP NALQLRAFAE
PGGVVRAALV VRGQHAPFLA AFRADGRWHH VCATWEQRGG RWALFSDGRR RAGARGLGAG
HPVPSGGILV LGQDQDSLGG GFSVRHALSG NLTDFHLWAR ALSPAQLHRA RACAPPSEGL
LFRWDPGALD VTPSLLPTVW VRLLCPVPSE ECPTWNPGPR SEGSELCLEP QPFLCCYRTE
PYRRLQDAQS WPGQDVISRV NALANDIVLL PDPLSEVHGA LSPAEASSFL GLLEHVLAME
MAPLGPAALL AVVRFLKRVV ALGAGDPELL LTGPWEQLSQ GVVSVASLVL EEQVADTWLS
LREVIGGPMA LVASVQRLAP LLSTSMTSER PRMRIQHRHA GLSGVTVIHS WFTSRVFQHT
LEGPDLEPQA PASSEEANRV QRFLSTQVGS AIISSEVWDV TGEVNVAMTF HLQHRAQSPL
FPPHPPSPYT GGAWATTGCS VAALYLDSTA CFCNHSTSFA ILLQIYEVQR GPEEESLLRT
LSFVGCGVSF CALTTTFLLF LVAGVPKSER TTVHKNLTFS LASAEGFLMT SEWAKANEVA
CVAVTVAMHF LFLVAFSWML VEGLLLWRKV VAVSMHPGPG MRLYHATGWG VPVGIVAVTL
AMLPHDYVAP GHCWLNVHTN AIWAFVGPVL FVLTANTCIL ARVVMITVSS ARRRARMLSP
QPCLQQQIWT QIWATVKPVL VLLPVLGLTW LAGILVHLSP AWAYAAVGLN SIQGLYIFLV
YAACNEEVRS ALQRMAEKKV AEVLRALGVW GGAAKEHSLP FSVLPLFLPP KPSTPRHPLK
APA
