ESC8_YEAST
ID ESC8_YEAST Reviewed; 714 AA.
AC Q08119; D6W249;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Protein ESC8;
DE AltName: Full=Establishes silent chromatin protein 8;
GN Name=ESC8; OrderedLocusNames=YOL017W;
OS Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX NCBI_TaxID=559292;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=9169874;
RA Dujon B., Albermann K., Aldea M., Alexandraki D., Ansorge W., Arino J.,
RA Benes V., Bohn C., Bolotin-Fukuhara M., Bordonne R., Boyer J., Camasses A.,
RA Casamayor A., Casas C., Cheret G., Cziepluch C., Daignan-Fornier B.,
RA Dang V.-D., de Haan M., Delius H., Durand P., Fairhead C., Feldmann H.,
RA Gaillon L., Galisson F., Gamo F.-J., Gancedo C., Goffeau A., Goulding S.E.,
RA Grivell L.A., Habbig B., Hand N.J., Hani J., Hattenhorst U., Hebling U.,
RA Hernando Y., Herrero E., Heumann K., Hiesel R., Hilger F., Hofmann B.,
RA Hollenberg C.P., Hughes B., Jauniaux J.-C., Kalogeropoulos A.,
RA Katsoulou C., Kordes E., Lafuente M.J., Landt O., Louis E.J., Maarse A.C.,
RA Madania A., Mannhaupt G., Marck C., Martin R.P., Mewes H.-W., Michaux G.,
RA Paces V., Parle-McDermott A.G., Pearson B.M., Perrin A., Pettersson B.,
RA Poch O., Pohl T.M., Poirey R., Portetelle D., Pujol A., Purnelle B.,
RA Ramezani Rad M., Rechmann S., Schwager C., Schweizer M., Sor F., Sterky F.,
RA Tarassov I.A., Teodoru C., Tettelin H., Thierry A., Tobiasch E.,
RA Tzermia M., Uhlen M., Unseld M., Valens M., Vandenbol M., Vetter I.,
RA Vlcek C., Voet M., Volckaert G., Voss H., Wambutt R., Wedler H.,
RA Wiemann S., Winsor B., Wolfe K.H., Zollner A., Zumstein E., Kleine K.;
RT "The nucleotide sequence of Saccharomyces cerevisiae chromosome XV.";
RL Nature 387:98-102(1997).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=ATCC 204508 / S288c;
RX PubMed=24374639; DOI=10.1534/g3.113.008995;
RA Engel S.R., Dietrich F.S., Fisk D.G., Binkley G., Balakrishnan R.,
RA Costanzo M.C., Dwight S.S., Hitz B.C., Karra K., Nash R.S., Weng S.,
RA Wong E.D., Lloyd P., Skrzypek M.S., Miyasato S.R., Simison M., Cherry J.M.;
RT "The reference genome sequence of Saccharomyces cerevisiae: Then and now.";
RL G3 (Bethesda) 4:389-398(2014).
RN [3]
RP FUNCTION, AND INTERACTION WITH SIR2 AND GAL11.
RX PubMed=12399377; DOI=10.1093/genetics/162.2.633;
RA Cuperus G., Shore D.;
RT "Restoration of silencing in Saccharomyces cerevisiae by tethering of a
RT novel Sir2-interacting protein, Esc8.";
RL Genetics 162:633-645(2002).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=14562095; DOI=10.1038/nature02026;
RA Huh W.-K., Falvo J.V., Gerke L.C., Carroll A.S., Howson R.W.,
RA Weissman J.S., O'Shea E.K.;
RT "Global analysis of protein localization in budding yeast.";
RL Nature 425:686-691(2003).
RN [5]
RP LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].
RX PubMed=14562106; DOI=10.1038/nature02046;
RA Ghaemmaghami S., Huh W.-K., Bower K., Howson R.W., Belle A., Dephoure N.,
RA O'Shea E.K., Weissman J.S.;
RT "Global analysis of protein expression in yeast.";
RL Nature 425:737-741(2003).
CC -!- FUNCTION: Involved in HMR and telomere silencing via the recruitment or
CC stabilizing of the SIR (silent information regulators) complex.
CC {ECO:0000269|PubMed:12399377}.
CC -!- SUBUNIT: Interacts with GAL11 and SIR2. {ECO:0000269|PubMed:12399377}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:14562095}. Nucleus
CC {ECO:0000269|PubMed:14562095}.
CC -!- MISCELLANEOUS: Present with 432 molecules/cell in log phase SD medium.
CC {ECO:0000269|PubMed:14562106}.
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DR EMBL; Z74759; CAA99016.1; -; Genomic_DNA.
DR EMBL; BK006948; DAA10765.1; -; Genomic_DNA.
DR PIR; S66699; S66699.
DR RefSeq; NP_014625.1; NM_001183271.1.
DR AlphaFoldDB; Q08119; -.
DR SMR; Q08119; -.
DR BioGRID; 34386; 138.
DR DIP; DIP-6827N; -.
DR IntAct; Q08119; 2.
DR MINT; Q08119; -.
DR STRING; 4932.YOL017W; -.
DR MaxQB; Q08119; -.
DR PaxDb; Q08119; -.
DR PRIDE; Q08119; -.
DR EnsemblFungi; YOL017W_mRNA; YOL017W; YOL017W.
DR GeneID; 854143; -.
DR KEGG; sce:YOL017W; -.
DR SGD; S000005377; ESC8.
DR VEuPathDB; FungiDB:YOL017W; -.
DR eggNOG; ENOG502QVSC; Eukaryota.
DR GeneTree; ENSGT00940000176416; -.
DR HOGENOM; CLU_471895_0_0_1; -.
DR InParanoid; Q08119; -.
DR OMA; WGLPKEW; -.
DR BioCyc; YEAST:G3O-33433-MON; -.
DR PRO; PR:Q08119; -.
DR Proteomes; UP000002311; Chromosome XV.
DR RNAct; Q08119; protein.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IPI:SGD.
DR GO; GO:0031507; P:heterochromatin assembly; IMP:SGD.
DR GO; GO:0007062; P:sister chromatid cohesion; IMP:SGD.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..714
FT /note="Protein ESC8"
FT /id="PRO_0000227694"
FT REGION 598..674
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 694..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 628..649
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 650..674
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 714 AA; 82189 MW; 5C8AD689761C30C7 CRC64;
MTEIIDLDLV DDFIKKPMVK QQKNQSSKPR VKRRGQLTFD DFRNIKIVEE PVVLSHNSSI
DESLDAATQN TKKREKYEGT CDEEMKTKEM EANMASKYSN IKTHSNDTNK VESISEHTTS
NNRPLNTLNW SPNIPLRYSD FAKFMSDETV TESNWAPPLC TPLPYAGDVM KILSFIVKFK
WVFSDDLLNL SFQDVEIGLE LKVAGHSAKN IRICQDKMNL LFCSLLRLLF CSEKRADNQT
HRNFTLKRFL SLKNPYGKLV GKLRSLIQEW GLPKEWRGNS DILSTLNFNG GGLLTMEPLD
RIILLRCMID WNCSYSALFH NEIQRLTHLK GDTGFNHQTF HASRFAMCGA NNILDSCEVL
CSLMSQKLEN RKKRKPSDKG KLSKINSQMK FLKGVRKSLS EKVTTDRLRA AVKINEEWGE
YFANEFTHTP IDDPTVDEIY KLRTSEFMIA RIPRVGDFYL PPFWIGNECS SVNTSYSFND
MSTYLNYFVK FKEEGTKILP AKTAQNENKC QLKLIYRNTP ACIRNLQFND VHFAEVPHWF
EVAGDSNSLS NFIEYLESLS SLTENDTDDT KKGIDNLIEF LKIFSIFINE TIQRITAAPT
GSTEGRHLRT SSQRRTTVHY SSDVNGDVSE ESENEVDIDV SDDYDSEYLS EENTLTRKGE
DRTDKSFGKR ELHNGAKDCD RNCDDIEIFS EPVRQLQDNS REKRSLRRNA RKGL
