ID   ESC_MUSDO               Reviewed;         428 AA.
AC   O16023;
DT   28-MAR-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1998, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Polycomb protein esc;
DE   AltName: Full=Protein extra sex combs;
GN   Name=esc;
OS   Musca domestica (House fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Muscoidea;
OC   Muscidae; Musca.
OX   NCBI_TaxID=7370;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=9343430; DOI=10.1128/mcb.17.11.6663;
RA   Ng J., Li R., Morgan K., Simon J.A.;
RT   "Evolutionary conservation and predicted structure of the Drosophila extra
RT   sex combs repressor protein.";
RL   Mol. Cell. Biol. 17:6663-6672(1997).
CC   -!- FUNCTION: Polycomb group (PcG) protein. In contrast to other PcG
CC       protein, it is specifically required during the first 6 hours of
CC       embryogenesis to establish PcG silencing. PcG proteins act by forming
CC       multiprotein complexes, which are required to maintain the
CC       transcriptionally repressive state of homeotic genes throughout
CC       development. PcG proteins are not required to initiate repression, but
CC       to maintain it during later stages of development. They probably act
CC       via a methylation of histones, rendering chromatin heritably changed in
CC       its expressibility. Component of the Esc/E(z) complex, which methylates
CC       'Lys-9' and 'Lys-27' residues of histone H3. The Esc/E(z) complex is
CC       necessary but not sufficient to recruit a functional PcG repressive
CC       complex that represses target genes, suggesting that the recruitment of
CC       the distinct PRC1 complex is also required to allow a subsequent
CC       repression (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Esc/E(z) complex, composed of Esc, E(z),
CC       Su(z)12, Rpd3, Caf1 and probably Pho. This complex is distinct from the
CC       PRC1 complex, which contains many other PcG proteins like Pc, Ph, Psc,
CC       Su(z)2. The two complexes however cooperate and interact together
CC       during the first 3 hours of development to establish PcG silencing (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the WD repeat ESC family. {ECO:0000305}.
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DR   EMBL; AF003605; AAC05333.1; -; Genomic_DNA.
DR   AlphaFoldDB; O16023; -.
DR   SMR; O16023; -.
DR   STRING; 7370.XP_005190391.1; -.
DR   VEuPathDB; VectorBase:MDOA004331; -.
DR   eggNOG; KOG1034; Eukaryota.
DR   Proteomes; UP000095301; Whole Genome Shotgun Assembly.
DR   GO; GO:0035098; C:ESC/E(Z) complex; IEA:InterPro.
DR   GO; GO:0016571; P:histone methylation; IEA:InterPro.
DR   Gene3D; 2.130.10.10; -; 1.
DR   InterPro; IPR037352; Polycomb_EED.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR001680; WD40_repeat.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   PANTHER; PTHR10253:SF5; PTHR10253:SF5; 1.
DR   Pfam; PF00400; WD40; 2.
DR   SMART; SM00320; WD40; 6.
DR   SUPFAM; SSF50978; SSF50978; 1.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 2.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE   3: Inferred from homology;
KW   Developmental protein; Nucleus; Phosphoprotein; Repeat; Repressor;
KW   Transcription; Transcription regulation; WD repeat.
FT   CHAIN           1..428
FT                   /note="Polycomb protein esc"
FT                   /id="PRO_0000050974"
FT   REPEAT          72..115
FT                   /note="WD 1"
FT   REPEAT          124..166
FT                   /note="WD 2"
FT   REPEAT          169..209
FT                   /note="WD 3"
FT   REPEAT          215..254
FT                   /note="WD 4"
FT   REPEAT          285..322
FT                   /note="WD 5"
FT   REPEAT          341..380
FT                   /note="WD 6"
FT   REPEAT          389..427
FT                   /note="WD 7"
FT   REGION          1..61
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..43
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   428 AA;  48796 MW;  5A1D09D63D1A86C2 CRC64;
     MSKVKADKQS PKENTKAENS DNESIDDTAS VATSTTSRSK SPGSRGRRQS RGHSKSKAKR
     PAYKYDCHLK EDHGQAIFGV SFNHLLGKDQ SMVFATAGSN RCNIYECPRK GGLKLIMCYA
     DPDPDEVFYT CSWSYDLKTS APLLATAGYR GVIRVIDIHR NESVGNYVGH GQAINELKFH
     PRQANLLLSG SKDHAIRLWN IQTHVCIAIF GGVEGHRDEV LSIDFDLRGE RIMSSGMDHS
     LKLWRIDTPE FKDKIEMSRT FNPNKSQLPF PTIMQHFPEF STRDIHRNYV DCVQWFGDFV
     LSKSCENSIV CWKPGQLHQT LSQLKPNDPS CTIISEFNYD ECEIWFVRFG FNPWHKIVAL
     GNQYGKVYVW ELDPSDPRHT HSSTLNNIRC TSIVRQTAFS RDATVLVWVC DDGTVWRWNR
     RNAEVHTP