ID   ESF12_ARATH             Reviewed;          82 AA.
AC   A8MQX3;
DT   03-SEP-2014, integrated into UniProtKB/Swiss-Prot.
DT   04-DEC-2007, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=EMBRYO SURROUNDING FACTOR 1.2;
DE   AltName: Full=Maternally expressed family protein 1.2;
DE   AltName: Full=Maternally expressed gene 1.2;
DE   Flags: Precursor;
GN   Name=ESF1.2; Synonyms=MEG1.2; OrderedLocusNames=At1g10745;
GN   ORFNames=F20B24, T16B5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130712; DOI=10.1038/35048500;
RA   Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA   Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA   Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA   Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA   Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA   Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA   Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA   Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA   Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA   Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA   Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA   Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA   Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA   Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA   Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT   "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL   Nature 408:816-820(2000).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION
RP   PHENOTYPE.
RX   PubMed=24723605; DOI=10.1126/science.1243005;
RA   Costa L.M., Marshall E., Tesfaye M., Silverstein K.A., Mori M., Umetsu Y.,
RA   Otterbach S.L., Papareddy R., Dickinson H.G., Boutiller K.,
RA   VandenBosch K.A., Ohki S., Gutierrez-Marcos J.F.;
RT   "Central cell-derived peptides regulate early embryo patterning in
RT   flowering plants.";
RL   Science 344:168-172(2014).
CC   -!- FUNCTION: Maternally-contributed central cell peptide regulating
CC       suspensor development and correct auxin distribution in early
CC       developing embryos. {ECO:0000269|PubMed:24723605}.
CC   -!- TISSUE SPECIFICITY: Expressed exclusively in ovule embryo sacs and in
CC       early developing endosperms. {ECO:0000269|PubMed:24723605}.
CC   -!- DEVELOPMENTAL STAGE: Primarily expressed in the central cell gamete of
CC       nonfrtilized ovules, which upon fertilization gives rise to the
CC       endosperm, and later in the micropylar endosperm, which surrounds the
CC       embryo. {ECO:0000269|PubMed:24723605}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype, due to redundancy with
CC       ESF1.1 and ESF1.3. Simultaneous down-regulation of all 3 genes by RNAi
CC       induces embryo abnormalities. {ECO:0000269|PubMed:24723605}.
CC   -!- SIMILARITY: Belongs to the MEG family. {ECO:0000305}.
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DR   EMBL; AC007354; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AC009398; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CP002684; AEE28640.1; -; Genomic_DNA.
DR   RefSeq; NP_001077510.1; NM_001084041.2.
DR   AlphaFoldDB; A8MQX3; -.
DR   SMR; A8MQX3; -.
DR   STRING; 3702.AT1G10745.1; -.
DR   PaxDb; A8MQX3; -.
DR   PRIDE; A8MQX3; -.
DR   EnsemblPlants; AT1G10745.1; AT1G10745.1; AT1G10745.
DR   GeneID; 5007679; -.
DR   Gramene; AT1G10745.1; AT1G10745.1; AT1G10745.
DR   KEGG; ath:AT1G10745; -.
DR   Araport; AT1G10745; -.
DR   TAIR; locus:4010713428; AT1G10745.
DR   HOGENOM; CLU_183999_1_0_1; -.
DR   OMA; QKECESN; -.
DR   OrthoDB; 1619994at2759; -.
DR   PhylomeDB; A8MQX3; -.
DR   PRO; PR:A8MQX3; -.
DR   Proteomes; UP000006548; Chromosome 1.
DR   ExpressionAtlas; A8MQX3; baseline.
DR   GO; GO:0000578; P:embryonic axis specification; IMP:UniProtKB.
DR   GO; GO:0010098; P:suspensor development; IMP:UniProtKB.
DR   InterPro; IPR041608; ESF1_brassicaceae.
DR   Pfam; PF18209; ESF1; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; Disulfide bond; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..82
FT                   /note="EMBRYO SURROUNDING FACTOR 1.2"
FT                   /id="PRO_0000430060"
FT   DISULFID        40..56
FT                   /evidence="ECO:0000250"
FT   DISULFID        45..77
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..71
FT                   /evidence="ECO:0000250"
FT   DISULFID        57..64
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   82 AA;  9386 MW;  5220AD5518826E30 CRC64;
     MKSQTVLISI FIFSFFALHQ CMQMDVGEIE GSNKISIGKC VPAQCSVSFF KRDCWCCFRD
     QSMCSKTQKE CESNPRCPPL KF