ID   ESF2_ASPCL              Reviewed;         368 AA.
AC   A1C807;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Pre-rRNA-processing protein esf2;
DE   AltName: Full=18S rRNA factor 2;
GN   Name=esf2; ORFNames=ACLA_075670;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Involved in the small subunit (SSU) processome assembly and
CC       function, and in the 18S rRNA synthesis. Required for the early
CC       cleavages at sites A0, A1 and A2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESF2/ABP1 family. {ECO:0000305}.
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DR   EMBL; DS027045; EAW14528.1; -; Genomic_DNA.
DR   RefSeq; XP_001275954.1; XM_001275953.1.
DR   AlphaFoldDB; A1C807; -.
DR   STRING; 5057.CADACLAP00006991; -.
DR   EnsemblFungi; EAW14528; EAW14528; ACLA_075670.
DR   GeneID; 4707655; -.
DR   KEGG; act:ACLA_075670; -.
DR   VEuPathDB; FungiDB:ACLA_075670; -.
DR   eggNOG; KOG3152; Eukaryota.
DR   HOGENOM; CLU_054086_0_1_1; -.
DR   OMA; TRKHNDF; -.
DR   OrthoDB; 1377351at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12263; RRM_ABT1_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039119; ABT1/Esf2.
DR   InterPro; IPR034353; ABT1/ESF2_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   PANTHER; PTHR12311; PTHR12311; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..368
FT                   /note="Pre-rRNA-processing protein esf2"
FT                   /id="PRO_0000285362"
FT   DOMAIN          148..238
FT                   /note="RRM"
FT   REGION          1..144
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        105..132
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   368 AA;  41481 MW;  2BB1F7B6C14D25BF CRC64;
     MTTRKRNEFL DIASEDEDGS DRGYDSEAAE ESKGRFTKRR RTHTRADDLS DEESDLDVSD
     EDDERDSKAK IKTKSKRKTA KHGDEIATDD SSADEDDLQE DQYLDASAQP GSPSHTDSHT
     TTTTTTTSKP QKKKPLAKVK PPKKNKTGVV YLSSLPPYLK PFALKSMLET RGFEPITKVF
     LTPEVPSAAG PRRRSNKRKT YADGWVEFAS KKTAKICAET LNASIVGGRK GGWYHDDVWN
     MKYLRGFKWA DLMEQVQRER SEREARRRIE DTRARKEDKV FLEGVEHGKV LQGIQKKNEE
     KRRRQAEARA DAEAAVAATA ATSDAGNGPQ GVKVRRLFKQ NEVKVGRDKI KGDATLEDDT
     KRVLSKIF