ID   ESF2_COCIM              Reviewed;         356 AA.
AC   Q1DJR2; J3K349;
DT   01-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Pre-rRNA-processing protein ESF2;
DE   AltName: Full=18S rRNA factor 2;
GN   Name=ESF2; ORFNames=CIMG_09451;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Involved in the small subunit (SSU) processome assembly and
CC       function, and in the 18S rRNA synthesis. Required for the early
CC       cleavages at sites A0, A1 and A2 (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ESF2/ABP1 family. {ECO:0000305}.
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DR   EMBL; GG704915; EAS28247.3; -; Genomic_DNA.
DR   RefSeq; XP_001239830.1; XM_001239829.2.
DR   AlphaFoldDB; Q1DJR2; -.
DR   STRING; 246410.Q1DJR2; -.
DR   EnsemblFungi; EAS28247; EAS28247; CIMG_09451.
DR   GeneID; 4559134; -.
DR   KEGG; cim:CIMG_09451; -.
DR   VEuPathDB; FungiDB:CIMG_09451; -.
DR   InParanoid; Q1DJR2; -.
DR   OMA; HILSNFG; -.
DR   OrthoDB; 1377351at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005730; C:nucleolus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0006364; P:rRNA processing; IEA:UniProtKB-KW.
DR   CDD; cd12263; RRM_ABT1_like; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR039119; ABT1/Esf2.
DR   InterPro; IPR034353; ABT1/ESF2_RRM.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   PANTHER; PTHR12311; PTHR12311; 1.
DR   SUPFAM; SSF54928; SSF54928; 1.
PE   3: Inferred from homology;
KW   Nucleus; Reference proteome; Ribosome biogenesis; RNA-binding;
KW   rRNA processing.
FT   CHAIN           1..356
FT                   /note="Pre-rRNA-processing protein ESF2"
FT                   /id="PRO_0000285369"
FT   DOMAIN          146..235
FT                   /note="RRM"
FT   REGION          1..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          298..318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        29..45
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..102
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        106..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   356 AA;  39985 MW;  91B9C906A6622545 CRC64;
     MTTRKRTDFW DIPSDEEDND VGYDSEAAQE SKGRSSVSKS TTAPSRLRRP SKRRKLSITE
     HGGGSDNGSG SESEDEGIDT ESDEPEQEEQ IEEGEQEDEE AESPIEPTSK STPAATATTT
     TSSTDIDTTT STASNPKLKP KKNKTGVIYF SSLPPYLKPF ALKSLLIARG FGPITKIFLT
     PSVQSSSAGK RSNKRRMYSD GWVEFASKRT AKICAETLNA TIVGGKKGGW YHDDVWNMKY
     LRGFKWADLM EQVQRERKET EARRRVEDAK ARKEEKVFLA GVEKGKVFEG IRKKREEKEK
     KLRAGGEGDM GDGGKVSLDK PRRVFRQNEV RDREKDGVRK ERKVDEDVQR VLAKIF