ID   ESG2_TRYBB              Reviewed;         329 AA.
AC   P04478;
DT   13-AUG-1987, integrated into UniProtKB/Swiss-Prot.
DT   13-AUG-1987, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=VSG expression site-associated protein 221A;
DE   AltName: Full=ESAG protein;
DE   Flags: Precursor;
OS   Trypanosoma brucei brucei.
OC   Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC   Trypanosomatida; Trypanosomatidae; Trypanosoma.
OX   NCBI_TaxID=5702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=2861910; DOI=10.1016/s0092-8674(85)80113-6;
RA   Cully D.F., Ip H.S., Cross G.A.M.;
RT   "Coordinate transcription of variant surface glycoprotein genes and an
RT   expression site associated gene family in Trypanosoma brucei.";
RL   Cell 42:173-182(1985).
CC   -!- FUNCTION: Not known but may be related to activation of the variant
CC       surface glycoprotein genes.
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DR   EMBL; M11452; AAA30191.1; -; mRNA.
DR   PIR; A03395; VMUT21.
DR   AlphaFoldDB; P04478; -.
DR   SMR; P04478; -.
DR   InterPro; IPR004922; ESAG.
DR   Pfam; PF03238; ESAG1; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Signal.
FT   SIGNAL          1..23
FT   CHAIN           24..329
FT                   /note="VSG expression site-associated protein 221A"
FT                   /id="PRO_0000021205"
FT   CARBOHYD        73
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        294
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        308
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   329 AA;  36604 MW;  4D19F59477D9CEE8 CRC64;
     MKVEIVELVV LLFSVTCVDA WLQGADCTRV ADHKEHAPVT EAVCYLRCLS DALNKLYSEG
     EKKLLVTEEV YANASLILDD MEGRAGESST YLSVIRGVME EQTDRLEKLI SYGNKMGNLV
     AKAGGLFAAL EDSLKEVRKE IPGALIKTNK YYTSVAEIVR TVWEDVGEIL WKETEAKCGS
     QKVEGVGEIQ TECGAHTCPF ADNGVAASAV DKYKGHCLYV GRNSYLRHCF NLPRGRLYRH
     GPVNTLGDAL EWEENWSDYM NFELTVKVQK IFGPLIASFD VGIAPSTLAE MINNITSLQS
     RFNEVHSNFT SILFTTKLKT EVYNTDSTI