ESM1_HUMAN
ID ESM1_HUMAN Reviewed; 184 AA.
AC Q9NQ30; B2R4G3; Q15330; Q3V4E3; Q96ES3;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Endothelial cell-specific molecule 1;
DE Short=ESM-1;
DE Flags: Precursor;
GN Name=ESM1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC TISSUE=Umbilical vein endothelial cell;
RX PubMed=8702785; DOI=10.1074/jbc.271.34.20458;
RA Lassalle P., Molet S., Janin A., Vander-Heyden J.E., Tavernier J.,
RA Fiers W., Devos R.E., Tonnel A.-B.;
RT "ESM-1 is a novel human endothelial cell-specific molecule expressed in
RT lung and regulated by cytokines.";
RL J. Biol. Chem. 271:20458-20464(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Leukocyte;
RA Vedrenne C., Kervoaze G., Lassalle P.;
RT "Sequencing of the human ESM-1 gene and analysis of its 5' flanking
RT region.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
RA Depontieu F., Grigoriu B., Scherpereel A., Adam E., Lafitte J.J.,
RA Ouatas T., Delehedde M., Lyon M., Copin M.C., Janin A., Tonnel A.B.,
RA Tsicopoulos A., Lassalle P.;
RT "Exon 2 of the endocan gene contributes to tumorigenesis and its expression
RT is increased in human lung tumor vascular cells.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP FUNCTION.
RX PubMed=20616313; DOI=10.1161/circresaha.110.217257;
RA Brutsch R., Liebler S.S., Wustehube J., Bartol A., Herberich S.E.,
RA Adam M.G., Telzerow A., Augustin H.G., Fischer A.;
RT "Integrin cytoplasmic domain-associated protein-1 attenuates sprouting
RT angiogenesis.";
RL Circ. Res. 107:592-601(2010).
RN [8]
RP GLYCOSYLATION AT SER-156.
RX PubMed=20581009; DOI=10.1093/glycob/cwq100;
RA Sarrazin S., Lyon M., Deakin J.A., Guerrini M., Lassalle P., Delehedde M.,
RA Lortat-Jacob H.;
RT "Characterization and binding activity of the chondroitin/dermatan sulfate
RT chain from Endocan, a soluble endothelial proteoglycan.";
RL Glycobiology 20:1380-1388(2010).
CC -!- FUNCTION: Involved in angiogenesis; promotes angiogenic sprouting. May
CC have potent implications in lung endothelial cell-leukocyte
CC interactions. {ECO:0000269|PubMed:20616313}.
CC -!- SUBUNIT: Monomer.
CC -!- INTERACTION:
CC Q9NQ30; O43184-4: ADAM12; NbExp=3; IntAct=EBI-12260294, EBI-12006944;
CC Q9NQ30; Q49AR9: ANKS1A; NbExp=3; IntAct=EBI-12260294, EBI-11954519;
CC Q9NQ30; P29972: AQP1; NbExp=3; IntAct=EBI-12260294, EBI-745213;
CC Q9NQ30; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-12260294, EBI-11524452;
CC Q9NQ30; Q9H5Z6-2: FAM124B; NbExp=3; IntAct=EBI-12260294, EBI-11986315;
CC Q9NQ30; O43559: FRS3; NbExp=3; IntAct=EBI-12260294, EBI-725515;
CC Q9NQ30; Q8WUI4-6: HDAC7; NbExp=3; IntAct=EBI-12260294, EBI-12094670;
CC Q9NQ30; P49639: HOXA1; NbExp=3; IntAct=EBI-12260294, EBI-740785;
CC Q9NQ30; O60333-2: KIF1B; NbExp=3; IntAct=EBI-12260294, EBI-10975473;
CC Q9NQ30; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-12260294, EBI-16439278;
CC Q9NQ30; Q16656-4: NRF1; NbExp=3; IntAct=EBI-12260294, EBI-11742836;
CC Q9NQ30; Q7Z417: NUFIP2; NbExp=3; IntAct=EBI-12260294, EBI-1210753;
CC Q9NQ30; O43741: PRKAB2; NbExp=3; IntAct=EBI-12260294, EBI-1053424;
CC Q9NQ30; Q9Y3C5: RNF11; NbExp=3; IntAct=EBI-12260294, EBI-396669;
CC Q9NQ30; A8MV65-2: VGLL3; NbExp=3; IntAct=EBI-12260294, EBI-11957216;
CC Q9NQ30; O76024: WFS1; NbExp=3; IntAct=EBI-12260294, EBI-720609;
CC Q9NQ30; P25490: YY1; NbExp=3; IntAct=EBI-12260294, EBI-765538;
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9NQ30-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NQ30-2; Sequence=VSP_042631;
CC -!- TISSUE SPECIFICITY: Expressed in lung, on the vascular capillary
CC network within alveolar walls, and also at lower level in kidney.
CC -!- INDUCTION: By TNF and IL1B/interleukin-1 beta, but not IL4/interleukin-
CC 4.
CC -!- PTM: May contain intrachain disulfide bonds.
CC -!- PTM: O-glycosylated; contains chondroitin sulfate and dermatan sulfate.
CC {ECO:0000269|PubMed:20581009}.
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DR EMBL; X89426; CAA61597.1; -; mRNA.
DR EMBL; AJ401091; CAB94771.1; -; Genomic_DNA.
DR EMBL; AJ401092; CAB94771.1; JOINED; Genomic_DNA.
DR EMBL; AJ973643; CAJ13737.1; -; mRNA.
DR EMBL; AK300634; BAG62324.1; -; mRNA.
DR EMBL; AK311817; BAG34760.1; -; mRNA.
DR EMBL; AC010436; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC034238; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC011989; AAH11989.1; -; mRNA.
DR CCDS; CCDS3963.1; -. [Q9NQ30-1]
DR CCDS; CCDS47206.1; -. [Q9NQ30-2]
DR RefSeq; NP_001129076.1; NM_001135604.1. [Q9NQ30-2]
DR RefSeq; NP_008967.1; NM_007036.4. [Q9NQ30-1]
DR AlphaFoldDB; Q9NQ30; -.
DR BioGRID; 116265; 15.
DR IntAct; Q9NQ30; 17.
DR STRING; 9606.ENSP00000370812; -.
DR GlyGen; Q9NQ30; 1 site.
DR iPTMnet; Q9NQ30; -.
DR PhosphoSitePlus; Q9NQ30; -.
DR BioMuta; ESM1; -.
DR DMDM; 13431509; -.
DR MassIVE; Q9NQ30; -.
DR PaxDb; Q9NQ30; -.
DR PeptideAtlas; Q9NQ30; -.
DR PRIDE; Q9NQ30; -.
DR ProteomicsDB; 82061; -. [Q9NQ30-1]
DR ProteomicsDB; 82062; -. [Q9NQ30-2]
DR Antibodypedia; 23370; 268 antibodies from 27 providers.
DR DNASU; 11082; -.
DR Ensembl; ENST00000381403.4; ENSP00000370810.4; ENSG00000164283.13. [Q9NQ30-2]
DR Ensembl; ENST00000381405.5; ENSP00000370812.4; ENSG00000164283.13. [Q9NQ30-1]
DR GeneID; 11082; -.
DR KEGG; hsa:11082; -.
DR MANE-Select; ENST00000381405.5; ENSP00000370812.4; NM_007036.5; NP_008967.1.
DR UCSC; uc003jpk.4; human. [Q9NQ30-1]
DR CTD; 11082; -.
DR DisGeNET; 11082; -.
DR GeneCards; ESM1; -.
DR HGNC; HGNC:3466; ESM1.
DR HPA; ENSG00000164283; Tissue enhanced (kidney, thyroid gland).
DR MIM; 601521; gene.
DR neXtProt; NX_Q9NQ30; -.
DR OpenTargets; ENSG00000164283; -.
DR PharmGKB; PA27883; -.
DR VEuPathDB; HostDB:ENSG00000164283; -.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00390000018810; -.
DR HOGENOM; CLU_103395_0_0_1; -.
DR InParanoid; Q9NQ30; -.
DR OMA; GMECKQT; -.
DR OrthoDB; 1508747at2759; -.
DR PhylomeDB; Q9NQ30; -.
DR PathwayCommons; Q9NQ30; -.
DR SignaLink; Q9NQ30; -.
DR BioGRID-ORCS; 11082; 8 hits in 1061 CRISPR screens.
DR GeneWiki; ESM1; -.
DR GenomeRNAi; 11082; -.
DR Pharos; Q9NQ30; Tbio.
DR PRO; PR:Q9NQ30; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q9NQ30; protein.
DR Bgee; ENSG00000164283; Expressed in islet of Langerhans and 109 other tissues.
DR ExpressionAtlas; Q9NQ30; baseline and differential.
DR Genevisible; Q9NQ30; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005171; F:hepatocyte growth factor receptor binding; IPI:UniProtKB.
DR GO; GO:0005178; F:integrin binding; IPI:UniProtKB.
DR GO; GO:0001525; P:angiogenesis; IEP:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IDA:UniProtKB.
DR GO; GO:1902204; P:positive regulation of hepatocyte growth factor receptor signaling pathway; IDA:UniProtKB.
DR GO; GO:0002040; P:sprouting angiogenesis; IMP:UniProtKB.
DR InterPro; IPR038850; ESM1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR PANTHER; PTHR15428; PTHR15428; 1.
DR Pfam; PF00219; IGFBP; 1.
DR SMART; SM00121; IB; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Angiogenesis; Disulfide bond; Glycoprotein;
KW Proteoglycan; Reference proteome; Secreted; Signal.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..184
FT /note="Endothelial cell-specific molecule 1"
FT /id="PRO_0000014394"
FT DOMAIN 24..102
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT CARBOHYD 156
FT /note="O-linked (Xyl...) (chondroitin sulfate) serine"
FT /evidence="ECO:0000269|PubMed:20581009"
FT VAR_SEQ 101..150
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039, ECO:0000303|Ref.3"
FT /id="VSP_042631"
FT CONFLICT 44
FT /note="K -> E (in Ref. 6; AAH11989)"
FT /evidence="ECO:0000305"
FT CONFLICT 151
FT /note="Missing (in Ref. 2; CAB94771)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 184 AA; 20095 MW; 2AD15EDEC74BC8CE CRC64;
MKSVLLLTTL LVPAHLVAAW SNNYAVDCPQ HCDSSECKSS PRCKRTVLDD CGCCRVCAAG
RGETCYRTVS GMDGMKCGPG LRCQPSNGED PFGEEFGICK DCPYGTFGMD CRETCNCQSG
ICDRGTGKCL KFPFFQYSVT KSSNRFVSLT EHDMASGDGN IVREEVVKEN AAGSPVMRKW
LNPR
