ESM1_MOUSE
ID ESM1_MOUSE Reviewed; 184 AA.
AC Q9QYY7;
DT 27-APR-2001, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Endothelial cell-specific molecule 1;
DE Short=ESM-1;
DE Flags: Precursor;
GN Name=Esm1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ; TISSUE=Lung;
RA Lassalle P.;
RL Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Involved in angiogenesis; promotes angiogenic sprouting. May
CC have potent implications in lung endothelial cell-leukocyte
CC interactions (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- PTM: O-glycosylated; contains chondroitin sulfate and dermatan sulfate.
CC {ECO:0000250}.
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DR EMBL; AJ249354; CAB60730.1; -; mRNA.
DR EMBL; AK002913; BAB22452.1; -; mRNA.
DR EMBL; BC051919; AAH51919.1; -; mRNA.
DR CCDS; CCDS26784.1; -.
DR RefSeq; NP_076101.1; NM_023612.3.
DR AlphaFoldDB; Q9QYY7; -.
DR STRING; 10090.ENSMUSP00000040187; -.
DR GlyGen; Q9QYY7; 1 site.
DR PhosphoSitePlus; Q9QYY7; -.
DR EPD; Q9QYY7; -.
DR PaxDb; Q9QYY7; -.
DR PRIDE; Q9QYY7; -.
DR ProteomicsDB; 275951; -.
DR Antibodypedia; 23370; 268 antibodies from 27 providers.
DR DNASU; 71690; -.
DR Ensembl; ENSMUST00000038144; ENSMUSP00000040187; ENSMUSG00000042379.
DR GeneID; 71690; -.
DR KEGG; mmu:71690; -.
DR UCSC; uc007rxe.1; mouse.
DR CTD; 11082; -.
DR MGI; MGI:1918940; Esm1.
DR VEuPathDB; HostDB:ENSMUSG00000042379; -.
DR eggNOG; KOG1218; Eukaryota.
DR GeneTree; ENSGT00390000018810; -.
DR HOGENOM; CLU_103395_0_0_1; -.
DR InParanoid; Q9QYY7; -.
DR OMA; GMECKQT; -.
DR OrthoDB; 1508747at2759; -.
DR PhylomeDB; Q9QYY7; -.
DR BioGRID-ORCS; 71690; 0 hits in 74 CRISPR screens.
DR PRO; PR:Q9QYY7; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q9QYY7; protein.
DR Bgee; ENSMUSG00000042379; Expressed in pineal body and 114 other tissues.
DR ExpressionAtlas; Q9QYY7; baseline and differential.
DR Genevisible; Q9QYY7; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005171; F:hepatocyte growth factor receptor binding; ISO:MGI.
DR GO; GO:0005178; F:integrin binding; ISO:MGI.
DR GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:1902204; P:positive regulation of hepatocyte growth factor receptor signaling pathway; ISO:MGI.
DR GO; GO:0002040; P:sprouting angiogenesis; ISO:MGI.
DR InterPro; IPR038850; ESM1.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000867; IGFBP-like.
DR PANTHER; PTHR15428; PTHR15428; 1.
DR Pfam; PF00219; IGFBP; 1.
DR SMART; SM00121; IB; 1.
DR SUPFAM; SSF57184; SSF57184; 1.
DR PROSITE; PS51323; IGFBP_N_2; 1.
PE 2: Evidence at transcript level;
KW Angiogenesis; Glycoprotein; Proteoglycan; Reference proteome; Secreted;
KW Signal.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..184
FT /note="Endothelial cell-specific molecule 1"
FT /id="PRO_0000014395"
FT DOMAIN 24..102
FT /note="IGFBP N-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00653"
FT REGION 145..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 157
FT /note="O-linked (Xyl...) (chondroitin sulfate) serine"
FT /evidence="ECO:0000250"
SQ SEQUENCE 184 AA; 20043 MW; 0F54F7629678D278 CRC64;
MKSLLLLTTL LVPLHLGMAW SAKYAVDCPE HCDKTECRSS LRCKRTVLDD CGCCQVCAAG
PGETCYRTVS GMDGVKCGPG LKCHFYSEED DFGDEFGICK DCPYGTFGME CKETCNCQSG
ICDRVTGRCL DFPFFQYAAA KSPSRTSASH TERDSASGDG NAVREEIGEG NAARPSVMKW
LNPR
