ESM5_DROME
ID ESM5_DROME Reviewed; 178 AA.
AC P13096; Q56K28; Q56K51; Q56K70; Q56K88; Q56K96; Q56KF0; Q56KF1; Q56KG3;
AC Q56KH0; Q56KI0; Q56KJ4; Q56KK0; Q56KQ1; Q56KQ5; Q56KS5; Q56KV2; Q56KV5;
AC Q56KV7; Q56KW6; Q56KX1; Q56KZ8; Q5S489; Q5S4I5; Q5S4J7; Q9VBI8;
DT 01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1990, sequence version 1.
DT 03-AUG-2022, entry version 199.
DE RecName: Full=Enhancer of split m5 protein;
DE Short=E(spl)m5;
GN Name=E(spl)m5-HLH {ECO:0000312|FlyBase:FBgn0002631}; Synonyms=HLHm5;
GN ORFNames=CG6096 {ECO:0000312|FlyBase:FBgn0002631};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=2540957; DOI=10.1002/j.1460-2075.1989.tb03365.x;
RA Klaembt C., Knust E., Tietze K., Campos-Ortega J.A.;
RT "Closely related transcripts encoded by the neurogenic gene complex
RT enhancer of split of Drosophila melanogaster.";
RL EMBO J. 8:203-210(1989).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-2 AND GLN-169.
RC STRAIN=NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41,
RC NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13,
RC NVIII-m15, and NVIII-m19;
RX PubMed=15537803; DOI=10.1093/molbev/msi046;
RA Macdonald S.J., Long A.D.;
RT "Identifying signatures of selection at the enhancer of split neurogenic
RT gene complex in Drosophila.";
RL Mol. Biol. Evol. 22:607-619(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 2-130, AND VARIANT VAL-2.
RC STRAIN=Nv2001_f0501, Nv2001_f0502, Nv2001_f0503, Nv2001_f0505,
RC Nv2001_f0506, Nv2001_f0507, Nv2001_f0508, Nv2001_f0509, Nv2001_f0513,
RC Nv2001_f0514, Nv2001_f0515, Nv2001_f0516, Nv2001_f0517, Nv2001_f0518,
RC Nv2001_f0519, Nv2001_f0520, Nv2001_f0521, Nv2001_f0522, Nv2001_f0523,
RC Nv2001_f0524, Nv2001_f0525, Nv2001_f0526, Nv2001_f0527, Nv2001_f0529,
RC Nv2001_f0530, Nv2001_f0531, Nv2001_f0532, Nv2001_f0533, Nv2001_f0534,
RC Nv2001_f0535, Nv2001_f0536, Nv2001_f0537, Nv2001_f0538, Nv2001_f0539,
RC Nv2001_f0540, Nv2001_f0541, Nv2001_f0543, Nv2001_f0544, Nv2001_f0545,
RC Nv2001_f0546, Nv2001_f0547, Nv2001_f0548, Nv2001_f0549, Nv2001_f0550,
RC Nv2001_f0551, Nv2001_f0552, Nv2001_f0553, Nv2001_f0554, Nv2001_f0555,
RC Nv2001_f0556, Nv2001_f0557, Nv2001_f0558, Nv2001_f0559, Nv2001_f0560,
RC Nv2001_f0561, Nv2001_f0562, Nv2001_f0563, Nv2001_f0564, Nv2001_f0565,
RC Nv2001_f0566, Nv2001_f0567, Nv2001_f0568, Nv2001_f0569, Nv2001_f0570,
RC Nv2001_f0571, Nv2001_f0572, Nv2001_f0573, Nv2001_f0574, Nv2001_f0575,
RC Nv2001_f0576, Nv2001_f0577, Nv2001_f0578, Nv2001_f0579, Nv2001_f0580,
RC Nv2001_f0581, Nv2001_f0582, Nv2001_f0583, Nv2001_f0584, Nv2001_f0585,
RC Nv2001_f0586, Nv2001_f0587, Nv2001_f0588, Nv2001_f0589, Nv2001_f0590,
RC Nv2001_f0591, Nv2001_f0592, Nv2001_f0593, Nv2001_f0594, Nv2001_f0596,
RC Nv2001_f0597, Nv2001_f0598, Nv2001_f0600, Nv2001_f0601, Nv2001_f0603,
RC Nv2001_f0604, Nv2001_f0605, Nv2001_f0606, Nv2001_f0607, Nv2001_f0608,
RC Nv2001_f0609, Nv2001_f0610, Nv2001_f0611, Nv2001_f0612, Nv2001_f0613,
RC Nv2001_f0614, Nv2001_f0615, Nv2001_f0616, Nv2001_f0617, Nv2001_f0618,
RC Nv2001_f0619, Nv2001_f0620, Nv2001_f0621, Nv2001_f0622, Nv2001_f0623,
RC Nv2001_f0625, Nv2001_f0626, Nv2001_f0627, Nv2001_f0628, Nv2001_f0629,
RC Nv2001_f0630, Nv2001_f0631, Nv2001_f0632, Nv2001_f0633, Nv2001_f0634,
RC Nv2001_f0635, Nv2001_f0636, Nv2001_f0637, Nv2001_f0638, Nv2001_f0639,
RC Nv2001_f0640, Nv2001_f0641, Nv2001_f0642, Nv2001_f0643, Nv2001_f0644,
RC Nv2001_f0645, Nv2001_f0646, Nv2001_f0647, Nv2001_f0648, Nv2001_f0649,
RC Nv2001_f0650, Nv2001_f0651, Nv2001_f0652, Nv2001_f0653, Nv2001_f0654,
RC Nv2001_f0655, Nv2001_f0656, Nv2001_f0658, Nv2001_f0659, Nv2001_f0660,
RC Nv2001_f0661, Nv2001_f0662, Nv2001_f0663, Nv2001_f0664, Nv2001_f0665,
RC Nv2001_f0666, Nv2001_f0668, Nv2001_f0669, Nv2001_f0670, Nv2001_f0671,
RC Nv2001_f0672, Nv2001_f0673, Nv2001_f0674, Nv2001_f0675, Nv2001_f0676,
RC Nv2001_f0677, Nv2001_f0678, Nv2001_f0679, Nv2001_f0680, Nv2001_f0682,
RC Nv2001_f0683, Nv2001_f0684, Nv2001_f0685, Nv2001_f0686, Nv2001_f0687,
RC Nv2001_f0688, Nv2001_f0689, Nv2001_f0692, Nv2001_f0693, Nv2001_f0694,
RC Nv2001_f0695, Nv2001_f0696, Nv2001_f0698, Nv2001_f0699, Nv2001_f0700,
RC Nv2001_f0701, Nv2001_f0702, Nv2001_f0703, Nv2001_f0704, Nv2001_f0705,
RC Nv2001_f0706, Nv2001_f0707, Nv2001_f0708, Nv2001_f0710, Nv2001_f0712,
RC Nv2001_f0713, Nv2001_f0714, Nv2001_f0715, Nv2001_f0716, Nv2001_f0717,
RC Nv2001_f0718, Nv2001_f0719, Nv2001_f0720, Nv2001_f0721, Nv2001_f0723,
RC Nv2001_f0724, Nv2001_f0726, Nv2001_f0727, Nv2001_f0729, Nv2001_f0730,
RC Nv2001_f0732, Nv2001_f0733, Nv2001_f0734, Nv2001_f0735, Nv2001_f0736,
RC Nv2001_f0737, Nv2001_f0738, Nv2001_f0739, Nv2001_f0741, Nv2001_f0742,
RC Nv2001_f0743, Nv2001_f0744, Nv2001_f0745, Nv2001_f0746, Nv2001_f0747,
RC Nv2001_f0748, Nv2001_f0749, Nv2001_f0750, Nv2001_f0752, Nv2001_f0753,
RC Nv2001_f0754, Nv2001_f0755, Nv2001_f0756, Nv2001_f0757, Nv2001_f0758,
RC Nv2001_f0759, Nv2001_f0760, Nv2001_f0762, Nv2001_f0763, Nv2001_f0764,
RC Nv2001_f0765, Nv2001_f0766, Nv2001_f0767, Nv2001_f0769, Nv2001_f0770,
RC Nv2001_f0771, Nv2001_f0772, Nv2001_f0773, Nv2001_f0775, Nv2001_f0776,
RC Nv2001_f0777, Nv2001_f0780, Nv2001_f0781, Nv2001_f0782, Nv2001_f0783,
RC Nv2001_f0784, Nv2001_f0785, Nv2001_f0786, Nv2001_f0787, Nv2001_f0788,
RC Nv2001_f0790, Nv2001_f0791, Nv2001_f0793, Nv2001_f0794, Nv2001_f0795,
RC Nv2001_f0797, Nv2001_f0798, Nv2001_f0799, Nv2001_f0801, Nv2001_f0802,
RC Nv2001_f0803, Nv2001_f0804, Nv2001_f0805, Nv2001_f0806, Nv2001_f0807,
RC Nv2001_f0808, Nv2001_f0809, Nv2001_f0810, Nv2001_f0811, Nv2001_f0812,
RC Nv2001_f0814, Nv2001_f0815, Nv2001_f0818, Nv2001_f0819, Nv2001_f0820,
RC Nv2001_f0822, Nv2001_f0823, Nv2001_f0825, Nv2001_f0826, Nv2001_f0827,
RC Nv2001_f0828, Nv2001_f0830, Nv2001_f0832, Nv2001_f0833, Nv2001_f0834,
RC Nv2001_f0836, Nv2001_f0837, Nv2001_f0838, Nv2001_f0839, Nv2001_f0840,
RC Nv2001_f0841, Nv2001_f0844, Nv2001_f0845, Nv2001_f0846, Nv2001_f0847,
RC Nv2001_f0848, Nv2001_f0849, Nv2001_f0850, Nv2001_f0851, Nv2001_f0852,
RC Nv2001_f0853, Nv2001_f0854, Nv2001_f0855, Nv2001_f0856, Nv2001_f0857,
RC Nv2001_f0858, Nv2001_f0859, Nv2001_f0860, Nv2001_f0861, Nv2001_f0862,
RC Nv2001_f0863, Nv2001_f0865, Nv2001_f0866, Nv2001_f0867, Nv2001_f0868,
RC Nv2001_f0869, Nv2001_f0870, Nv2001_f0871, Nv2001_f0872, Nv2001_f0873,
RC Nv2001_f0874, and Nv2001_f1002;
RX PubMed=16356268; DOI=10.1186/gb-2005-6-12-r105;
RA Macdonald S.J., Pastinen T., Genissel A., Cornforth T.W., Long A.D.;
RT "A low-cost open-source SNP genotyping platform for association mapping
RT applications.";
RL Genome Biol. 6:R105.1-R105.11(2005).
RN [7]
RP DOMAIN WRPW MOTIF.
RX PubMed=8001118; DOI=10.1016/0092-8674(94)90070-1;
RA Paroush Z., Finley R.L. Jr., Kidd T., Wainwright S.M., Ingham P.W.,
RA Brent R., Ish-Horowicz D.;
RT "Groucho is required for Drosophila neurogenesis, segmentation, and sex
RT determination and interacts directly with hairy-related bHLH proteins.";
RL Cell 79:805-815(1994).
CC -!- FUNCTION: Participates in the control of cell fate choice by
CC uncommitted neuroectodermal cells in the embryo. Transcriptional
CC repressor. Binds DNA on N-box motifs: 5'-CACNAG-3'.
CC {ECO:0000269|PubMed:2540957}.
CC -!- SUBUNIT: Transcription repression requires formation of a complex with
CC a corepressor protein (Groucho). Forms homodimers.
CC -!- INTERACTION:
CC P13096; P16371: gro; NbExp=3; IntAct=EBI-104760, EBI-153866;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the time when separation of neural
CC and epidermal precursors cells occurs. Mesectodermal expression appears
CC shortly before the onset of gastrulation. {ECO:0000269|PubMed:2540957}.
CC -!- DOMAIN: The orange domain and the basic helix-loop-helix motif mediate
CC repression of specific transcriptional activators, such as basic helix-
CC loop-helix protein dimers. {ECO:0000269|PubMed:8001118}.
CC -!- DOMAIN: The C-terminal WRPW motif is a transcriptional repression
CC domain necessary for the interaction with Groucho, a transcriptional
CC corepressor recruited to specific target DNA by Hairy-related proteins.
CC {ECO:0000269|PubMed:8001118}.
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DR EMBL; X16552; CAA34552.1; -; Genomic_DNA.
DR EMBL; AY779906; AAV59049.1; -; Genomic_DNA.
DR EMBL; AY779907; AAV59061.1; -; Genomic_DNA.
DR EMBL; AY779908; AAV59073.1; -; Genomic_DNA.
DR EMBL; AY779909; AAV59085.1; -; Genomic_DNA.
DR EMBL; AY779910; AAV59097.1; -; Genomic_DNA.
DR EMBL; AY779911; AAV59109.1; -; Genomic_DNA.
DR EMBL; AY779912; AAV59121.1; -; Genomic_DNA.
DR EMBL; AY779913; AAV59133.1; -; Genomic_DNA.
DR EMBL; AY779914; AAV59145.1; -; Genomic_DNA.
DR EMBL; AY779915; AAV59157.1; -; Genomic_DNA.
DR EMBL; AY779916; AAV59169.1; -; Genomic_DNA.
DR EMBL; AY779917; AAV59181.1; -; Genomic_DNA.
DR EMBL; AY779918; AAV59193.1; -; Genomic_DNA.
DR EMBL; AY779919; AAV59205.1; -; Genomic_DNA.
DR EMBL; AY779920; AAV59217.1; -; Genomic_DNA.
DR EMBL; AY779921; AAV59229.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56552.1; -; Genomic_DNA.
DR EMBL; AY070597; AAL48068.1; -; mRNA.
DR EMBL; AY906443; AAX60789.1; -; Genomic_DNA.
DR EMBL; AY906444; AAX60790.1; -; Genomic_DNA.
DR EMBL; AY906445; AAX60791.1; -; Genomic_DNA.
DR EMBL; AY906446; AAX60792.1; -; Genomic_DNA.
DR EMBL; AY906447; AAX60793.1; -; Genomic_DNA.
DR EMBL; AY906448; AAX60794.1; -; Genomic_DNA.
DR EMBL; AY906449; AAX60795.1; -; Genomic_DNA.
DR EMBL; AY906450; AAX60796.1; -; Genomic_DNA.
DR EMBL; AY906451; AAX60797.1; -; Genomic_DNA.
DR EMBL; AY906452; AAX60798.1; -; Genomic_DNA.
DR EMBL; AY906453; AAX60799.1; -; Genomic_DNA.
DR EMBL; AY906454; AAX60800.1; -; Genomic_DNA.
DR EMBL; AY906455; AAX60801.1; -; Genomic_DNA.
DR EMBL; AY906456; AAX60802.1; -; Genomic_DNA.
DR EMBL; AY906457; AAX60803.1; -; Genomic_DNA.
DR EMBL; AY906458; AAX60804.1; -; Genomic_DNA.
DR EMBL; AY906459; AAX60805.1; -; Genomic_DNA.
DR EMBL; AY906460; AAX60806.1; -; Genomic_DNA.
DR EMBL; AY906461; AAX60807.1; -; Genomic_DNA.
DR EMBL; AY906462; AAX60808.1; -; Genomic_DNA.
DR EMBL; AY906463; AAX60809.1; -; Genomic_DNA.
DR EMBL; AY906464; AAX60810.1; -; Genomic_DNA.
DR EMBL; AY906465; AAX60811.1; -; Genomic_DNA.
DR EMBL; AY906466; AAX60812.1; -; Genomic_DNA.
DR EMBL; AY906467; AAX60813.1; -; Genomic_DNA.
DR EMBL; AY906468; AAX60814.1; -; Genomic_DNA.
DR EMBL; AY906469; AAX60815.1; -; Genomic_DNA.
DR EMBL; AY906470; AAX60816.1; -; Genomic_DNA.
DR EMBL; AY906471; AAX60817.1; -; Genomic_DNA.
DR EMBL; AY906472; AAX60818.1; -; Genomic_DNA.
DR EMBL; AY906473; AAX60819.1; -; Genomic_DNA.
DR EMBL; AY906474; AAX60820.1; -; Genomic_DNA.
DR EMBL; AY906475; AAX60821.1; -; Genomic_DNA.
DR EMBL; AY906476; AAX60822.1; -; Genomic_DNA.
DR EMBL; AY906477; AAX60823.1; -; Genomic_DNA.
DR EMBL; AY906478; AAX60824.1; -; Genomic_DNA.
DR EMBL; AY906479; AAX60825.1; -; Genomic_DNA.
DR EMBL; AY906480; AAX60826.1; -; Genomic_DNA.
DR EMBL; AY906481; AAX60827.1; -; Genomic_DNA.
DR EMBL; AY906482; AAX60828.1; -; Genomic_DNA.
DR EMBL; AY906483; AAX60829.1; -; Genomic_DNA.
DR EMBL; AY906484; AAX60830.1; -; Genomic_DNA.
DR EMBL; AY906485; AAX60831.1; -; Genomic_DNA.
DR EMBL; AY906486; AAX60832.1; -; Genomic_DNA.
DR EMBL; AY906487; AAX60833.1; -; Genomic_DNA.
DR EMBL; AY906488; AAX60834.1; -; Genomic_DNA.
DR EMBL; AY906489; AAX60835.1; -; Genomic_DNA.
DR EMBL; AY906490; AAX60836.1; -; Genomic_DNA.
DR EMBL; AY906491; AAX60837.1; -; Genomic_DNA.
DR EMBL; AY906492; AAX60838.1; -; Genomic_DNA.
DR EMBL; AY906493; AAX60839.1; -; Genomic_DNA.
DR EMBL; AY906494; AAX60840.1; -; Genomic_DNA.
DR EMBL; AY906495; AAX60841.1; -; Genomic_DNA.
DR EMBL; AY906496; AAX60842.1; -; Genomic_DNA.
DR EMBL; AY906497; AAX60843.1; -; Genomic_DNA.
DR EMBL; AY906498; AAX60844.1; -; Genomic_DNA.
DR EMBL; AY906499; AAX60845.1; -; Genomic_DNA.
DR EMBL; AY906500; AAX60846.1; -; Genomic_DNA.
DR EMBL; AY906501; AAX60847.1; -; Genomic_DNA.
DR EMBL; AY906502; AAX60848.1; -; Genomic_DNA.
DR EMBL; AY906503; AAX60849.1; -; Genomic_DNA.
DR EMBL; AY906504; AAX60850.1; -; Genomic_DNA.
DR EMBL; AY906505; AAX60851.1; -; Genomic_DNA.
DR EMBL; AY906506; AAX60852.1; -; Genomic_DNA.
DR EMBL; AY906507; AAX60853.1; -; Genomic_DNA.
DR EMBL; AY906508; AAX60854.1; -; Genomic_DNA.
DR EMBL; AY906509; AAX60855.1; -; Genomic_DNA.
DR EMBL; AY906510; AAX60856.1; -; Genomic_DNA.
DR EMBL; AY906511; AAX60857.1; -; Genomic_DNA.
DR EMBL; AY906512; AAX60858.1; -; Genomic_DNA.
DR EMBL; AY906513; AAX60859.1; -; Genomic_DNA.
DR EMBL; AY906514; AAX60860.1; -; Genomic_DNA.
DR EMBL; AY906515; AAX60861.1; -; Genomic_DNA.
DR EMBL; AY906516; AAX60862.1; -; Genomic_DNA.
DR EMBL; AY906517; AAX60863.1; -; Genomic_DNA.
DR EMBL; AY906518; AAX60864.1; -; Genomic_DNA.
DR EMBL; AY906519; AAX60865.1; -; Genomic_DNA.
DR EMBL; AY906520; AAX60866.1; -; Genomic_DNA.
DR EMBL; AY906521; AAX60867.1; -; Genomic_DNA.
DR EMBL; AY906522; AAX60868.1; -; Genomic_DNA.
DR EMBL; AY906523; AAX60869.1; -; Genomic_DNA.
DR EMBL; AY906524; AAX60870.1; -; Genomic_DNA.
DR EMBL; AY906525; AAX60871.1; -; Genomic_DNA.
DR EMBL; AY906526; AAX60872.1; -; Genomic_DNA.
DR EMBL; AY906527; AAX60873.1; -; Genomic_DNA.
DR EMBL; AY906528; AAX60874.1; -; Genomic_DNA.
DR EMBL; AY906529; AAX60875.1; -; Genomic_DNA.
DR EMBL; AY906530; AAX60876.1; -; Genomic_DNA.
DR EMBL; AY906531; AAX60877.1; -; Genomic_DNA.
DR EMBL; AY906532; AAX60878.1; -; Genomic_DNA.
DR EMBL; AY906533; AAX60879.1; -; Genomic_DNA.
DR EMBL; AY906534; AAX60880.1; -; Genomic_DNA.
DR EMBL; AY906535; AAX60881.1; -; Genomic_DNA.
DR EMBL; AY906536; AAX60882.1; -; Genomic_DNA.
DR EMBL; AY906537; AAX60883.1; -; Genomic_DNA.
DR EMBL; AY906538; AAX60884.1; -; Genomic_DNA.
DR EMBL; AY906539; AAX60885.1; -; Genomic_DNA.
DR EMBL; AY906540; AAX60886.1; -; Genomic_DNA.
DR EMBL; AY906541; AAX60887.1; -; Genomic_DNA.
DR EMBL; AY906542; AAX60888.1; -; Genomic_DNA.
DR EMBL; AY906543; AAX60889.1; -; Genomic_DNA.
DR EMBL; AY906544; AAX60890.1; -; Genomic_DNA.
DR EMBL; AY906545; AAX60891.1; -; Genomic_DNA.
DR EMBL; AY906546; AAX60892.1; -; Genomic_DNA.
DR EMBL; AY906547; AAX60893.1; -; Genomic_DNA.
DR EMBL; AY906548; AAX60894.1; -; Genomic_DNA.
DR EMBL; AY906549; AAX60895.1; -; Genomic_DNA.
DR EMBL; AY906550; AAX60896.1; -; Genomic_DNA.
DR EMBL; AY906551; AAX60897.1; -; Genomic_DNA.
DR EMBL; AY906552; AAX60898.1; -; Genomic_DNA.
DR EMBL; AY906553; AAX60899.1; -; Genomic_DNA.
DR EMBL; AY906554; AAX60900.1; -; Genomic_DNA.
DR EMBL; AY906555; AAX60901.1; -; Genomic_DNA.
DR EMBL; AY906556; AAX60902.1; -; Genomic_DNA.
DR EMBL; AY906557; AAX60903.1; -; Genomic_DNA.
DR EMBL; AY906558; AAX60904.1; -; Genomic_DNA.
DR EMBL; AY906559; AAX60905.1; -; Genomic_DNA.
DR EMBL; AY906560; AAX60906.1; -; Genomic_DNA.
DR EMBL; AY906561; AAX60907.1; -; Genomic_DNA.
DR EMBL; AY906562; AAX60908.1; -; Genomic_DNA.
DR EMBL; AY906563; AAX60909.1; -; Genomic_DNA.
DR EMBL; AY906564; AAX60910.1; -; Genomic_DNA.
DR EMBL; AY906565; AAX60911.1; -; Genomic_DNA.
DR EMBL; AY906566; AAX60912.1; -; Genomic_DNA.
DR EMBL; AY906567; AAX60913.1; -; Genomic_DNA.
DR EMBL; AY906568; AAX60914.1; -; Genomic_DNA.
DR EMBL; AY906569; AAX60915.1; -; Genomic_DNA.
DR EMBL; AY906570; AAX60916.1; -; Genomic_DNA.
DR EMBL; AY906571; AAX60917.1; -; Genomic_DNA.
DR EMBL; AY906572; AAX60918.1; -; Genomic_DNA.
DR EMBL; AY906573; AAX60919.1; -; Genomic_DNA.
DR EMBL; AY906574; AAX60920.1; -; Genomic_DNA.
DR EMBL; AY906575; AAX60921.1; -; Genomic_DNA.
DR EMBL; AY906576; AAX60922.1; -; Genomic_DNA.
DR EMBL; AY906577; AAX60923.1; -; Genomic_DNA.
DR EMBL; AY906578; AAX60924.1; -; Genomic_DNA.
DR EMBL; AY906579; AAX60925.1; -; Genomic_DNA.
DR EMBL; AY906580; AAX60926.1; -; Genomic_DNA.
DR EMBL; AY906581; AAX60927.1; -; Genomic_DNA.
DR EMBL; AY906582; AAX60928.1; -; Genomic_DNA.
DR EMBL; AY906583; AAX60929.1; -; Genomic_DNA.
DR EMBL; AY906584; AAX60930.1; -; Genomic_DNA.
DR EMBL; AY906585; AAX60931.1; -; Genomic_DNA.
DR EMBL; AY906586; AAX60932.1; -; Genomic_DNA.
DR EMBL; AY906587; AAX60933.1; -; Genomic_DNA.
DR EMBL; AY906588; AAX60934.1; -; Genomic_DNA.
DR EMBL; AY906589; AAX60935.1; -; Genomic_DNA.
DR EMBL; AY906590; AAX60936.1; -; Genomic_DNA.
DR EMBL; AY906591; AAX60937.1; -; Genomic_DNA.
DR EMBL; AY906592; AAX60938.1; -; Genomic_DNA.
DR EMBL; AY906593; AAX60939.1; -; Genomic_DNA.
DR EMBL; AY906594; AAX60940.1; -; Genomic_DNA.
DR EMBL; AY906595; AAX60941.1; -; Genomic_DNA.
DR EMBL; AY906596; AAX60942.1; -; Genomic_DNA.
DR EMBL; AY906597; AAX60943.1; -; Genomic_DNA.
DR EMBL; AY906598; AAX60944.1; -; Genomic_DNA.
DR EMBL; AY906599; AAX60945.1; -; Genomic_DNA.
DR EMBL; AY906600; AAX60946.1; -; Genomic_DNA.
DR EMBL; AY906601; AAX60947.1; -; Genomic_DNA.
DR EMBL; AY906602; AAX60948.1; -; Genomic_DNA.
DR EMBL; AY906603; AAX60949.1; -; Genomic_DNA.
DR EMBL; AY906604; AAX60950.1; -; Genomic_DNA.
DR EMBL; AY906605; AAX60951.1; -; Genomic_DNA.
DR EMBL; AY906606; AAX60952.1; -; Genomic_DNA.
DR EMBL; AY906607; AAX60953.1; -; Genomic_DNA.
DR EMBL; AY906608; AAX60954.1; -; Genomic_DNA.
DR EMBL; AY906609; AAX60955.1; -; Genomic_DNA.
DR EMBL; AY906610; AAX60956.1; -; Genomic_DNA.
DR EMBL; AY906611; AAX60957.1; -; Genomic_DNA.
DR EMBL; AY906612; AAX60958.1; -; Genomic_DNA.
DR EMBL; AY906613; AAX60959.1; -; Genomic_DNA.
DR EMBL; AY906614; AAX60960.1; -; Genomic_DNA.
DR EMBL; AY906615; AAX60961.1; -; Genomic_DNA.
DR EMBL; AY906616; AAX60962.1; -; Genomic_DNA.
DR EMBL; AY906617; AAX60963.1; -; Genomic_DNA.
DR EMBL; AY906618; AAX60964.1; -; Genomic_DNA.
DR EMBL; AY906619; AAX60965.1; -; Genomic_DNA.
DR EMBL; AY906620; AAX60966.1; -; Genomic_DNA.
DR EMBL; AY906621; AAX60967.1; -; Genomic_DNA.
DR EMBL; AY906622; AAX60968.1; -; Genomic_DNA.
DR EMBL; AY906623; AAX60969.1; -; Genomic_DNA.
DR EMBL; AY906624; AAX60970.1; -; Genomic_DNA.
DR EMBL; AY906625; AAX60971.1; -; Genomic_DNA.
DR EMBL; AY906626; AAX60972.1; -; Genomic_DNA.
DR EMBL; AY906627; AAX60973.1; -; Genomic_DNA.
DR EMBL; AY906628; AAX60974.1; -; Genomic_DNA.
DR EMBL; AY906629; AAX60975.1; -; Genomic_DNA.
DR EMBL; AY906630; AAX60976.1; -; Genomic_DNA.
DR EMBL; AY906631; AAX60977.1; -; Genomic_DNA.
DR EMBL; AY906632; AAX60978.1; -; Genomic_DNA.
DR EMBL; AY906633; AAX60979.1; -; Genomic_DNA.
DR EMBL; AY906634; AAX60980.1; -; Genomic_DNA.
DR EMBL; AY906635; AAX60981.1; -; Genomic_DNA.
DR EMBL; AY906636; AAX60982.1; -; Genomic_DNA.
DR EMBL; AY906637; AAX60983.1; -; Genomic_DNA.
DR EMBL; AY906638; AAX60984.1; -; Genomic_DNA.
DR EMBL; AY906639; AAX60985.1; -; Genomic_DNA.
DR EMBL; AY906640; AAX60986.1; -; Genomic_DNA.
DR EMBL; AY906641; AAX60987.1; -; Genomic_DNA.
DR EMBL; AY906642; AAX60988.1; -; Genomic_DNA.
DR EMBL; AY906643; AAX60989.1; -; Genomic_DNA.
DR EMBL; AY906644; AAX60990.1; -; Genomic_DNA.
DR EMBL; AY906645; AAX60991.1; -; Genomic_DNA.
DR EMBL; AY906646; AAX60992.1; -; Genomic_DNA.
DR EMBL; AY906647; AAX60993.1; -; Genomic_DNA.
DR EMBL; AY906648; AAX60994.1; -; Genomic_DNA.
DR EMBL; AY906649; AAX60995.1; -; Genomic_DNA.
DR EMBL; AY906650; AAX60996.1; -; Genomic_DNA.
DR EMBL; AY906651; AAX60997.1; -; Genomic_DNA.
DR EMBL; AY906652; AAX60998.1; -; Genomic_DNA.
DR EMBL; AY906653; AAX60999.1; -; Genomic_DNA.
DR EMBL; AY906654; AAX61000.1; -; Genomic_DNA.
DR EMBL; AY906655; AAX61001.1; -; Genomic_DNA.
DR EMBL; AY906656; AAX61002.1; -; Genomic_DNA.
DR EMBL; AY906657; AAX61003.1; -; Genomic_DNA.
DR EMBL; AY906658; AAX61004.1; -; Genomic_DNA.
DR EMBL; AY906659; AAX61005.1; -; Genomic_DNA.
DR EMBL; AY906660; AAX61006.1; -; Genomic_DNA.
DR EMBL; AY906661; AAX61007.1; -; Genomic_DNA.
DR EMBL; AY906662; AAX61008.1; -; Genomic_DNA.
DR EMBL; AY906663; AAX61009.1; -; Genomic_DNA.
DR EMBL; AY906664; AAX61010.1; -; Genomic_DNA.
DR EMBL; AY906665; AAX61011.1; -; Genomic_DNA.
DR EMBL; AY906666; AAX61012.1; -; Genomic_DNA.
DR EMBL; AY906667; AAX61013.1; -; Genomic_DNA.
DR EMBL; AY906668; AAX61014.1; -; Genomic_DNA.
DR EMBL; AY906669; AAX61015.1; -; Genomic_DNA.
DR EMBL; AY906670; AAX61016.1; -; Genomic_DNA.
DR EMBL; AY906671; AAX61017.1; -; Genomic_DNA.
DR EMBL; AY906672; AAX61018.1; -; Genomic_DNA.
DR EMBL; AY906673; AAX61019.1; -; Genomic_DNA.
DR EMBL; AY906674; AAX61020.1; -; Genomic_DNA.
DR EMBL; AY906675; AAX61021.1; -; Genomic_DNA.
DR EMBL; AY906676; AAX61022.1; -; Genomic_DNA.
DR EMBL; AY906677; AAX61023.1; -; Genomic_DNA.
DR EMBL; AY906678; AAX61024.1; -; Genomic_DNA.
DR EMBL; AY906679; AAX61025.1; -; Genomic_DNA.
DR EMBL; AY906680; AAX61026.1; -; Genomic_DNA.
DR EMBL; AY906681; AAX61027.1; -; Genomic_DNA.
DR EMBL; AY906682; AAX61028.1; -; Genomic_DNA.
DR EMBL; AY906683; AAX61029.1; -; Genomic_DNA.
DR EMBL; AY906684; AAX61030.1; -; Genomic_DNA.
DR EMBL; AY906685; AAX61031.1; -; Genomic_DNA.
DR EMBL; AY906686; AAX61032.1; -; Genomic_DNA.
DR EMBL; AY906687; AAX61033.1; -; Genomic_DNA.
DR EMBL; AY906688; AAX61034.1; -; Genomic_DNA.
DR EMBL; AY906689; AAX61035.1; -; Genomic_DNA.
DR EMBL; AY906690; AAX61036.1; -; Genomic_DNA.
DR EMBL; AY906691; AAX61037.1; -; Genomic_DNA.
DR EMBL; AY906692; AAX61038.1; -; Genomic_DNA.
DR EMBL; AY906693; AAX61039.1; -; Genomic_DNA.
DR EMBL; AY906694; AAX61040.1; -; Genomic_DNA.
DR EMBL; AY906695; AAX61041.1; -; Genomic_DNA.
DR EMBL; AY906696; AAX61042.1; -; Genomic_DNA.
DR EMBL; AY906697; AAX61043.1; -; Genomic_DNA.
DR EMBL; AY906698; AAX61044.1; -; Genomic_DNA.
DR EMBL; AY906699; AAX61045.1; -; Genomic_DNA.
DR EMBL; AY906700; AAX61046.1; -; Genomic_DNA.
DR EMBL; AY906701; AAX61047.1; -; Genomic_DNA.
DR EMBL; AY906702; AAX61048.1; -; Genomic_DNA.
DR EMBL; AY906703; AAX61049.1; -; Genomic_DNA.
DR EMBL; AY906704; AAX61050.1; -; Genomic_DNA.
DR EMBL; AY906705; AAX61051.1; -; Genomic_DNA.
DR EMBL; AY906706; AAX61052.1; -; Genomic_DNA.
DR EMBL; AY906707; AAX61053.1; -; Genomic_DNA.
DR EMBL; AY906708; AAX61054.1; -; Genomic_DNA.
DR EMBL; AY906709; AAX61055.1; -; Genomic_DNA.
DR EMBL; AY906711; AAX61057.1; -; Genomic_DNA.
DR EMBL; AY906712; AAX61058.1; -; Genomic_DNA.
DR EMBL; AY906713; AAX61059.1; -; Genomic_DNA.
DR EMBL; AY906714; AAX61060.1; -; Genomic_DNA.
DR EMBL; AY906715; AAX61061.1; -; Genomic_DNA.
DR EMBL; AY906716; AAX61062.1; -; Genomic_DNA.
DR EMBL; AY906717; AAX61063.1; -; Genomic_DNA.
DR EMBL; AY906718; AAX61064.1; -; Genomic_DNA.
DR EMBL; AY906719; AAX61065.1; -; Genomic_DNA.
DR EMBL; AY906720; AAX61066.1; -; Genomic_DNA.
DR EMBL; AY906721; AAX61067.1; -; Genomic_DNA.
DR EMBL; AY906722; AAX61068.1; -; Genomic_DNA.
DR EMBL; AY906723; AAX61069.1; -; Genomic_DNA.
DR EMBL; AY906724; AAX61070.1; -; Genomic_DNA.
DR EMBL; AY906725; AAX61071.1; -; Genomic_DNA.
DR EMBL; AY906726; AAX61072.1; -; Genomic_DNA.
DR EMBL; AY906727; AAX61073.1; -; Genomic_DNA.
DR EMBL; AY906728; AAX61074.1; -; Genomic_DNA.
DR EMBL; AY906729; AAX61075.1; -; Genomic_DNA.
DR EMBL; AY906730; AAX61076.1; -; Genomic_DNA.
DR EMBL; AY906731; AAX61077.1; -; Genomic_DNA.
DR EMBL; AY906732; AAX61078.1; -; Genomic_DNA.
DR EMBL; AY906733; AAX61079.1; -; Genomic_DNA.
DR EMBL; AY906734; AAX61080.1; -; Genomic_DNA.
DR EMBL; AY906735; AAX61081.1; -; Genomic_DNA.
DR EMBL; AY906736; AAX61082.1; -; Genomic_DNA.
DR EMBL; AY906737; AAX61083.1; -; Genomic_DNA.
DR EMBL; AY906738; AAX61084.1; -; Genomic_DNA.
DR EMBL; AY906739; AAX61085.1; -; Genomic_DNA.
DR EMBL; AY906740; AAX61086.1; -; Genomic_DNA.
DR EMBL; AY906741; AAX61087.1; -; Genomic_DNA.
DR EMBL; AY906742; AAX61088.1; -; Genomic_DNA.
DR EMBL; AY906743; AAX61089.1; -; Genomic_DNA.
DR EMBL; AY906745; AAX61091.1; -; Genomic_DNA.
DR EMBL; AY906746; AAX61092.1; -; Genomic_DNA.
DR EMBL; AY906747; AAX61093.1; -; Genomic_DNA.
DR EMBL; AY906748; AAX61094.1; -; Genomic_DNA.
DR EMBL; AY906749; AAX61095.1; -; Genomic_DNA.
DR EMBL; AY906750; AAX61096.1; -; Genomic_DNA.
DR EMBL; AY906751; AAX61097.1; -; Genomic_DNA.
DR EMBL; AY906752; AAX61098.1; -; Genomic_DNA.
DR EMBL; AY906753; AAX61099.1; -; Genomic_DNA.
DR EMBL; AY906754; AAX61100.1; -; Genomic_DNA.
DR EMBL; AY906755; AAX61101.1; -; Genomic_DNA.
DR EMBL; AY906756; AAX61102.1; -; Genomic_DNA.
DR EMBL; AY906757; AAX61103.1; -; Genomic_DNA.
DR EMBL; AY906758; AAX61104.1; -; Genomic_DNA.
DR EMBL; AY906759; AAX61105.1; -; Genomic_DNA.
DR EMBL; AY906760; AAX61106.1; -; Genomic_DNA.
DR EMBL; AY906761; AAX61107.1; -; Genomic_DNA.
DR EMBL; AY906762; AAX61108.1; -; Genomic_DNA.
DR EMBL; AY906763; AAX61109.1; -; Genomic_DNA.
DR EMBL; AY906764; AAX61110.1; -; Genomic_DNA.
DR EMBL; AY906765; AAX61111.1; -; Genomic_DNA.
DR EMBL; AY906766; AAX61112.1; -; Genomic_DNA.
DR EMBL; AY906767; AAX61113.1; -; Genomic_DNA.
DR EMBL; AY906768; AAX61114.1; -; Genomic_DNA.
DR EMBL; AY906769; AAX61115.1; -; Genomic_DNA.
DR EMBL; AY906770; AAX61116.1; -; Genomic_DNA.
DR EMBL; AY906771; AAX61117.1; -; Genomic_DNA.
DR EMBL; AY906772; AAX61118.1; -; Genomic_DNA.
DR EMBL; AY906773; AAX61119.1; -; Genomic_DNA.
DR EMBL; AY906774; AAX61120.1; -; Genomic_DNA.
DR EMBL; AY906775; AAX61121.1; -; Genomic_DNA.
DR PIR; S03629; S03629.
DR RefSeq; NP_524511.1; NM_079787.3.
DR AlphaFoldDB; P13096; -.
DR BioGRID; 68058; 15.
DR DIP; DIP-627N; -.
DR ELM; P13096; -.
DR IntAct; P13096; 15.
DR MINT; P13096; -.
DR STRING; 7227.FBpp0084352; -.
DR PaxDb; P13096; -.
DR EnsemblMetazoa; FBtr0084979; FBpp0084352; FBgn0002631.
DR GeneID; 43158; -.
DR KEGG; dme:Dmel_CG6096; -.
DR CTD; 43158; -.
DR FlyBase; FBgn0002631; E(spl)m5-HLH.
DR VEuPathDB; VectorBase:FBgn0002631; -.
DR eggNOG; KOG4304; Eukaryota.
DR HOGENOM; CLU_068550_2_2_1; -.
DR InParanoid; P13096; -.
DR OMA; ACQRVHD; -.
DR OrthoDB; 1378299at2759; -.
DR PhylomeDB; P13096; -.
DR SignaLink; P13096; -.
DR BioGRID-ORCS; 43158; 0 hits in 3 CRISPR screens.
DR ChiTaRS; E(spl)m5-HLH; fly.
DR GenomeRNAi; 43158; -.
DR PRO; PR:P13096; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002631; Expressed in embryonic optic lobe primordium and 38 other tissues.
DR ExpressionAtlas; P13096; baseline and differential.
DR Genevisible; P13096; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IDA:FlyBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IPI:FlyBase.
DR GO; GO:0042803; F:protein homodimerization activity; IPI:FlyBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..178
FT /note="Enhancer of split m5 protein"
FT /id="PRO_0000127172"
FT DOMAIN 18..73
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 89..122
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 135..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 175..178
FT /note="WRPW motif"
FT COMPBIAS 135..168
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 2
FT /note="A -> V (in strain: Nv2001_f0696, NVIII-46 and NVIII-
FT 24)"
FT /evidence="ECO:0000269|PubMed:15537803,
FT ECO:0000269|PubMed:16356268"
FT VARIANT 169
FT /note="P -> Q (in strain: NVIII-46 and NVIII-24)"
FT /evidence="ECO:0000269|PubMed:15537803"
SQ SEQUENCE 178 AA; 19923 MW; 19363D0F6043C84F CRC64;
MAPQSNNSTT FVSKTQHYLK VKKPLLERQR RARMNKCLDT LKTLVAEFQG DDAILRMDKA
EMLEAALVFM RKQVVKQQAP VSPLPMDSFK NGYMNAVSEI SRVMACTPAM SVDVGKTVMT
HLGVEFQRML QADQVQTSVT TSTPRPLSPA SSGYHSDNED SQSAASPKPV EETMWRPW
