ESM6_DROME
ID ESM6_DROME Reviewed; 70 AA.
AC O97179; C9QP91; C9QPH4; Q5S4C4; Q5S4H2; Q5S4J6; Q9VBI7;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2000, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=Enhancer of split m6 protein {ECO:0000303|PubMed:10072784};
DE Short=E(spl)m6 {ECO:0000303|PubMed:10072784};
GN Name=E(spl)m6-BFM {ECO:0000312|FlyBase:FBgn0002632};
GN Synonyms=m6 {ECO:0000303|PubMed:10072784};
GN ORFNames=CG8354 {ECO:0000312|FlyBase:FBgn0002632};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT HIS-21.
RC TISSUE=Embryo;
RX PubMed=10072784; DOI=10.1016/s0925-4773(98)00212-3;
RA Wurmbach E., Wech I., Preiss A.;
RT "The Enhancer of split complex of Drosophila melanogaster harbors three
RT classes of Notch responsive genes.";
RL Mech. Dev. 80:171-180(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS LEU-20 AND HIS-21.
RC STRAIN=NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41,
RC NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13,
RC NVIII-m15, and NVIII-m19;
RX PubMed=15537803; DOI=10.1093/molbev/msi046;
RA Macdonald S.J., Long A.D.;
RT "Identifying signatures of selection at the enhancer of split neurogenic
RT gene complex in Drosophila.";
RL Mol. Biol. Evol. 22:607-619(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [4]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Carlson J.W., Booth B., Frise E., Park S., Sandler J., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (FEB-2010) to the EMBL/GenBank/DDBJ databases.
CC -!- DEVELOPMENTAL STAGE: Expressed at the time when separation of neural
CC and epidermal precursors cells occurs. Expressed within neuronal cells
CC in the embryo. Later in development, accumulates within the developing
CC central nervous system. After germ band retraction, found in brain,
CC ventral nerve cord and in presumptive peripheral nervous system.
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DR EMBL; AJ012204; CAB39177.1; -; Genomic_DNA.
DR EMBL; AY779906; AAV59056.1; -; Genomic_DNA.
DR EMBL; AY779907; AAV59068.1; -; Genomic_DNA.
DR EMBL; AY779908; AAV59080.1; -; Genomic_DNA.
DR EMBL; AY779909; AAV59092.1; -; Genomic_DNA.
DR EMBL; AY779910; AAV59104.1; -; Genomic_DNA.
DR EMBL; AY779911; AAV59116.1; -; Genomic_DNA.
DR EMBL; AY779912; AAV59128.1; -; Genomic_DNA.
DR EMBL; AY779913; AAV59140.1; -; Genomic_DNA.
DR EMBL; AY779914; AAV59152.1; -; Genomic_DNA.
DR EMBL; AY779915; AAV59164.1; -; Genomic_DNA.
DR EMBL; AY779916; AAV59176.1; -; Genomic_DNA.
DR EMBL; AY779917; AAV59188.1; -; Genomic_DNA.
DR EMBL; AY779918; AAV59200.1; -; Genomic_DNA.
DR EMBL; AY779919; AAV59212.1; -; Genomic_DNA.
DR EMBL; AY779920; AAV59224.1; -; Genomic_DNA.
DR EMBL; AY779921; AAV59236.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56553.1; -; Genomic_DNA.
DR EMBL; BT099973; ACX53654.1; -; mRNA.
DR EMBL; BT100088; ACX61629.3; -; mRNA.
DR RefSeq; NP_524512.2; NM_079788.3.
DR AlphaFoldDB; O97179; -.
DR BioGRID; 68059; 1.
DR STRING; 7227.FBpp0084333; -.
DR PaxDb; O97179; -.
DR DNASU; 43159; -.
DR EnsemblMetazoa; FBtr0084959; FBpp0084333; FBgn0002632.
DR GeneID; 43159; -.
DR KEGG; dme:Dmel_CG8354; -.
DR CTD; 43159; -.
DR FlyBase; FBgn0002632; E(spl)m6-BFM.
DR VEuPathDB; VectorBase:FBgn0002632; -.
DR eggNOG; ENOG502TBGY; Eukaryota.
DR HOGENOM; CLU_2560759_0_0_1; -.
DR InParanoid; O97179; -.
DR OMA; EDHLVIC; -.
DR OrthoDB; 1599376at2759; -.
DR PhylomeDB; O97179; -.
DR BioGRID-ORCS; 43159; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43159; -.
DR PRO; PR:O97179; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002632; Expressed in adult muscle precursor cell (Drosophila) and 12 other tissues.
DR Genevisible; O97179; DM.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:FlyBase.
DR GO; GO:0001708; P:cell fate specification; IMP:FlyBase.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IMP:FlyBase.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Neurogenesis; Reference proteome.
FT CHAIN 1..70
FT /note="Enhancer of split m6 protein"
FT /id="PRO_0000087060"
FT VARIANT 20
FT /note="S -> L (in strain: NVIII-5, NVIII-9, NVIII-46 and
FT NVIII-41)"
FT /evidence="ECO:0000269|PubMed:15537803"
FT VARIANT 21
FT /note="Q -> H (in strain: NVIII-1, NVIII-2, NVIII-5, NVIII-
FT 9, NVIII-18, NVIII-22, NVIII-24, NVIII-41, NVIII-42, NVIII-
FT 46, NVIII-m11, NVIII-m12, NVIII-m13, NVIII-m15 and NVIII-
FT m19)"
FT /evidence="ECO:0000269|PubMed:10072784,
FT ECO:0000269|PubMed:15537803"
SQ SEQUENCE 70 AA; 8059 MW; 03EBCC8B54BC01AA CRC64;
MSKVKNLLAK MLQRFGKNSS QADSQRYDSL EEIAQNQANE RMLRATQVGL EEHLVICLET
EAGSFYWHSQ
