ESMA_DROME
ID ESMA_DROME Reviewed; 138 AA.
AC O97178; A8E6W7; Q56MK8; Q56MK9; Q56ML2; Q56ML4; Q56MM3; Q56MM6; Q56MN5;
AC Q56MP7; Q56MQ1; Q56MQ4; Q56MT0; Q5S4K2;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Enhancer of split malpha protein {ECO:0000303|PubMed:10072784};
DE Short=E(spl)malpha {ECO:0000303|PubMed:10072784};
GN Name=E(spl)malpha-BFM {ECO:0000312|FlyBase:FBgn0002732};
GN Synonyms=malpha {ECO:0000303|PubMed:10072784};
GN ORFNames=CG8337 {ECO:0000312|FlyBase:FBgn0002732};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Embryo;
RX PubMed=10072784; DOI=10.1016/s0925-4773(98)00212-3;
RA Wurmbach E., Wech I., Preiss A.;
RT "The Enhancer of split complex of Drosophila melanogaster harbors three
RT classes of Notch responsive genes.";
RL Mech. Dev. 80:171-180(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC TISSUE=Embryo;
RX PubMed=10603347; DOI=10.1242/dev.127.2.291;
RA Lai E.C., Bodner R., Kavaler J., Freschi G., Posakony J.W.;
RT "Antagonism of Notch signaling activity by members of a novel protein
RT family encoded by the Bearded and Enhancer of split gene complexes.";
RL Development 127:291-306(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41,
RC NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13,
RC NVIII-m15, and NVIII-m19;
RX PubMed=15537803; DOI=10.1093/molbev/msi046;
RA Macdonald S.J., Long A.D.;
RT "Identifying signatures of selection at the enhancer of split neurogenic
RT gene complex in Drosophila.";
RL Mol. Biol. Evol. 22:607-619(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Booth B., Carlson J.W., Frise E., Kapadia B., Park S.,
RA Wan K.H., Yu C., Celniker S.E.;
RL Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 34-138.
RC STRAIN=Nv2001_m0470, Nv2001_m0471, Nv2001_m0472, Nv2001_m0473,
RC Nv2001_m0474, Nv2001_m0475, Nv2001_m0476, Nv2001_m0477, Nv2001_m0478,
RC Nv2001_m0479, Nv2001_m0480, Nv2001_m0481, Nv2001_m0482, Nv2001_m0483,
RC Nv2001_m0484, Nv2001_m0485, Nv2001_m0486, Nv2001_m0488, Nv2001_m0489,
RC Nv2001_m0490, Nv2001_m0491, Nv2001_m0492, Nv2001_m0493, Nv2001_m0494,
RC Nv2001_m0495, Nv2001_m0496, Nv2001_m0498, Nv2001_m0499, Nv2001_m0500,
RC Nv2001_m0501, Nv2001_m0502, Nv2001_m0503, Nv2001_m0504, Nv2001_m0506,
RC Nv2001_m0507, Nv2001_m0508, Nv2001_m0509, Nv2001_m0510, Nv2001_m0511,
RC Nv2001_m0512, Nv2001_m0513, Nv2001_m0514, Nv2001_m0515, Nv2001_m0516,
RC Nv2001_m0517, Nv2001_m0518, Nv2001_m0519, Nv2001_m0520, Nv2001_m0521,
RC Nv2001_m0522, Nv2001_m0523, Nv2001_m0524, Nv2001_m0526, Nv2001_m0527,
RC Nv2001_m0528, Nv2001_m0530, Nv2001_m0531, Nv2001_m0532, Nv2001_m0533,
RC Nv2001_m0534, Nv2001_m0535, Nv2001_m0536, Nv2001_m0537, Nv2001_m0538,
RC Nv2001_m0539, Nv2001_m0540, Nv2001_m0541, Nv2001_m0542, Nv2001_m0543,
RC Nv2001_m0544, Nv2001_m0545, Nv2001_m0546, Nv2001_m0547, Nv2001_m0549,
RC Nv2001_m0550, Nv2001_m0551, Nv2001_m0552, Nv2001_m0553, Nv2001_m0554,
RC Nv2001_m0555, Nv2001_m0556, Nv2001_m0557, Nv2001_m0558, Nv2001_m0559,
RC Nv2001_m0560, Nv2001_m0561, Nv2001_m0562, and Nv2001_m0563;
RX PubMed=16356268; DOI=10.1186/gb-2005-6-12-r105;
RA Macdonald S.J., Pastinen T., Genissel A., Cornforth T.W., Long A.D.;
RT "A low-cost open-source SNP genotyping platform for association mapping
RT applications.";
RL Genome Biol. 6:R105.1-R105.11(2005).
CC -!- FUNCTION: Part of the Notch signaling pathway.
CC -!- DEVELOPMENTAL STAGE: Mesectodermal expression appears shortly before
CC the onset of gastrulation. Later it is detected in the neuro-ectoderm
CC as well as in the mesoderm in a highly dynamic pattern in many stages
CC of embryogenesis. In imaginal disks, expressed as following: in the eye
CC disk, within and posterior to the morphogenetic furrow; in the wing
CC pouch, in the presumptive intervein regions and wing margin; in the leg
CC disk, general expression.
CC -!- SIMILARITY: Belongs to the M4-like protein family. {ECO:0000305}.
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DR EMBL; AJ011140; CAB39164.1; -; Genomic_DNA.
DR EMBL; AF115456; AAF12878.1; -; Genomic_DNA.
DR EMBL; AY779906; AAV59052.1; -; Genomic_DNA.
DR EMBL; AY779907; AAV59064.1; -; Genomic_DNA.
DR EMBL; AY779908; AAV59076.1; -; Genomic_DNA.
DR EMBL; AY779909; AAV59088.1; -; Genomic_DNA.
DR EMBL; AY779910; AAV59100.1; -; Genomic_DNA.
DR EMBL; AY779911; AAV59112.1; -; Genomic_DNA.
DR EMBL; AY779912; AAV59124.1; -; Genomic_DNA.
DR EMBL; AY779913; AAV59136.1; -; Genomic_DNA.
DR EMBL; AY779914; AAV59148.1; -; Genomic_DNA.
DR EMBL; AY779915; AAV59160.1; -; Genomic_DNA.
DR EMBL; AY779916; AAV59172.1; -; Genomic_DNA.
DR EMBL; AY779917; AAV59184.1; -; Genomic_DNA.
DR EMBL; AY779918; AAV59196.1; -; Genomic_DNA.
DR EMBL; AY779919; AAV59208.1; -; Genomic_DNA.
DR EMBL; AY779920; AAV59220.1; -; Genomic_DNA.
DR EMBL; AY779921; AAV59232.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56547.1; -; Genomic_DNA.
DR EMBL; BT030909; ABV82291.1; -; mRNA.
DR EMBL; BT030931; ABV82313.1; -; mRNA.
DR EMBL; BT030967; ABV82349.1; -; mRNA.
DR EMBL; AY905812; AAX60158.1; -; Genomic_DNA.
DR EMBL; AY905813; AAX60159.1; -; Genomic_DNA.
DR EMBL; AY905814; AAX60160.1; -; Genomic_DNA.
DR EMBL; AY905815; AAX60161.1; -; Genomic_DNA.
DR EMBL; AY905816; AAX60162.1; -; Genomic_DNA.
DR EMBL; AY905817; AAX60163.1; -; Genomic_DNA.
DR EMBL; AY905818; AAX60164.1; -; Genomic_DNA.
DR EMBL; AY905819; AAX60165.1; -; Genomic_DNA.
DR EMBL; AY905820; AAX60166.1; -; Genomic_DNA.
DR EMBL; AY905821; AAX60167.1; -; Genomic_DNA.
DR EMBL; AY905822; AAX60168.1; -; Genomic_DNA.
DR EMBL; AY905823; AAX60169.1; -; Genomic_DNA.
DR EMBL; AY905824; AAX60170.1; -; Genomic_DNA.
DR EMBL; AY905825; AAX60171.1; -; Genomic_DNA.
DR EMBL; AY905826; AAX60172.1; -; Genomic_DNA.
DR EMBL; AY905827; AAX60173.1; -; Genomic_DNA.
DR EMBL; AY905828; AAX60174.1; -; Genomic_DNA.
DR EMBL; AY905829; AAX60175.1; -; Genomic_DNA.
DR EMBL; AY905830; AAX60176.1; -; Genomic_DNA.
DR EMBL; AY905831; AAX60177.1; -; Genomic_DNA.
DR EMBL; AY905832; AAX60178.1; -; Genomic_DNA.
DR EMBL; AY905833; AAX60179.1; -; Genomic_DNA.
DR EMBL; AY905834; AAX60180.1; -; Genomic_DNA.
DR EMBL; AY905835; AAX60181.1; -; Genomic_DNA.
DR EMBL; AY905836; AAX60182.1; -; Genomic_DNA.
DR EMBL; AY905837; AAX60183.1; -; Genomic_DNA.
DR EMBL; AY905838; AAX60184.1; -; Genomic_DNA.
DR EMBL; AY905839; AAX60185.1; -; Genomic_DNA.
DR EMBL; AY905840; AAX60186.1; -; Genomic_DNA.
DR EMBL; AY905841; AAX60187.1; -; Genomic_DNA.
DR EMBL; AY905842; AAX60188.1; -; Genomic_DNA.
DR EMBL; AY905843; AAX60189.1; -; Genomic_DNA.
DR EMBL; AY905844; AAX60190.1; -; Genomic_DNA.
DR EMBL; AY905845; AAX60191.1; -; Genomic_DNA.
DR EMBL; AY905846; AAX60192.1; -; Genomic_DNA.
DR EMBL; AY905847; AAX60193.1; -; Genomic_DNA.
DR EMBL; AY905848; AAX60194.1; -; Genomic_DNA.
DR EMBL; AY905849; AAX60195.1; -; Genomic_DNA.
DR EMBL; AY905850; AAX60196.1; -; Genomic_DNA.
DR EMBL; AY905851; AAX60197.1; -; Genomic_DNA.
DR EMBL; AY905852; AAX60198.1; -; Genomic_DNA.
DR EMBL; AY905853; AAX60199.1; -; Genomic_DNA.
DR EMBL; AY905854; AAX60200.1; -; Genomic_DNA.
DR EMBL; AY905855; AAX60201.1; -; Genomic_DNA.
DR EMBL; AY905856; AAX60202.1; -; Genomic_DNA.
DR EMBL; AY905857; AAX60203.1; -; Genomic_DNA.
DR EMBL; AY905858; AAX60204.1; -; Genomic_DNA.
DR EMBL; AY905859; AAX60205.1; -; Genomic_DNA.
DR EMBL; AY905860; AAX60206.1; -; Genomic_DNA.
DR EMBL; AY905861; AAX60207.1; -; Genomic_DNA.
DR EMBL; AY905862; AAX60208.1; -; Genomic_DNA.
DR EMBL; AY905863; AAX60209.1; -; Genomic_DNA.
DR EMBL; AY905864; AAX60210.1; -; Genomic_DNA.
DR EMBL; AY905865; AAX60211.1; -; Genomic_DNA.
DR EMBL; AY905866; AAX60212.1; -; Genomic_DNA.
DR EMBL; AY905867; AAX60213.1; -; Genomic_DNA.
DR EMBL; AY905868; AAX60214.1; -; Genomic_DNA.
DR EMBL; AY905869; AAX60215.1; -; Genomic_DNA.
DR EMBL; AY905870; AAX60216.1; -; Genomic_DNA.
DR EMBL; AY905871; AAX60217.1; -; Genomic_DNA.
DR EMBL; AY905872; AAX60218.1; -; Genomic_DNA.
DR EMBL; AY905873; AAX60219.1; -; Genomic_DNA.
DR EMBL; AY905874; AAX60220.1; -; Genomic_DNA.
DR EMBL; AY905875; AAX60221.1; -; Genomic_DNA.
DR EMBL; AY905876; AAX60222.1; -; Genomic_DNA.
DR EMBL; AY905877; AAX60223.1; -; Genomic_DNA.
DR EMBL; AY905878; AAX60224.1; -; Genomic_DNA.
DR EMBL; AY905879; AAX60225.1; -; Genomic_DNA.
DR EMBL; AY905880; AAX60226.1; -; Genomic_DNA.
DR EMBL; AY905881; AAX60227.1; -; Genomic_DNA.
DR EMBL; AY905882; AAX60228.1; -; Genomic_DNA.
DR EMBL; AY905883; AAX60229.1; -; Genomic_DNA.
DR EMBL; AY905884; AAX60230.1; -; Genomic_DNA.
DR EMBL; AY905885; AAX60231.1; -; Genomic_DNA.
DR EMBL; AY905886; AAX60232.1; -; Genomic_DNA.
DR EMBL; AY905887; AAX60233.1; -; Genomic_DNA.
DR EMBL; AY905888; AAX60234.1; -; Genomic_DNA.
DR EMBL; AY905889; AAX60235.1; -; Genomic_DNA.
DR EMBL; AY905890; AAX60236.1; -; Genomic_DNA.
DR EMBL; AY905891; AAX60237.1; -; Genomic_DNA.
DR EMBL; AY905892; AAX60238.1; -; Genomic_DNA.
DR EMBL; AY905893; AAX60239.1; -; Genomic_DNA.
DR EMBL; AY905894; AAX60240.1; -; Genomic_DNA.
DR EMBL; AY905895; AAX60241.1; -; Genomic_DNA.
DR EMBL; AY905896; AAX60242.1; -; Genomic_DNA.
DR EMBL; AY905897; AAX60243.1; -; Genomic_DNA.
DR EMBL; AY905898; AAX60244.1; -; Genomic_DNA.
DR EMBL; AY905899; AAX60245.1; -; Genomic_DNA.
DR RefSeq; NP_524506.1; NM_079782.3.
DR AlphaFoldDB; O97178; -.
DR BioGRID; 68053; 3.
DR STRING; 7227.FBpp0084330; -.
DR PaxDb; O97178; -.
DR DNASU; 43153; -.
DR EnsemblMetazoa; FBtr0084956; FBpp0084330; FBgn0002732.
DR GeneID; 43153; -.
DR KEGG; dme:Dmel_CG8337; -.
DR CTD; 43153; -.
DR FlyBase; FBgn0002732; E(spl)malpha-BFM.
DR VEuPathDB; VectorBase:FBgn0002732; -.
DR eggNOG; ENOG502T7XI; Eukaryota.
DR GeneTree; ENSGT00900000142304; -.
DR HOGENOM; CLU_1688576_0_0_1; -.
DR InParanoid; O97178; -.
DR OMA; QPAYCYS; -.
DR OrthoDB; 1547394at2759; -.
DR PhylomeDB; O97178; -.
DR BioGRID-ORCS; 43153; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 43153; -.
DR PRO; PR:O97178; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002732; Expressed in mesothoracic segment and 31 other tissues.
DR ExpressionAtlas; O97178; baseline and differential.
DR Genevisible; O97178; DM.
DR GO; GO:0031625; F:ubiquitin protein ligase binding; IPI:FlyBase.
DR GO; GO:0001708; P:cell fate specification; IMP:FlyBase.
DR GO; GO:0045746; P:negative regulation of Notch signaling pathway; IMP:FlyBase.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0007423; P:sensory organ development; IMP:FlyBase.
DR InterPro; IPR029686; Malpha/m4/m2.
DR PANTHER; PTHR12254; PTHR12254; 1.
DR Pfam; PF15952; ESM4; 1.
PE 2: Evidence at transcript level;
KW Notch signaling pathway; Reference proteome.
FT CHAIN 1..138
FT /note="Enhancer of split malpha protein"
FT /id="PRO_0000087061"
SQ SEQUENCE 138 AA; 15876 MW; B277BCC25CD82F59 CRC64;
MCQQVVVVAN TNNKMKTSYS IKQVLKTLFK KQQKQQQKPQ GSLESLESVD NLRNAQVEEA
YYAEIDENAA NEKLAQLAHS QEFEIVEEQE DEEDVYVPVR FARTTAGTFF WTTNLQPVAS
VEPAMCYSMQ FQDRWAQA
