ESMD_DROME
ID ESMD_DROME Reviewed; 173 AA.
AC Q01071; Q01897; Q4V723; Q56MT6; Q56MU1; Q56MU3; Q56MU4; Q56MU6; Q56MU8;
AC Q56MV0; Q56MV5; Q56MV6; Q56MW2; Q56MW7; Q56MW9; Q56MX9; Q56MY0; Q56MY1;
AC Q56N19; Q56N23; Q5S485; Q5S4A9; Q5S4K5;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 187.
DE RecName: Full=Enhancer of split mdelta protein;
DE Short=E(spl)mdelta;
DE AltName: Full=HLH-mdelta;
DE AltName: Full=Split locus enhancer protein mC;
GN Name=E(spl)mdelta-HLH {ECO:0000312|FlyBase:FBgn0002734};
GN Synonyms=HLHmdelta {ECO:0000312|FlyBase:FBgn0002734};
GN ORFNames=CG8328 {ECO:0000312|FlyBase:FBgn0002734};
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND DEVELOPMENTAL STAGE.
RC STRAIN=Oregon-R;
RX PubMed=1427040; DOI=10.1093/genetics/132.2.505;
RA Knust E., Schrons H., Grawe F., Campos-Ortega J.A.;
RT "Seven genes of the Enhancer of split complex of Drosophila melanogaster
RT encode helix-loop-helix proteins.";
RL Genetics 132:505-518(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RC TISSUE=Embryo;
RX PubMed=1528887; DOI=10.1073/pnas.89.18.8731;
RA Delidakis C., Artavanis-Tsakonas S.;
RT "The Enhancer of split [E(spl)] locus of Drosophila encodes seven
RT independent helix-loop-helix proteins.";
RL Proc. Natl. Acad. Sci. U.S.A. 89:8731-8735(1992).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=NVIII-1, NVIII-18, NVIII-2, NVIII-22, NVIII-24, NVIII-28, NVIII-41,
RC NVIII-42, NVIII-46, NVIII-5, NVIII-9, NVIII-m11, NVIII-m12, NVIII-m13,
RC NVIII-m15, and NVIII-m19;
RX PubMed=15537803; DOI=10.1093/molbev/msi046;
RA Macdonald S.J., Long A.D.;
RT "Identifying signatures of selection at the enhancer of split neurogenic
RT gene complex in Drosophila.";
RL Mol. Biol. Evol. 22:607-619(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 64-173.
RC STRAIN=Nv2001_m0376, Nv2001_m0377, Nv2001_m0378, Nv2001_m0379,
RC Nv2001_m0380, Nv2001_m0381, Nv2001_m0382, Nv2001_m0383, Nv2001_m0384,
RC Nv2001_m0385, Nv2001_m0386, Nv2001_m0387, Nv2001_m0388, Nv2001_m0389,
RC Nv2001_m0390, Nv2001_m0391, Nv2001_m0392, Nv2001_m0393, Nv2001_m0394,
RC Nv2001_m0395, Nv2001_m0396, Nv2001_m0397, Nv2001_m0398, Nv2001_m0399,
RC Nv2001_m0400, Nv2001_m0401, Nv2001_m0402, Nv2001_m0403, Nv2001_m0404,
RC Nv2001_m0405, Nv2001_m0406, Nv2001_m0407, Nv2001_m0408, Nv2001_m0409,
RC Nv2001_m0410, Nv2001_m0411, Nv2001_m0412, Nv2001_m0413, Nv2001_m0414,
RC Nv2001_m0415, Nv2001_m0416, Nv2001_m0417, Nv2001_m0418, Nv2001_m0419,
RC Nv2001_m0420, Nv2001_m0421, Nv2001_m0422, Nv2001_m0423, Nv2001_m0424,
RC Nv2001_m0425, Nv2001_m0426, Nv2001_m0427, Nv2001_m0428, Nv2001_m0429,
RC Nv2001_m0430, Nv2001_m0431, Nv2001_m0432, Nv2001_m0433, Nv2001_m0434,
RC Nv2001_m0435, Nv2001_m0436, Nv2001_m0437, Nv2001_m0438, Nv2001_m0439,
RC Nv2001_m0440, Nv2001_m0441, Nv2001_m0442, Nv2001_m0443, Nv2001_m0444,
RC Nv2001_m0445, Nv2001_m0446, Nv2001_m0447, Nv2001_m0448, Nv2001_m0449,
RC Nv2001_m0450, Nv2001_m0451, Nv2001_m0452, Nv2001_m0453, Nv2001_m0454,
RC Nv2001_m0455, Nv2001_m0456, Nv2001_m0457, Nv2001_m0458, Nv2001_m0459,
RC Nv2001_m0460, Nv2001_m0462, Nv2001_m0463, Nv2001_m0464, Nv2001_m0465,
RC Nv2001_m0466, Nv2001_m0467, Nv2001_m0468, and Nv2001_m0469;
RX PubMed=16356268; DOI=10.1186/gb-2005-6-12-r105;
RA Macdonald S.J., Pastinen T., Genissel A., Cornforth T.W., Long A.D.;
RT "A low-cost open-source SNP genotyping platform for association mapping
RT applications.";
RL Genome Biol. 6:R105.1-R105.11(2005).
RN [8]
RP DOMAIN WRPW MOTIF.
RX PubMed=8001118; DOI=10.1016/0092-8674(94)90070-1;
RA Paroush Z., Finley R.L. Jr., Kidd T., Wainwright S.M., Ingham P.W.,
RA Brent R., Ish-Horowicz D.;
RT "Groucho is required for Drosophila neurogenesis, segmentation, and sex
RT determination and interacts directly with hairy-related bHLH proteins.";
RL Cell 79:805-815(1994).
RN [9]
RP FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=28899667; DOI=10.1016/j.ydbio.2017.09.011;
RA Li X., Chen R., Zhu S.;
RT "bHLH-O proteins balance the self-renewal and differentiation of Drosophila
RT neural stem cells by regulating Earmuff expression.";
RL Dev. Biol. 431:239-251(2017).
CC -!- FUNCTION: Transcriptional repressor of genes that require a bHLH
CC protein for their transcription (By similarity). May serve as a
CC transcriptional regulator of the Achaete-scute complex (AS-C) genes
CC (PubMed:1528887). Contributes to the neural-epidermal lineage decision
CC during early neurogenesis (PubMed:1427040). As part of the Notch
CC signaling pathway, required to maintain the self-renewal and identity
CC of type II neuroblasts by regulating the expression of the
CC transcriptional repressor erm (PubMed:28899667).
CC {ECO:0000250|UniProtKB:P14003, ECO:0000269|PubMed:1427040,
CC ECO:0000269|PubMed:1528887, ECO:0000269|PubMed:28899667}.
CC -!- SUBUNIT: Transcription repression requires formation of a complex with
CC a corepressor protein (Groucho). {ECO:0000250|UniProtKB:P14003,
CC ECO:0000250|UniProtKB:Q26263}.
CC -!- INTERACTION:
CC Q01071; Q24276: Cdc37; NbExp=3; IntAct=EBI-118907, EBI-167469;
CC Q01071; P16371: gro; NbExp=4; IntAct=EBI-118907, EBI-153866;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DEVELOPMENTAL STAGE: In embryo, expressed during the initial stages of
CC germ band exclusively within the neuroectoderm, both in the territory
CC of the trunk and in cephalic regions. During stage 9, expressed within
CC the procephalic lobe and the ventral ectoderm.
CC {ECO:0000269|PubMed:1427040}.
CC -!- DOMAIN: Has a particular type of basic domain (presence of a helix-
CC interrupting proline) that binds to the N-box (CACNAG), rather than the
CC canonical E-box (CANNTG). {ECO:0000269|PubMed:8001118}.
CC -!- DOMAIN: The C-terminal WRPW motif is a transcriptional repression
CC domain necessary for the interaction with Groucho, a transcriptional
CC corepressor recruited to specific target DNA by Hairy-related proteins.
CC {ECO:0000269|PubMed:8001118}.
CC -!- DISRUPTION PHENOTYPE: RNAi-mediated knockdown of the protein in the
CC type II neuroblasts lineage results in an increase in the number of
CC type II neuroblasts. Simultaneous RNAi-mediated knockdown of the ETS
CC protein pnt restores normal neuroblast numbers.
CC {ECO:0000269|PubMed:28899667}.
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DR EMBL; X67048; CAA47433.1; -; mRNA.
DR EMBL; M96168; AAA28911.1; -; Genomic_DNA.
DR EMBL; AY779906; AAV59045.1; -; Genomic_DNA.
DR EMBL; AY779907; AAV59057.1; -; Genomic_DNA.
DR EMBL; AY779908; AAV59069.1; -; Genomic_DNA.
DR EMBL; AY779909; AAV59081.1; -; Genomic_DNA.
DR EMBL; AY779910; AAV59093.1; -; Genomic_DNA.
DR EMBL; AY779911; AAV59105.1; -; Genomic_DNA.
DR EMBL; AY779912; AAV59117.1; -; Genomic_DNA.
DR EMBL; AY779913; AAV59129.1; -; Genomic_DNA.
DR EMBL; AY779914; AAV59141.1; -; Genomic_DNA.
DR EMBL; AY779915; AAV59153.1; -; Genomic_DNA.
DR EMBL; AY779916; AAV59165.1; -; Genomic_DNA.
DR EMBL; AY779917; AAV59177.1; -; Genomic_DNA.
DR EMBL; AY779918; AAV59189.1; -; Genomic_DNA.
DR EMBL; AY779919; AAV59201.1; -; Genomic_DNA.
DR EMBL; AY779920; AAV59213.1; -; Genomic_DNA.
DR EMBL; AY779921; AAV59225.1; -; Genomic_DNA.
DR EMBL; AE014297; AAF56544.1; -; Genomic_DNA.
DR EMBL; BT022133; AAY51528.2; -; mRNA.
DR EMBL; AY905719; AAX60065.1; -; Genomic_DNA.
DR EMBL; AY905720; AAX60066.1; -; Genomic_DNA.
DR EMBL; AY905721; AAX60067.1; -; Genomic_DNA.
DR EMBL; AY905722; AAX60068.1; -; Genomic_DNA.
DR EMBL; AY905723; AAX60069.1; -; Genomic_DNA.
DR EMBL; AY905724; AAX60070.1; -; Genomic_DNA.
DR EMBL; AY905725; AAX60071.1; -; Genomic_DNA.
DR EMBL; AY905726; AAX60072.1; -; Genomic_DNA.
DR EMBL; AY905727; AAX60073.1; -; Genomic_DNA.
DR EMBL; AY905728; AAX60074.1; -; Genomic_DNA.
DR EMBL; AY905729; AAX60075.1; -; Genomic_DNA.
DR EMBL; AY905730; AAX60076.1; -; Genomic_DNA.
DR EMBL; AY905731; AAX60077.1; -; Genomic_DNA.
DR EMBL; AY905732; AAX60078.1; -; Genomic_DNA.
DR EMBL; AY905733; AAX60079.1; -; Genomic_DNA.
DR EMBL; AY905734; AAX60080.1; -; Genomic_DNA.
DR EMBL; AY905735; AAX60081.1; -; Genomic_DNA.
DR EMBL; AY905736; AAX60082.1; -; Genomic_DNA.
DR EMBL; AY905737; AAX60083.1; -; Genomic_DNA.
DR EMBL; AY905738; AAX60084.1; -; Genomic_DNA.
DR EMBL; AY905739; AAX60085.1; -; Genomic_DNA.
DR EMBL; AY905740; AAX60086.1; -; Genomic_DNA.
DR EMBL; AY905741; AAX60087.1; -; Genomic_DNA.
DR EMBL; AY905742; AAX60088.1; -; Genomic_DNA.
DR EMBL; AY905743; AAX60089.1; -; Genomic_DNA.
DR EMBL; AY905744; AAX60090.1; -; Genomic_DNA.
DR EMBL; AY905745; AAX60091.1; -; Genomic_DNA.
DR EMBL; AY905746; AAX60092.1; -; Genomic_DNA.
DR EMBL; AY905747; AAX60093.1; -; Genomic_DNA.
DR EMBL; AY905748; AAX60094.1; -; Genomic_DNA.
DR EMBL; AY905749; AAX60095.1; -; Genomic_DNA.
DR EMBL; AY905750; AAX60096.1; -; Genomic_DNA.
DR EMBL; AY905751; AAX60097.1; -; Genomic_DNA.
DR EMBL; AY905752; AAX60098.1; -; Genomic_DNA.
DR EMBL; AY905753; AAX60099.1; -; Genomic_DNA.
DR EMBL; AY905754; AAX60100.1; -; Genomic_DNA.
DR EMBL; AY905755; AAX60101.1; -; Genomic_DNA.
DR EMBL; AY905756; AAX60102.1; -; Genomic_DNA.
DR EMBL; AY905757; AAX60103.1; -; Genomic_DNA.
DR EMBL; AY905758; AAX60104.1; -; Genomic_DNA.
DR EMBL; AY905759; AAX60105.1; -; Genomic_DNA.
DR EMBL; AY905760; AAX60106.1; -; Genomic_DNA.
DR EMBL; AY905761; AAX60107.1; -; Genomic_DNA.
DR EMBL; AY905762; AAX60108.1; -; Genomic_DNA.
DR EMBL; AY905763; AAX60109.1; -; Genomic_DNA.
DR EMBL; AY905764; AAX60110.1; -; Genomic_DNA.
DR EMBL; AY905765; AAX60111.1; -; Genomic_DNA.
DR EMBL; AY905766; AAX60112.1; -; Genomic_DNA.
DR EMBL; AY905767; AAX60113.1; -; Genomic_DNA.
DR EMBL; AY905768; AAX60114.1; -; Genomic_DNA.
DR EMBL; AY905769; AAX60115.1; -; Genomic_DNA.
DR EMBL; AY905770; AAX60116.1; -; Genomic_DNA.
DR EMBL; AY905771; AAX60117.1; -; Genomic_DNA.
DR EMBL; AY905772; AAX60118.1; -; Genomic_DNA.
DR EMBL; AY905773; AAX60119.1; -; Genomic_DNA.
DR EMBL; AY905774; AAX60120.1; -; Genomic_DNA.
DR EMBL; AY905775; AAX60121.1; -; Genomic_DNA.
DR EMBL; AY905776; AAX60122.1; -; Genomic_DNA.
DR EMBL; AY905777; AAX60123.1; -; Genomic_DNA.
DR EMBL; AY905778; AAX60124.1; -; Genomic_DNA.
DR EMBL; AY905779; AAX60125.1; -; Genomic_DNA.
DR EMBL; AY905780; AAX60126.1; -; Genomic_DNA.
DR EMBL; AY905781; AAX60127.1; -; Genomic_DNA.
DR EMBL; AY905782; AAX60128.1; -; Genomic_DNA.
DR EMBL; AY905783; AAX60129.1; -; Genomic_DNA.
DR EMBL; AY905784; AAX60130.1; -; Genomic_DNA.
DR EMBL; AY905785; AAX60131.1; -; Genomic_DNA.
DR EMBL; AY905786; AAX60132.1; -; Genomic_DNA.
DR EMBL; AY905787; AAX60133.1; -; Genomic_DNA.
DR EMBL; AY905788; AAX60134.1; -; Genomic_DNA.
DR EMBL; AY905789; AAX60135.1; -; Genomic_DNA.
DR EMBL; AY905790; AAX60136.1; -; Genomic_DNA.
DR EMBL; AY905791; AAX60137.1; -; Genomic_DNA.
DR EMBL; AY905792; AAX60138.1; -; Genomic_DNA.
DR EMBL; AY905793; AAX60139.1; -; Genomic_DNA.
DR EMBL; AY905794; AAX60140.1; -; Genomic_DNA.
DR EMBL; AY905795; AAX60141.1; -; Genomic_DNA.
DR EMBL; AY905796; AAX60142.1; -; Genomic_DNA.
DR EMBL; AY905797; AAX60143.1; -; Genomic_DNA.
DR EMBL; AY905798; AAX60144.1; -; Genomic_DNA.
DR EMBL; AY905799; AAX60145.1; -; Genomic_DNA.
DR EMBL; AY905800; AAX60146.1; -; Genomic_DNA.
DR EMBL; AY905801; AAX60147.1; -; Genomic_DNA.
DR EMBL; AY905802; AAX60148.1; -; Genomic_DNA.
DR EMBL; AY905803; AAX60149.1; -; Genomic_DNA.
DR EMBL; AY905804; AAX60150.1; -; Genomic_DNA.
DR EMBL; AY905805; AAX60151.1; -; Genomic_DNA.
DR EMBL; AY905806; AAX60152.1; -; Genomic_DNA.
DR EMBL; AY905807; AAX60153.1; -; Genomic_DNA.
DR EMBL; AY905808; AAX60154.1; -; Genomic_DNA.
DR EMBL; AY905809; AAX60155.1; -; Genomic_DNA.
DR EMBL; AY905810; AAX60156.1; -; Genomic_DNA.
DR EMBL; AY905811; AAX60157.1; -; Genomic_DNA.
DR PIR; A46177; A46177.
DR RefSeq; NP_524503.2; NM_079779.3.
DR AlphaFoldDB; Q01071; -.
DR SMR; Q01071; -.
DR BioGRID; 68050; 30.
DR DIP; DIP-722N; -.
DR ELM; Q01071; -.
DR IntAct; Q01071; 28.
DR STRING; 7227.FBpp0084328; -.
DR PaxDb; Q01071; -.
DR EnsemblMetazoa; FBtr0084954; FBpp0084328; FBgn0002734.
DR GeneID; 43150; -.
DR KEGG; dme:Dmel_CG8328; -.
DR CTD; 43150; -.
DR FlyBase; FBgn0002734; E(spl)mdelta-HLH.
DR VEuPathDB; VectorBase:FBgn0002734; -.
DR eggNOG; KOG4304; Eukaryota.
DR GeneTree; ENSGT00940000167178; -.
DR HOGENOM; CLU_068550_2_2_1; -.
DR InParanoid; Q01071; -.
DR OMA; CHVAGRQ; -.
DR OrthoDB; 1378299at2759; -.
DR PhylomeDB; Q01071; -.
DR SignaLink; Q01071; -.
DR BioGRID-ORCS; 43150; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 43150; -.
DR PRO; PR:Q01071; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0002734; Expressed in eye disc (Drosophila) and 34 other tissues.
DR Genevisible; Q01071; DM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:UniProtKB.
DR GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:FlyBase.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:UniProtKB-KW.
DR GO; GO:0048052; P:R1/R6 cell differentiation; IMP:FlyBase.
DR GO; GO:0045466; P:R7 cell differentiation; IMP:FlyBase.
DR GO; GO:1902692; P:regulation of neuroblast proliferation; IMP:UniProtKB.
DR GO; GO:0050767; P:regulation of neurogenesis; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0007525; P:somatic muscle development; IMP:FlyBase.
DR Gene3D; 4.10.280.10; -; 1.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR003650; Orange_dom.
DR Pfam; PF07527; Hairy_orange; 1.
DR Pfam; PF00010; HLH; 1.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00511; ORANGE; 1.
DR SUPFAM; SSF47459; SSF47459; 1.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS51054; ORANGE; 1.
PE 1: Evidence at protein level;
KW Developmental protein; Differentiation; DNA-binding; Neurogenesis;
KW Notch signaling pathway; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..173
FT /note="Enhancer of split mdelta protein"
FT /id="PRO_0000127178"
FT DOMAIN 15..72
FT /note="bHLH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00981"
FT DOMAIN 93..126
FT /note="Orange"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00380"
FT REGION 147..173
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 170..173
FT /note="WRPW motif"
FT VARIANT 121
FT /note="H -> R (in strain: NVIII-42 and NVIII-18)"
FT VARIANT 162
FT /note="D -> V (in strain: NVIII-m11)"
FT CONFLICT 82
FT /note="S -> W (in Ref. 2; CAA47433)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 173 AA; 20195 MW; F44DA6100CE0874F CRC64;
MAVQGQRFMT KTQHYRKVTK PLLERKRRAR MNLYLDELKD LIVDTMDAQG EQVSKLEKAD
ILELTVNYLK AQQQQRVANP QSPPPDQVNL DKFRAGYTQA AYEVSHIFST VPGLDLKFGT
HLMKQLGHQL KDMKQEEEII DMAEEPVNLA DQKRSKSPRE EDIHHGEEVW RPW
