ESN_DROME
ID ESN_DROME Reviewed; 785 AA.
AC Q9U1I1; A8E6H1; Q8SX20; Q9V4H9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Protein espinas;
GN Name=esn; ORFNames=CG43722;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:CAB64381.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=DP CN BW; TISSUE=Embryo {ECO:0000269|PubMed:10485852};
RX PubMed=10485852; DOI=10.1101/gad.13.17.2315;
RA Gubb D., Green C., Huen D., Coulson D., Johnson G., Tree D.R.P.,
RA Collier S., Roote J.;
RT "The balance between isoforms of the prickle LIM domain protein is critical
RT for planar polarity in Drosophila imaginal discs.";
RL Genes Dev. 13:2315-2327(1999).
RN [2] {ECO:0000312|EMBL:AAF59292.2}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley {ECO:0000269|PubMed:10731132};
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3] {ECO:0000305, ECO:0000312|EMBL:AAF59292.2}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4] {ECO:0000312|EMBL:AAM11251.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAM11251.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Stapleton M., Carlson J.W., Frise E., Kapadia B., Park S., Wan K.H., Yu C.,
RA Celniker S.E.;
RL Submitted (OCT-2007) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAM11251.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ251892; CAB64381.1; -; mRNA.
DR EMBL; AE013599; AAF59292.2; -; Genomic_DNA.
DR EMBL; AY094898; AAM11251.1; ALT_FRAME; mRNA.
DR EMBL; BT030763; ABV82145.1; -; mRNA.
DR RefSeq; NP_524990.1; NM_080251.4.
DR RefSeq; NP_724533.1; NM_165507.2.
DR AlphaFoldDB; Q9U1I1; -.
DR SMR; Q9U1I1; -.
DR BioGRID; 72789; 35.
DR STRING; 7227.FBpp0302896; -.
DR PaxDb; Q9U1I1; -.
DR DNASU; 53557; -.
DR EnsemblMetazoa; FBtr0329856; FBpp0302894; FBgn0263934.
DR EnsemblMetazoa; FBtr0329857; FBpp0302895; FBgn0263934.
DR GeneID; 53557; -.
DR KEGG; dme:Dmel_CG43722; -.
DR UCSC; CG12833-RA; d. melanogaster.
DR CTD; 53557; -.
DR FlyBase; FBgn0263934; esn.
DR VEuPathDB; VectorBase:FBgn0263934; -.
DR eggNOG; KOG1704; Eukaryota.
DR GeneTree; ENSGT00940000153629; -.
DR HOGENOM; CLU_008937_4_0_1; -.
DR InParanoid; Q9U1I1; -.
DR OMA; CKGCEES; -.
DR OrthoDB; 113951at2759; -.
DR PhylomeDB; Q9U1I1; -.
DR Reactome; R-DME-4608870; Asymmetric localization of PCP proteins.
DR BioGRID-ORCS; 53557; 0 hits in 3 CRISPR screens.
DR ChiTaRS; esn; fly.
DR GenomeRNAi; 53557; -.
DR PRO; PR:Q9U1I1; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0263934; Expressed in wing disc and 30 other tissues.
DR ExpressionAtlas; Q9U1I1; baseline and differential.
DR Genevisible; Q9U1I1; DM.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0070593; P:dendrite self-avoidance; IMP:FlyBase.
DR CDD; cd09415; LIM1_Prickle; 1.
DR CDD; cd09418; LIM2_Prickle; 1.
DR CDD; cd09420; LIM3_Prickle; 1.
DR CDD; cd09827; PET_Prickle; 1.
DR InterPro; IPR033725; LIM1_prickle.
DR InterPro; IPR033726; LIM2_prickle.
DR InterPro; IPR033727; LIM3_prickle.
DR InterPro; IPR010442; PET_domain.
DR InterPro; IPR033723; PET_prickle.
DR InterPro; IPR001781; Znf_LIM.
DR Pfam; PF00412; LIM; 2.
DR Pfam; PF06297; PET; 1.
DR SMART; SM00132; LIM; 3.
DR PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR PROSITE; PS51303; PET; 1.
PE 2: Evidence at transcript level;
KW LIM domain; Metal-binding; Reference proteome; Repeat; Zinc.
FT CHAIN 1..785
FT /note="Protein espinas"
FT /id="PRO_0000288827"
FT DOMAIN 135..243
FT /note="PET"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT DOMAIN 242..306
FT /note="LIM zinc-binding 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 307..367
FT /note="LIM zinc-binding 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT DOMAIN 368..430
FT /note="LIM zinc-binding 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT REGION 1..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 125..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 427..484
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 638..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 35..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 428..456
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 457..473
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 86608 MW; 5EF4029A593EA70E CRC64;
MQQAPQQQQH PHPPSSSYYT QTESELLQIE AGGTGLTFAS HSQRPESAIS QVASTAHLDV
PSAASSGSGG SAVSGGSGGA PESAGRFVSP LQRRHCQPPS HLPLNSVASP LRTASYKSAA
AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY
VNSPGEKYRV KQLLHQLPPQ DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD
ERPCKGCEEP LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH
HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM REGKPYCLAC
FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC TCRCSLLGRP FLPRRGTIYC
SIACSKGEPP TPSDTSSGPQ LRPTHRASTS SQIAKSPRRG GERERDPGRK AHHGHPKATG
SAGDLLERQE RQRMEAAGVA DLLLGGGVPG MPRPAHPPPI DLTELGISLD NICAGDKSIF
GDTQTLTNSM PDMLLSKADD SHSYQSIDKI NLNSPSNSDL TQSTQELANE LELDNEPVRE
LPHDGYEQLF ANNRNQEHPA EQYDDEQLDN RPMKEVRFHS VQDTMSRSKS YTDNSNARRR
RRRRNQSRSS SEMQINQTNL RLHNAQTQVG TTPLNLLNNL DNCDVASICS TCSSSSSSDM
DDYVYRLPAR KHYGGVRVAY VPNDALAYER KKKMAQDSSL APGAGNASVG GAPAIMHESK
NCTIS
