ID   ESN_DROPS               Reviewed;         795 AA.
AC   Q292U5;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Protein espinas;
GN   Name=esn {ECO:0000250|UniProtKB:Q9U1I1}; ORFNames=GA11840;
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245;
RN   [1] {ECO:0000312|EMBL:EAL24766.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94;
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P., Couronne O.,
RA   Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J., van Batenburg M.F.,
RA   Howells S.L., Scherer S.E., Sodergren E., Matthews B.B., Crosby M.A.,
RA   Schroeder A.J., Ortiz-Barrientos D., Rives C.M., Metzker M.L., Muzny D.M.,
RA   Scott G., Steffen D., Wheeler D.A., Worley K.C., Havlak P., Durbin K.J.,
RA   Egan A., Gill R., Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y.,
RA   Waldron L., Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.F.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.M.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura: chromosomal,
RT   gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
CC   -!- SIMILARITY: Belongs to the prickle / espinas / testin family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=EAL24766.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; CM000071; EAL24766.1; ALT_SEQ; Genomic_DNA.
DR   AlphaFoldDB; Q292U5; -.
DR   SMR; Q292U5; -.
DR   STRING; 7237.FBpp0277331; -.
DR   eggNOG; KOG1704; Eukaryota.
DR   HOGENOM; CLU_008937_4_0_1; -.
DR   InParanoid; Q292U5; -.
DR   OMA; CKGCEES; -.
DR   PhylomeDB; Q292U5; -.
DR   ChiTaRS; esn; fly.
DR   Proteomes; UP000001819; Genome assembly.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd09415; LIM1_Prickle; 1.
DR   CDD; cd09418; LIM2_Prickle; 1.
DR   CDD; cd09420; LIM3_Prickle; 1.
DR   CDD; cd09827; PET_Prickle; 1.
DR   InterPro; IPR033725; LIM1_prickle.
DR   InterPro; IPR033726; LIM2_prickle.
DR   InterPro; IPR033727; LIM3_prickle.
DR   InterPro; IPR010442; PET_domain.
DR   InterPro; IPR033723; PET_prickle.
DR   InterPro; IPR001781; Znf_LIM.
DR   Pfam; PF00412; LIM; 2.
DR   Pfam; PF06297; PET; 1.
DR   SMART; SM00132; LIM; 3.
DR   PROSITE; PS00478; LIM_DOMAIN_1; 2.
DR   PROSITE; PS50023; LIM_DOMAIN_2; 3.
DR   PROSITE; PS51303; PET; 1.
PE   3: Inferred from homology;
KW   LIM domain; Metal-binding; Reference proteome; Repeat; Zinc.
FT   CHAIN           1..795
FT                   /note="Protein espinas"
FT                   /id="PRO_0000288828"
FT   DOMAIN          135..243
FT                   /note="PET"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00636"
FT   DOMAIN          242..306
FT                   /note="LIM zinc-binding 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          307..367
FT                   /note="LIM zinc-binding 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   DOMAIN          368..430
FT                   /note="LIM zinc-binding 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00125"
FT   REGION          30..96
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          427..487
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          616..684
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..91
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        428..456
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        457..475
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        620..651
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   795 AA;  87704 MW;  25D2F72D3E6C595E CRC64;
     MQQQPQPQPL PHSSYYTQTE SELLQIEAGG TGLTFPPHRS EMAATSSQLQ QASMSSNVAS
     TATSSNLDVP SGGSTGSGSG GQTTSHFVSP LQRRHCQPPS HLPLNSVASP LRTASYKTAA
     AVAGHGFHHS HHQQLDFQRN SQSDDDSGCA LEEYTWVPPG LRPDQVRLYF SQLPDDKVPY
     VNSPGEKYRV KQLLHQLPPQ DNEVRYCHSL SDEERKELRI FSAQRKREAL GRGAVRLLSD
     ERPCKGCEES LSGGDIVVFA QRLGAQLCWH PGCFVCSVCK ELLVDLIYFQ RDGNLYCGRH
     HAETQKPRCS ACDEIIFSDE CTEAEGRTWH MKHFACQECE HQLGGQRYIM REGKPYCLGC
     FDTMFAEYCD YCGEVIGVDQ GQMSHDGQHW HATDQCFSCC TCRCSLLGRP FLPRRGTIYC
     SIACSKGEPP TPSDTSSGPQ LRPTHRASTS SQIARSPRRS GDRDRERESS RKANHGHGPV
     KGTGSAGDLL ERQERKRMEA AGVADLLLGG GVPGMPRPAH PPPIDLTELG ISLDNICAGD
     KSIFGDSQLT SSMPDMLLSK AEDSHSYQSI DKINLNSPSN SDLTQSTQEL ANELELDNDP
     VRELPHDGYE QLFANNRNTK KGHELQDMQG EEDGEQLDNR PLKEVRFHSV QDTMSRSKSY
     TDNSNARRRR RRRNQSRSSS EMQINQTNLR LHNAQTQAGT GTGAHNLLNN LDNCDVASIC
     STCSSSSSSD MDDYVYRLPA RKHYGGVRVA YVPNDALAYE RKKKLAQDPS LAAAASAAVP
     GVPGVMNESK NCTIS