ID   ESP22_MOUSE             Reviewed;         111 AA.
AC   A8R0V4;
DT   11-DEC-2013, integrated into UniProtKB/Swiss-Prot.
DT   15-JAN-2008, sequence version 1.
DT   03-AUG-2022, entry version 31.
DE   RecName: Full=Exocrine gland-secreted peptide 22;
DE   Flags: Precursor;
GN   Name=Esp22 {ECO:0000312|EMBL:BAF92737.1};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1] {ECO:0000312|EMBL:BAF92737.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000312|EMBL:BAF92737.1};
RX   PubMed=17935991; DOI=10.1016/j.cub.2007.09.042;
RA   Kimoto H., Sato K., Nodari F., Haga S., Holy T.E., Touhara K.;
RT   "Sex- and strain-specific expression and vomeronasal activity of mouse ESP
RT   family peptides.";
RL   Curr. Biol. 17:1879-1884(2007).
RN   [2] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J {ECO:0000269|PubMed:19468303};
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3] {ECO:0000305}
RP   FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE,
RP   POLYMORPHISM, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX   PubMed=24089208; DOI=10.1038/nature12579;
RA   Ferrero D.M., Moeller L.M., Osakada T., Horio N., Li Q., Roy D.S.,
RA   Cichy A., Spehr M., Touhara K., Liberles S.D.;
RT   "A juvenile mouse pheromone inhibits sexual behaviour through the
RT   vomeronasal system.";
RL   Nature 502:368-371(2013).
CC   -!- FUNCTION: Pheromone produced by juveniles which activates a small
CC       number of vomeronasal organ sensory neurons and exhibits a powerful
CC       inhibitory effect on adult male mating behavior.
CC       {ECO:0000269|PubMed:24089208}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:24089208}.
CC       Note=Secreted from the lacrimal gland into tears.
CC       {ECO:0000269|PubMed:24089208}.
CC   -!- TISSUE SPECIFICITY: Expressed in acinar cells of the lacrimal gland
CC       from where it is secreted into tears. Not detected in a range of other
CC       tissues tested including other exocrine glands, internal organs and
CC       sensory epithelia. {ECO:0000269|PubMed:24089208}.
CC   -!- DEVELOPMENTAL STAGE: Expressed maximally between 2 and 3 weeks of age.
CC       Levels decrease sharply after 4 weeks around puberty. Expression is 50-
CC       fold higher in juveniles than adults with similar levels in male and
CC       female juveniles. Not expressed in castrated or ovariectomized adults.
CC       {ECO:0000269|PubMed:24089208}.
CC   -!- POLYMORPHISM: Highly expressed in juveniles of strains BALB/C and
CC       C56BL/5 but expression is not detected in juveniles of strains CBA or
CC       C3H/He. {ECO:0000269|PubMed:24089208}.
CC   -!- SIMILARITY: Belongs to the exocrine gland-secreted peptide family.
CC       {ECO:0000305}.
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DR   EMBL; AB307001; BAF92737.1; -; Genomic_DNA.
DR   EMBL; AC127274; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; A8R0V4; -.
DR   PRIDE; A8R0V4; -.
DR   Ensembl; ENSMUST00000233133; ENSMUSP00000156441; ENSMUSG00000117311.
DR   MGI; MGI:5510833; Esp22.
DR   VEuPathDB; HostDB:ENSMUSG00000117311; -.
DR   GeneTree; ENSGT01030000239647; -.
DR   PRO; PR:A8R0V4; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; A8R0V4; protein.
DR   Bgee; ENSMUSG00000117311; Expressed in digestive system element and 5 other tissues.
DR   GO; GO:0005615; C:extracellular space; IDA:UniProtKB.
DR   GO; GO:0005186; F:pheromone activity; IDA:UniProtKB.
DR   GO; GO:0007610; P:behavior; IEA:UniProtKB-KW.
DR   GO; GO:1902436; P:negative regulation of male mating behavior; IDA:UniProtKB.
DR   InterPro; IPR032253; Esp1/Esp22.
DR   Pfam; PF16590; ESP; 1.
PE   1: Evidence at protein level;
KW   Behavior; Pheromone; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   CHAIN           25..111
FT                   /note="Exocrine gland-secreted peptide 22"
FT                   /id="PRO_0000424701"
SQ   SEQUENCE   111 AA;  12570 MW;  0FA5507211AAEEF9 CRC64;
     MNSVPVMLFS ISILLAAMLT EGRGLTQTQK ESIFSAEHKS DLKSYLEMLV CRRLRDVPES
     VIHISKVSKE ILPDDLLSTY LLELLVCFDK DKLVQSKGIV FNTIKRLLTN T