ID   ESPA_MYCTO              Reviewed;         392 AA.
AC   P9WJE0; L0TDB5; O06267; Q7D572;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=ESX-1 secretion-associated protein EspA {ECO:0000250|UniProtKB:P9WJE1};
GN   Name=espA {ECO:0000250|UniProtKB:P9WJE1}; OrderedLocusNames=MT3718;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for secretion of EsxA (ESAT-6) and EsxB (CFP-10) and
CC       for virulence. {ECO:0000250|UniProtKB:P9WJE1}.
CC   -!- SUBUNIT: Homodimer; disulfide-linked. {ECO:0000250|UniProtKB:P9WJE1}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WJE1}.
CC       Note=Secreted via the ESX-1 / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WJE1}.
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DR   EMBL; AE000516; AAK48077.1; -; Genomic_DNA.
DR   PIR; A70957; A70957.
DR   RefSeq; WP_003419551.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJE0; -.
DR   EnsemblBacteria; AAK48077; AAK48077; MT3718.
DR   GeneID; 45427602; -.
DR   KEGG; mtc:MT3718; -.
DR   PATRIC; fig|83331.31.peg.4002; -.
DR   HOGENOM; CLU_795740_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   InterPro; IPR043796; ESX-1_EspA/EspE-like.
DR   Pfam; PF18879; EspA_EspE; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; Secreted; Virulence.
FT   CHAIN           1..392
FT                   /note="ESX-1 secretion-associated protein EspA"
FT                   /id="PRO_0000427846"
FT   REGION          302..392
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        138
FT                   /note="Interchain"
FT                   /evidence="ECO:0000250|UniProtKB:P9WJE1"
SQ   SEQUENCE   392 AA;  39900 MW;  B762BE3B7C0FEC7D CRC64;
     MSRAFIIDPT ISAIDGLYDL LGIGIPNQGG ILYSSLEYFE KALEELAAAF PGDGWLGSAA
     DKYAGKNRNH VNFFQELADL DRQLISLIHD QANAVQTTRD ILEGAKKGLE FVRPVAVDLT
     YIPVVGHALS AAFQAPFCAG AMAVVGGALA YLVVKTLINA TQLLKLLAKL AELVAAAIAD
     IISDVADIIK GILGEVWEFI TNALNGLKEL WDKLTGWVTG LFSRGWSNLE SFFAGVPGLT
     GATSGLSQVT GLFGAAGLSA SSGLAHADSL ASSASLPALA GIGGGSGFGG LPSLAQVHAA
     STRQALRPRA DGPVGAAAEQ VGGQSQLVSA QGSQGMGGPV GMGGMHPSSG ASKGTTTKKY
     SEGAAAGTED AERAPVEADA GGGQKVLVRN VV