ID   ESPB_MYCTO              Reviewed;         460 AA.
AC   P9WJD8; L0TH12; Q933K8;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=ESX-1 secretion-associated protein EspB {ECO:0000250|UniProtKB:P9WJD9};
DE   AltName: Full=Antigen MTB48 {ECO:0000250|UniProtKB:P9WJD9};
GN   Name=espB {ECO:0000250|UniProtKB:P9WJD9};
GN   Synonyms=mtb48 {ECO:0000250|UniProtKB:P9WJD9}; OrderedLocusNames=MT3996;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WJD9}.
CC       Note=Secreted via the ESX-1 / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WJD9}.
CC   -!- PTM: Cleaved in the C-terminal region by MycP1.
CC       {ECO:0000250|UniProtKB:P9WJD9}.
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DR   EMBL; AE000516; AAK48364.1; -; Genomic_DNA.
DR   PIR; G70803; G70803.
DR   RefSeq; WP_003399995.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WJD8; -.
DR   SMR; P9WJD8; -.
DR   EnsemblBacteria; AAK48364; AAK48364; MT3996.
DR   GeneID; 45427884; -.
DR   KEGG; mtc:MT3996; -.
DR   PATRIC; fig|83331.31.peg.4300; -.
DR   HOGENOM; CLU_039721_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.20.1260.20; -; 1.
DR   InterPro; IPR041275; EspB_PE.
DR   InterPro; IPR038332; PPE_sf.
DR   Pfam; PF18625; EspB_PE; 1.
PE   3: Inferred from homology;
KW   Secreted.
FT   CHAIN           1..460
FT                   /note="ESX-1 secretion-associated protein EspB"
FT                   /id="PRO_0000427847"
FT   REGION          92..116
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          303..335
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          405..441
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   SITE            358..359
FT                   /note="Cleavage; by MycP1"
FT                   /evidence="ECO:0000250|UniProtKB:P9WJD9"
FT   SITE            386..387
FT                   /note="Cleavage; by MycP1"
FT                   /evidence="ECO:0000250|UniProtKB:P9WJD9"
SQ   SEQUENCE   460 AA;  47594 MW;  7528743226AD7A71 CRC64;
     MTQSQTVTVD QQEILNRANE VEAPMADPPT DVPITPCELT AAKNAAQQLV LSADNMREYL
     AAGAKERQRL ATSLRNAAKA YGEVDEEAAT ALDNDGEGTV QAESAGAVGG DSSAELTDTP
     RVATAGEPNF MDLKEAARKL ETGDQGASLA HFADGWNTFN LTLQGDVKRF RGFDNWEGDA
     ATACEASLDQ QRQWILHMAK LSAAMAKQAQ YVAQLHVWAR REHPTYEDIV GLERLYAENP
     SARDQILPVY AEYQQRSEKV LTEYNNKAAL EPVNPPKPPP AIKIDPPPPP QEQGLIPGFL
     MPPSDGSGVT PGTGMPAAPM VPPTGSPGGG LPADTAAQLT SAGREAAALS GDVAVKAASL
     GGGGGGGVPS APLGSAIGGA ESVRPAGAGD IAGLGQGRAG GGAALGGGGM GMPMGAAHQG
     QGGAKSKGSQ QEDEALYTED RAWTEAVIGN RRRQDSKESK