ID   ESPC_MYCTO              Reviewed;         103 AA.
AC   P9WJD6; L0TD21; O06268; P65087;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=ESX-1 secretion-associated protein EspC {ECO:0000250|UniProtKB:P9WJD7};
GN   Name=espC {ECO:0000250|UniProtKB:P9WJD7}; Synonyms=snm9;
GN   OrderedLocusNames=MT3717;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for ESX-1 function. Required for either stability or
CC       expression of EspA. {ECO:0000250|UniProtKB:P9WJD7}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WJD7}.
CC       Note=Secreted via the ESX-1 / type VII secretion system (T7SS).
CC       {ECO:0000250|UniProtKB:P9WJD7}.
CC   -!- DOMAIN: The C-terminal region is required for secretion by the ESX-1
CC       system. {ECO:0000250|UniProtKB:P9WJD7}.
CC   -!- SIMILARITY: Belongs to the EspC family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48076.1; -; Genomic_DNA.
DR   PIR; H70956; H70956.
DR   RefSeq; WP_003899599.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJD6; -.
DR   SMR; P9WJD6; -.
DR   EnsemblBacteria; AAK48076; AAK48076; MT3717.
DR   GeneID; 45427601; -.
DR   KEGG; mtc:MT3717; -.
DR   PATRIC; fig|83331.31.peg.4001; -.
DR   HOGENOM; CLU_177726_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0009306; P:protein secretion; IEA:InterPro.
DR   InterPro; IPR022536; EspC.
DR   Pfam; PF10824; T7SS_ESX_EspC; 1.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..103
FT                   /note="ESX-1 secretion-associated protein EspC"
FT                   /id="PRO_0000427848"
SQ   SEQUENCE   103 AA;  10795 MW;  282161E5D41D53EE CRC64;
     MTENLTVQPE RLGVLASHHD NAAVDASSGV EAAAGLGESV AITHGPYCSQ FNDTLNVYLT
     AHNALGSSLH TAGVDLAKSL RIAAKIYSEA DEAWRKAIDG LFT