ID   ESPD_MYCTO              Reviewed;         184 AA.
AC   P9WJD4; L0TEQ0; O06269; Q7D573;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 37.
DE   RecName: Full=ESX-1 secretion-associated protein EspD {ECO:0000250|UniProtKB:P9WJD5};
GN   Name=espD {ECO:0000250|UniProtKB:P9WJD5}; Synonyms=snm10;
GN   OrderedLocusNames=MT3716;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Required for ESX-1 function. Required for the maintenance of
CC       adequate cellular levels of both EspA and EspC. Facilitates EsxA
CC       secretion. {ECO:0000250|UniProtKB:P9WJD5}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WJD5}.
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DR   EMBL; AE000516; AAK48075.1; -; Genomic_DNA.
DR   PIR; G70956; G70956.
DR   RefSeq; WP_003419545.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJD4; -.
DR   SMR; P9WJD4; -.
DR   EnsemblBacteria; AAK48075; AAK48075; MT3716.
DR   GeneID; 45427600; -.
DR   KEGG; mtc:MT3716; -.
DR   PATRIC; fig|83331.31.peg.4000; -.
DR   HOGENOM; CLU_108891_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Secreted; Virulence.
FT   CHAIN           1..184
FT                   /note="ESX-1 secretion-associated protein EspD"
FT                   /id="PRO_0000427849"
FT   REGION          33..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   184 AA;  19835 MW;  6326911F65DC5C7A CRC64;
     MDLPGNDFDS NDFDAVDLWG ADGAEGWTAD PIIGVGSAAT PDTGPDLDNA HGQAETDTEQ
     EIALFTVTNP PRTVSVSTLM DGRIDHVELS ARVAWMSESQ LASEILVIAD LARQKAQSAQ
     YAFILDRMSQ QVDADEHRVA LLRKTVGETW GLPSPEEAAA AEAEVFATRY SDDCPAPDDE
     SDPW