ID   ESPE_MYCTO              Reviewed;         402 AA.
AC   P9WJD2; L0TDS9; P96213; Q7D4P9;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=ESX-1 secretion-associated protein EspE {ECO:0000250|UniProtKB:P9WJD3};
GN   Name=espE; OrderedLocusNames=MT3978;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000255}.
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DR   EMBL; AE000516; AAK48347.1; -; Genomic_DNA.
DR   PIR; E70656; E70656.
DR   RefSeq; WP_003899736.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJD2; -.
DR   EnsemblBacteria; AAK48347; AAK48347; MT3978.
DR   KEGG; mtc:MT3978; -.
DR   PATRIC; fig|83331.31.peg.4279; -.
DR   HOGENOM; CLU_037846_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   InterPro; IPR043796; ESX-1_EspA/EspE-like.
DR   Pfam; PF18879; EspA_EspE; 1.
PE   3: Inferred from homology;
KW   Cell membrane; Membrane; Transmembrane; Transmembrane helix.
FT   CHAIN           1..402
FT                   /note="ESX-1 secretion-associated protein EspE"
FT                   /id="PRO_0000427850"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   REGION          345..402
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        345..366
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        367..382
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   402 AA;  42069 MW;  B400E0E22D482765 CRC64;
     MASGSGLCKT TSNFIWGQLL LLGEGIPDPG DIFNTGSSLF KQISDKMGLA IPGTNWIGQA
     AEAYLNQNIA QQLRAQVMGD LDKLTGNMIS NQAKYVSDTR DVLRAMKKMI DGVYKVCKGL
     EKIPLLGHLW SWELAIPMSG IAMAVVGGAL LYLTIMTLMN ATNLRGILGR LIEMLTTLPK
     FPGLPGLPSL PDIIDGLWPP KLPDIPIPGL PDIPGLPDFK WPPTPGSPLF PDLPSFPGFP
     GFPEFPAIPG FPALPGLPSI PNLFPGLPGL GDLLPGVGDL GKLPTWTELA ALPDFLGGFA
     GLPSLGFGNL LSFASLPTVG QVTATMGQLQ QLVAAGGGPS QLASMGSQQA QLISSQAQQG
     GQQHATLVSD KKEDEEGVAE AERAPIDAGT AASQRGQEGT VL