AGRF1_HUMAN
ID AGRF1_HUMAN Reviewed; 910 AA.
AC Q5T601; Q5KU15; Q5T5Z9; Q5T600; Q86SM1; Q8IXE3; Q8IZF8; Q96DQ1; Q9H615;
DT 01-MAR-2005, integrated into UniProtKB/Swiss-Prot.
DT 10-AUG-2010, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Adhesion G-protein coupled receptor F1 {ECO:0000303|PubMed:25713288};
DE AltName: Full=G protein-coupled receptor 110;
DE AltName: Full=G protein-coupled receptor KPG_012;
DE AltName: Full=G protein-coupled receptor PGR19;
DE Flags: Precursor;
GN Name=ADGRF1 {ECO:0000312|HGNC:HGNC:18990}; Synonyms=GPR110, PGR19;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RA Okazaki H., Inoue S., Yoshida S., Urakawa I., Mizutani S.;
RT "Probable G-protein coupled receptor KPG_012.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 310-613 (ISOFORM 1).
RC TISSUE=Small intestine, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 198-910 (ISOFORM 1).
RX PubMed=12435584; DOI=10.1016/s0014-5793(02)03574-3;
RA Fredriksson R., Lagerstroem M.C., Hoeglund P.J., Schioeth H.B.;
RT "Novel human G protein-coupled receptors with long N-terminals containing
RT GPS domains and Ser/Thr-rich regions.";
RL FEBS Lett. 531:407-414(2002).
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 460-636 (ISOFORM 1).
RX PubMed=12679517; DOI=10.1073/pnas.0230374100;
RA Vassilatis D.K., Hohmann J.G., Zeng H., Li F., Ranchalis J.E.,
RA Mortrud M.T., Brown A., Rodriguez S.S., Weller J.R., Wright A.C.,
RA Bergmann J.E., Gaitanaris G.A.;
RT "The G protein-coupled receptor repertoires of human and mouse.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:4903-4908(2003).
RN [9]
RP TISSUE SPECIFICITY, SUBCELLULAR LOCATION, AND GLYCOSYLATION.
RX PubMed=20149256; DOI=10.1186/1471-2407-10-40;
RA Lum A.M., Wang B.B., Beck-Engeser G.B., Li L., Channa N., Wabl M.;
RT "Orphan receptor GPR110, an oncogene overexpressed in lung and prostate
RT cancer.";
RL BMC Cancer 10:40-40(2010).
RN [10]
RP NOMENCLATURE.
RX PubMed=25713288; DOI=10.1124/pr.114.009647;
RA Hamann J., Aust G., Arac D., Engel F.B., Formstone C., Fredriksson R.,
RA Hall R.A., Harty B.L., Kirchhoff C., Knapp B., Krishnan A., Liebscher I.,
RA Lin H.H., Martinelli D.C., Monk K.R., Peeters M.C., Piao X., Promel S.,
RA Schoneberg T., Schwartz T.W., Singer K., Stacey M., Ushkaryov Y.A.,
RA Vallon M., Wolfrum U., Wright M.W., Xu L., Langenhan T., Schioth H.B.;
RT "International union of basic and clinical pharmacology. XCIV. Adhesion G
RT protein-coupled receptors.";
RL Pharmacol. Rev. 67:338-367(2015).
CC -!- FUNCTION: Orphan receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:20149256};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- SUBCELLULAR LOCATION: [Isoform 2]: Secreted
CC {ECO:0000269|PubMed:20149256}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5T601-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5T601-2; Sequence=VSP_039588, VSP_039589;
CC -!- TISSUE SPECIFICITY: Mainly expressed in the kidney. Up-regulated in
CC lung adenocarcinomas and prostate cancers.
CC {ECO:0000269|PubMed:20149256}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:20149256}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB70874.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB70874.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};
CC Sequence=BAC45260.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAI13873.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AB065679; BAC45260.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AB045123; BAD83599.1; -; mRNA.
DR EMBL; AK026337; BAB15452.1; -; mRNA.
DR EMBL; AK055208; BAB70874.1; ALT_SEQ; mRNA.
DR EMBL; AL355518; CAI13873.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL355518; CAI13874.1; -; Genomic_DNA.
DR EMBL; AL355518; CAI13875.1; -; Genomic_DNA.
DR EMBL; CH471081; EAX04311.1; -; Genomic_DNA.
DR EMBL; BC113634; AAI13635.1; -; mRNA.
DR EMBL; BC113636; AAI13637.1; -; mRNA.
DR EMBL; AY140952; AAN46666.1; -; mRNA.
DR EMBL; AY255595; AAO85107.1; -; mRNA.
DR CCDS; CCDS34471.1; -. [Q5T601-1]
DR CCDS; CCDS4920.1; -. [Q5T601-2]
DR RefSeq; NP_079324.2; NM_025048.3. [Q5T601-2]
DR RefSeq; NP_722582.2; NM_153840.3. [Q5T601-1]
DR AlphaFoldDB; Q5T601; -.
DR SMR; Q5T601; -.
DR BioGRID; 129353; 100.
DR STRING; 9606.ENSP00000360299; -.
DR ChEMBL; CHEMBL4523872; -.
DR MEROPS; P02.022; -.
DR MEROPS; P02.026; -.
DR GlyGen; Q5T601; 19 sites.
DR iPTMnet; Q5T601; -.
DR PhosphoSitePlus; Q5T601; -.
DR BioMuta; ADGRF1; -.
DR DMDM; 302393689; -.
DR EPD; Q5T601; -.
DR jPOST; Q5T601; -.
DR MassIVE; Q5T601; -.
DR PaxDb; Q5T601; -.
DR PeptideAtlas; Q5T601; -.
DR PRIDE; Q5T601; -.
DR ProteomicsDB; 64561; -. [Q5T601-1]
DR ProteomicsDB; 64562; -. [Q5T601-2]
DR Antibodypedia; 30773; 195 antibodies from 26 providers.
DR DNASU; 266977; -.
DR Ensembl; ENST00000371243.2; ENSP00000360289.2; ENSG00000153292.16. [Q5T601-2]
DR Ensembl; ENST00000371253.7; ENSP00000360299.2; ENSG00000153292.16. [Q5T601-1]
DR GeneID; 266977; -.
DR KEGG; hsa:266977; -.
DR MANE-Select; ENST00000371253.7; ENSP00000360299.2; NM_153840.4; NP_722582.2.
DR UCSC; uc003oyt.4; human. [Q5T601-1]
DR CTD; 266977; -.
DR DisGeNET; 266977; -.
DR GeneCards; ADGRF1; -.
DR HGNC; HGNC:18990; ADGRF1.
DR HPA; ENSG00000153292; Group enriched (esophagus, kidney, urinary bladder).
DR MIM; 617430; gene.
DR neXtProt; NX_Q5T601; -.
DR OpenTargets; ENSG00000153292; -.
DR PharmGKB; PA128394769; -.
DR VEuPathDB; HostDB:ENSG00000153292; -.
DR eggNOG; KOG4193; Eukaryota.
DR GeneTree; ENSGT00940000161228; -.
DR InParanoid; Q5T601; -.
DR OMA; TQFLSTE; -.
DR OrthoDB; 611778at2759; -.
DR PhylomeDB; Q5T601; -.
DR TreeFam; TF316380; -.
DR PathwayCommons; Q5T601; -.
DR BioGRID-ORCS; 266977; 8 hits in 1069 CRISPR screens.
DR ChiTaRS; ADGRF1; human.
DR GeneWiki; GPR110; -.
DR GenomeRNAi; 266977; -.
DR Pharos; Q5T601; Tbio.
DR PRO; PR:Q5T601; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q5T601; protein.
DR Bgee; ENSG00000153292; Expressed in palpebral conjunctiva and 95 other tissues.
DR ExpressionAtlas; Q5T601; baseline and differential.
DR Genevisible; Q5T601; HS.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; TAS:GDB.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0004949; F:cannabinoid receptor activity; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; TAS:GDB.
DR GO; GO:0007613; P:memory; IEA:Ensembl.
DR GO; GO:0031175; P:neuron projection development; IBA:GO_Central.
DR GO; GO:0032793; P:positive regulation of CREB transcription factor activity; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IBA:GO_Central.
DR Gene3D; 2.60.220.50; -; 1.
DR InterPro; IPR046338; GAIN_dom_sf.
DR InterPro; IPR017981; GPCR_2-like.
DR InterPro; IPR008078; GPCR_2_Ig-hepta-like_rcpt.
DR InterPro; IPR000832; GPCR_2_secretin-like.
DR InterPro; IPR000203; GPS.
DR InterPro; IPR000082; SEA_dom.
DR Pfam; PF00002; 7tm_2; 1.
DR Pfam; PF01825; GPS; 1.
DR Pfam; PF01390; SEA; 1.
DR PRINTS; PR00249; GPCRSECRETIN.
DR PRINTS; PR01695; IGHEPTARCPTR.
DR SMART; SM00303; GPS; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR PROSITE; PS50221; GPS; 1.
DR PROSITE; PS50024; SEA; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cell membrane; G-protein coupled receptor;
KW Glycoprotein; Membrane; Receptor; Reference proteome; Secreted; Signal;
KW Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..19
FT /evidence="ECO:0000255"
FT CHAIN 20..910
FT /note="Adhesion G-protein coupled receptor F1"
FT /id="PRO_0000012891"
FT TOPO_DOM 20..590
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 591..611
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 612..624
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 625..645
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 646..660
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 661..681
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 682..699
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 700..720
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 721..744
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 745..765
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 766..791
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT TRANSMEM 792..812
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 813..820
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 821..841
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 842..910
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT DOMAIN 148..256
FT /note="SEA"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00188"
FT DOMAIN 531..578
FT /note="GPS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT CARBOHYD 139
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 168
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 282
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 317
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 329
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 354
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 368
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 410
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 423
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 437
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 455
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 512
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 528
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 553
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 736
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 739
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 205..218
FT /note="NGSIVAGYEVVGSS -> MSLLSPKLECNGTI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039588"
FT VAR_SEQ 219..910
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_039589"
FT VARIANT 787
FT /note="I -> V (in dbSNP:rs1226475)"
FT /id="VAR_055928"
FT CONFLICT 23
FT /note="G -> GV (in Ref. 4; CAI13874)"
FT /evidence="ECO:0000305"
FT CONFLICT 27
FT /note="G -> D (in Ref. 3; BAB15452)"
FT /evidence="ECO:0000305"
FT CONFLICT 198..203
FT /note="VQVTQF -> MDISIQ (in Ref. 7; AAN46666)"
FT /evidence="ECO:0000305"
FT CONFLICT 614
FT /note="I -> A (in Ref. 3; BAB70874)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 910 AA; 101365 MW; 07B5234A487E9F07 CRC64;
MKVGVLWLIS FFTFTDGHGG FLGKNDGIKT KKELIVNKKK HLGPVEEYQL LLQVTYRDSK
EKRDLRNFLK LLKPPLLWSH GLIRIIRAKA TTDCNSLNGV LQCTCEDSYT WFPPSCLDPQ
NCYLHTAGAL PSCECHLNNL SQSVNFCERT KIWGTFKINE RFTNDLLNSS SAIYSKYANG
IEIQLKKAYE RIQGFESVQV TQFRNGSIVA GYEVVGSSSA SELLSAIEHV AEKAKTALHK
LFPLEDGSFR VFGKAQCNDI VFGFGSKDDE YTLPCSSGYR GNITAKCESS GWQVIRETCV
LSLLEELNKN FSMIVGNATE AAVSSFVQNL SVIIRQNPST TVGNLASVVS ILSNISSLSL
ASHFRVSNST MEDVISIADN ILNSASVTNW TVLLREEKYA SSRLLETLEN ISTLVPPTAL
PLNFSRKFID WKGIPVNKSQ LKRGYSYQIK MCPQNTSIPI RGRVLIGSDQ FQRSLPETII
SMASLTLGNI LPVSKNGNAQ VNGPVISTVI QNYSINEVFL FFSKIESNLS QPHCVFWDFS
HLQWNDAGCH LVNETQDIVT CQCTHLTSFS ILMSPFVPST IFPVVKWITY VGLGISIGSL
ILCLIIEALF WKQIKKSQTS HTRRICMVNI ALSLLIADVW FIVGATVDTT VNPSGVCTAA
VFFTHFFYLS LFFWMLMLGI LLAYRIILVF HHMAQHLMMA VGFCLGYGCP LIISVITIAV
TQPSNTYKRK DVCWLNWSNG SKPLLAFVVP ALAIVAVNFV VVLLVLTKLW RPTVGERLSR
DDKATIIRVG KSLLILTPLL GLTWGFGIGT IVDSQNLAWH VIFALLNAFQ GFFILCFGIL
LDSKLRQLLF NKLSALSSWK QTEKQNSSDL SAKPKFSKPF NPLQNKGHYA FSHTGDSSDN
IMLTQFVSNE
