ID   ESPG2_MYCTO             Reviewed;         276 AA.
AC   P9WJC8; L0TDV4; O05455; Q7D4N6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=ESX-2 secretion-associated protein EspG2 {ECO:0000305};
GN   Name=espG2 {ECO:0000250|UniProtKB:P9WJC9}; OrderedLocusNames=MT4004;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Specific chaperone for cognate PE/PPE proteins. Plays an
CC       important role in preventing aggregation of PE/PPE dimers.
CC       {ECO:0000250|UniProtKB:O53943}.
CC   -!- SUBUNIT: Interacts specifically with ESX-2-dependent PE/PPE proteins.
CC       {ECO:0000250|UniProtKB:O53943}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2HSU5}.
CC   -!- SIMILARITY: Belongs to the EspG family. {ECO:0000305}.
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DR   EMBL; AE000516; AAK48371.1; -; Genomic_DNA.
DR   PIR; B70598; B70598.
DR   RefSeq; WP_003400028.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WJC8; -.
DR   SMR; P9WJC8; -.
DR   EnsemblBacteria; AAK48371; AAK48371; MT4004.
DR   GeneID; 45427892; -.
DR   KEGG; mtc:MT4004; -.
DR   PATRIC; fig|83331.31.peg.4311; -.
DR   HOGENOM; CLU_085037_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025734; EspG.
DR   Pfam; PF14011; ESX-1_EspG; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm.
FT   CHAIN           1..276
FT                   /note="ESX-2 secretion-associated protein EspG2"
FT                   /id="PRO_0000427852"
SQ   SEQUENCE   276 AA;  29596 MW;  CC698D02401DA59B CRC64;
     MLTTTVDGLW VLQAVTGVEQ TCPELGLRPL LPRLDTAERA LRHPVAAELM AVGALDQAGN
     ADPMVREWLT VLLRRDLGLL VTIGVPGGEP TRAAICRFAT WWVVLERHGN LVRLYPAGTA
     SDEAGAGELV VGQVERLCGV AEAAPLRPVT VDADELLHAV RDAGTLRSYL LSQRLDVDQL
     QMVTMAADPT RSAHATLVAL QAGVGPEKSA RILVGDSTVA IVDTAAGRIC VESVTSGQRR
     YQVLSPGSRS DIGGAVQRLI RRLPAGDEWY SYRRVV