ID   ESPG2_MYCTU             Reviewed;         276 AA.
AC   P9WJC9; L0TDV4; O05455; Q7D4N6;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 32.
DE   RecName: Full=ESX-2 secretion-associated protein EspG2 {ECO:0000305};
GN   Name=espG2 {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv3889c;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   NOMENCLATURE.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
CC   -!- FUNCTION: Specific chaperone for cognate PE/PPE proteins. Plays an
CC       important role in preventing aggregation of PE/PPE dimers.
CC       {ECO:0000250|UniProtKB:O53943}.
CC   -!- SUBUNIT: Interacts specifically with ESX-2-dependent PE/PPE proteins.
CC       {ECO:0000250|UniProtKB:O53943}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2HSU5}.
CC   -!- SIMILARITY: Belongs to the EspG family. {ECO:0000305}.
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DR   EMBL; AL123456; CCP46718.1; -; Genomic_DNA.
DR   PIR; B70598; B70598.
DR   RefSeq; NP_218406.1; NC_000962.3.
DR   RefSeq; WP_003400028.1; NZ_NVQJ01000005.1.
DR   AlphaFoldDB; P9WJC9; -.
DR   SMR; P9WJC9; -.
DR   STRING; 83332.Rv3889c; -.
DR   PaxDb; P9WJC9; -.
DR   DNASU; 886223; -.
DR   GeneID; 45427892; -.
DR   GeneID; 886223; -.
DR   KEGG; mtu:Rv3889c; -.
DR   TubercuList; Rv3889c; -.
DR   eggNOG; ENOG5030RDF; Bacteria.
DR   OMA; ICVENVM; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR025734; EspG.
DR   Pfam; PF14011; ESX-1_EspG; 1.
PE   3: Inferred from homology;
KW   Chaperone; Cytoplasm; Reference proteome.
FT   CHAIN           1..276
FT                   /note="ESX-2 secretion-associated protein EspG2"
FT                   /id="PRO_0000394153"
SQ   SEQUENCE   276 AA;  29596 MW;  CC698D02401DA59B CRC64;
     MLTTTVDGLW VLQAVTGVEQ TCPELGLRPL LPRLDTAERA LRHPVAAELM AVGALDQAGN
     ADPMVREWLT VLLRRDLGLL VTIGVPGGEP TRAAICRFAT WWVVLERHGN LVRLYPAGTA
     SDEAGAGELV VGQVERLCGV AEAAPLRPVT VDADELLHAV RDAGTLRSYL LSQRLDVDQL
     QMVTMAADPT RSAHATLVAL QAGVGPEKSA RILVGDSTVA IVDTAAGRIC VESVTSGQRR
     YQVLSPGSRS DIGGAVQRLI RRLPAGDEWY SYRRVV