ID   088R_FRG3G              Reviewed;         150 AA.
AC   Q6GZN7;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   12-AUG-2020, entry version 50.
DE   RecName: Full=Putative FAD-linked sulfhydryl oxidase 088R;
DE            EC=1.8.3.2;
GN   ORFNames=FV3-088R;
OS   Frog virus 3 (isolate Goorha) (FV-3).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Megaviricetes;
OC   Pimascovirales; Iridoviridae; Alphairidovirinae; Ranavirus.
OX   NCBI_TaxID=654924;
OH   NCBI_TaxID=30343; Dryophytes versicolor (chameleon treefrog).
OH   NCBI_TaxID=8404; Lithobates pipiens (Northern leopard frog) (Rana pipiens).
OH   NCBI_TaxID=45438; Lithobates sylvaticus (Wood frog) (Rana sylvatica).
OH   NCBI_TaxID=8316; Notophthalmus viridescens (Eastern newt) (Triturus viridescens).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15165820; DOI=10.1016/j.virol.2004.02.019;
RA   Tan W.G., Barkman T.J., Gregory Chinchar V., Essani K.;
RT   "Comparative genomic analyses of frog virus 3, type species of the genus
RT   Ranavirus (family Iridoviridae).";
RL   Virology 323:70-84(2004).
CC   -!- FUNCTION: FAD-dependent sulfhydryl oxidase that catalyzes disulfide
CC       bond formation. {ECO:0000255|PROSITE-ProRule:PRU00654}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=O2 + 2 R'C(R)SH = H2O2 + R'C(R)S-S(R)CR';
CC         Xref=Rhea:RHEA:17357, ChEBI:CHEBI:15379, ChEBI:CHEBI:16240,
CC         ChEBI:CHEBI:16520, ChEBI:CHEBI:17412; EC=1.8.3.2;
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000255|PROSITE-ProRule:PRU00654};
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DR   EMBL; AY548484; AAT09748.1; -; Genomic_DNA.
DR   RefSeq; YP_031667.1; NC_005946.1.
DR   SMR; Q6GZN7; -.
DR   GeneID; 2947807; -.
DR   KEGG; vg:2947807; -.
DR   Proteomes; UP000008770; Genome.
DR   GO; GO:0016972; F:thiol oxidase activity; IEA:UniProtKB-EC.
DR   Gene3D; 1.20.120.310; -; 1.
DR   InterPro; IPR036774; ERV/ALR_sulphydryl_oxid_sf.
DR   InterPro; IPR017905; ERV/ALR_sulphydryl_oxidase.
DR   Pfam; PF04777; Evr1_Alr; 1.
DR   SUPFAM; SSF69000; SSF69000; 1.
DR   PROSITE; PS51324; ERV_ALR; 1.
PE   3: Inferred from homology;
KW   Disulfide bond; FAD; Flavoprotein; Oxidoreductase; Reference proteome.
FT   CHAIN           1..150
FT                   /note="Putative FAD-linked sulfhydryl oxidase 088R"
FT                   /id="PRO_0000410589"
FT   DOMAIN          24..128
FT                   /note="ERV/ALR sulfhydryl oxidase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00654"
FT   DISULFID        74..77
FT                   /note="Redox-active"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00654"
SQ   SEQUENCE   150 AA;  16507 MW;  AEAAA3A32EFE5EC2 CRC64;
     MHGCNCNRVS GHLSAVRSSG LENGPFGPSG FGPSMWFTMH SGAAERAIRG GYLTENEKAA
     WESWLRNLWV CIPCESCRRH YMGIVNAVDF GSVNTGDKVF RLTVDIHNMV NARLNKPHVT
     LQKAICIYGL DTKLGPASTI TFRANTSTFN