ESPG3_MYCTO
ID ESPG3_MYCTO Reviewed; 295 AA.
AC P9WJC6; L0T4X8; O53694; Q7DA33;
DT 16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=ESX-3 secretion-associated protein EspG3 {ECO:0000305};
GN Name=espG3 {ECO:0000250|UniProtKB:P9WJC7}; OrderedLocusNames=MT0302;
OS Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC Mycobacterium; Mycobacterium tuberculosis complex.
OX NCBI_TaxID=83331;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CDC 1551 / Oshkosh;
RX PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT laboratory strains.";
RL J. Bacteriol. 184:5479-5490(2002).
CC -!- FUNCTION: Specific chaperone for cognate PE/PPE proteins. Plays an
CC important role in preventing aggregation of PE/PPE dimers.
CC {ECO:0000250|UniProtKB:O53943}.
CC -!- SUBUNIT: Interacts specifically with ESX-3-dependent PE/PPE proteins.
CC {ECO:0000250|UniProtKB:O53943}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:B2HSU5}.
CC -!- SIMILARITY: Belongs to the EspG family. {ECO:0000305}.
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DR EMBL; AE000516; AAK44526.1; -; Genomic_DNA.
DR PIR; G70836; G70836.
DR RefSeq; WP_003401521.1; NZ_KK341227.1.
DR AlphaFoldDB; P9WJC6; -.
DR SASBDB; P9WJC6; -.
DR SMR; P9WJC6; -.
DR EnsemblBacteria; AAK44526; AAK44526; MT0302.
DR GeneID; 45424263; -.
DR KEGG; mtc:MT0302; -.
DR PATRIC; fig|83331.31.peg.325; -.
DR HOGENOM; CLU_073321_0_0_11; -.
DR Proteomes; UP000001020; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR InterPro; IPR025734; EspG.
DR Pfam; PF14011; ESX-1_EspG; 1.
PE 3: Inferred from homology;
KW Chaperone; Cytoplasm.
FT CHAIN 1..295
FT /note="ESX-3 secretion-associated protein EspG3"
FT /id="PRO_0000427853"
SQ SEQUENCE 295 AA; 31559 MW; B55062E063E944D7 CRC64;
MDATPNAVEL TVDNAWFIAE TIGAGTFPWV LAITMPYSDA AQRGAFVDRQ RDELTRMGLL
SPQGVINPAV ADWIKVVCFP DRWLDLRYVG PASADGACEL LRGIVALRTG TGKTSNKTGN
GVVALRNAQL VTFTAMDIDD PRALVPILGV GLAHRPPARF DEFSLPTRVG ARADERLRSG
VPLGEVVDYL GIPASARPVV ESVFSGPRSY VEIVAGCNRD GRHTTTEVGL SIVDTSAGRV
LVSPSRAFDG EWVSTFSPGT PFAIAVAIQT LTACLPDGQW FPGQRVSRDF STQSS