ID   ESPH_MYCTU              Reviewed;         183 AA.
AC   O69732; L0TGU5;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=ESX-1 secretion-associated protein EspH {ECO:0000305};
GN   Name=espH {ECO:0000303|PubMed:19876390}; OrderedLocusNames=Rv3867;
OS   Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83332;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=9634230; DOI=10.1038/31159;
RA   Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C.M., Harris D.E.,
RA   Gordon S.V., Eiglmeier K., Gas S., Barry C.E. III, Tekaia F., Badcock K.,
RA   Basham D., Brown D., Chillingworth T., Connor R., Davies R.M., Devlin K.,
RA   Feltwell T., Gentles S., Hamlin N., Holroyd S., Hornsby T., Jagels K.,
RA   Krogh A., McLean J., Moule S., Murphy L.D., Oliver S., Osborne J.,
RA   Quail M.A., Rajandream M.A., Rogers J., Rutter S., Seeger K., Skelton S.,
RA   Squares S., Squares R., Sulston J.E., Taylor K., Whitehead S.,
RA   Barrell B.G.;
RT   "Deciphering the biology of Mycobacterium tuberculosis from the complete
RT   genome sequence.";
RL   Nature 393:537-544(1998).
RN   [2]
RP   DISRUPTION PHENOTYPE.
RX   PubMed=16368961; DOI=10.1128/iai.74.1.88-98.2006;
RA   Brodin P., Majlessi L., Marsollier L., de Jonge M.I., Bottai D.,
RA   Demangel C., Hinds J., Neyrolles O., Butcher P.D., Leclerc C., Cole S.T.,
RA   Brosch R.;
RT   "Dissection of ESAT-6 system 1 of Mycobacterium tuberculosis and impact on
RT   immunogenicity and virulence.";
RL   Infect. Immun. 74:88-98(2006).
RN   [3]
RP   GENE NAME.
RX   PubMed=19876390; DOI=10.1371/journal.ppat.1000507;
RA   Bitter W., Houben E.N., Bottai D., Brodin P., Brown E.J., Cox J.S.,
RA   Derbyshire K., Fortune S.M., Gao L.Y., Liu J., Gey van Pittius N.C.,
RA   Pym A.S., Rubin E.J., Sherman D.R., Cole S.T., Brosch R.;
RT   "Systematic genetic nomenclature for type VII secretion systems.";
RL   PLoS Pathog. 5:E1000507-E1000507(2009).
RN   [4]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   STRAIN=ATCC 25618 / H37Rv;
RX   PubMed=21969609; DOI=10.1074/mcp.m111.011627;
RA   Kelkar D.S., Kumar D., Kumar P., Balakrishnan L., Muthusamy B., Yadav A.K.,
RA   Shrivastava P., Marimuthu A., Anand S., Sundaram H., Kingsbury R.,
RA   Harsha H.C., Nair B., Prasad T.S., Chauhan D.S., Katoch K., Katoch V.M.,
RA   Kumar P., Chaerkady R., Ramachandran S., Dash D., Pandey A.;
RT   "Proteogenomic analysis of Mycobacterium tuberculosis by high resolution
RT   mass spectrometry.";
RL   Mol. Cell. Proteomics 10:M111.011627-M111.011627(2011).
CC   -!- DISRUPTION PHENOTYPE: Inactivation does not abolish EsxA (ESAT-6)
CC       secretion, EsxA-specific immunogenicity and enhanced virulence.
CC       {ECO:0000269|PubMed:16368961}.
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DR   EMBL; AL123456; CCP46696.1; -; Genomic_DNA.
DR   PIR; A70802; A70802.
DR   RefSeq; NP_218384.1; NC_000962.3.
DR   RefSeq; WP_003399844.1; NZ_NVQJ01000074.1.
DR   AlphaFoldDB; O69732; -.
DR   SMR; O69732; -.
DR   STRING; 83332.Rv3867; -.
DR   PaxDb; O69732; -.
DR   DNASU; 886203; -.
DR   GeneID; 45427871; -.
DR   GeneID; 886203; -.
DR   KEGG; mtu:Rv3867; -.
DR   TubercuList; Rv3867; -.
DR   eggNOG; ENOG5031M2V; Bacteria.
DR   OMA; QPRSNAH; -.
DR   Proteomes; UP000001584; Chromosome.
DR   GO; GO:0005886; C:plasma membrane; HDA:MTBBASE.
DR   GO; GO:0046677; P:response to antibiotic; IEP:MTBBASE.
DR   GO; GO:0052562; P:suppression by symbiont of host immune response; IDA:MTBBASE.
PE   1: Evidence at protein level;
KW   Reference proteome.
FT   CHAIN           1..183
FT                   /note="ESX-1 secretion-associated protein EspH"
FT                   /id="PRO_0000394146"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..17
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   183 AA;  19946 MW;  1D0F8B9430FAF25D CRC64;
     MVDPPGNDDD HGDLDALDFS AAHTNEASPL DALDDYAPVQ TDDAEGDLDA LHALTERDEE
     PELELFTVTN PQGSVSVSTL MDGRIQHVEL TDKATSMSEA QLADEIFVIA DLARQKARAS
     QYTFMVENIG ELTDEDAEGS ALLREFVGMT LNLPTPEEAA AAEAEVFATR YDVDYTSRYK
     ADD