ID   ESPJ_MYCTO              Reviewed;         280 AA.
AC   P9WJC2; L0TFI6; O69742; Q7D4P1;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 35.
DE   RecName: Full=ESX-1 secretion-associated protein EspJ {ECO:0000250|UniProtKB:P9WJC3};
DE   AltName: Full=TB27.4;
GN   Name=espJ {ECO:0000250|UniProtKB:P9WJC3}; OrderedLocusNames=MT3992;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Could be involved in regulation of growth and intracellular
CC       survival. {ECO:0000250|UniProtKB:P9WJC3}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P9WJC3}.
CC   -!- PTM: Phosphorylated at Ser-70. {ECO:0000250|UniProtKB:P9WJC3}.
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DR   EMBL; AE000516; AAK48360.1; -; Genomic_DNA.
DR   PIR; D70803; D70803.
DR   RefSeq; WP_003899742.1; NZ_KK341228.1.
DR   AlphaFoldDB; P9WJC2; -.
DR   SMR; P9WJC2; -.
DR   EnsemblBacteria; AAK48360; AAK48360; MT3992.
DR   KEGG; mtc:MT3992; -.
DR   PATRIC; fig|83331.31.peg.4295; -.
DR   HOGENOM; CLU_088215_0_0_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Phosphoprotein; Secreted; Virulence.
FT   CHAIN           1..280
FT                   /note="ESX-1 secretion-associated protein EspJ"
FT                   /id="PRO_0000427855"
FT   REGION          167..280
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..186
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         70
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:P9WJC3"
SQ   SEQUENCE   280 AA;  27422 MW;  7E7DC14AEE7CB516 CRC64;
     MAEPLAVDPT GLSAAAAKLA GLVFPQPPAP IAVSGTDSVV AAINETMPSI ESLVSDGLPG
     VKAALTRTAS NMNAAADVYA KTDQSLGTSL SQYAFGSSGE GLAGVASVGG QPSQATQLLS
     TPVSQVTTQL GETAAELAPR VVAKVPQLVQ LAPHAVQMSQ NASPIAQTIS QTAQQAAQSA
     QGGSGPMPAQ LASAEKPATE QAEPVHEVTN DDQGDQGDVQ PAEVVAAARD EGAGASPGQQ
     PGGGVPAQAM DTGAGARPAA SPLAAPVDPS TPAPSTTTTL