位置:首页 > 蛋白库 > AGRF2_MOUSE
AGRF2_MOUSE
ID   AGRF2_MOUSE             Reviewed;         644 AA.
AC   E9Q4J9; B9EJ67;
DT   24-JUN-2015, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   03-AUG-2022, entry version 68.
DE   RecName: Full=Adhesion G-protein coupled receptor F2;
DE   AltName: Full=G-protein coupled receptor 111;
DE   AltName: Full=G-protein coupled receptor PGR20;
DE   Flags: Precursor;
GN   Name=Adgrf2; Synonyms=Gpr111, Pgr20;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [3]
RP   TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=22837050; DOI=10.1002/dvdy.23841;
RA   Promel S., Waller-Evans H., Dixon J., Zahn D., Colledge W.H., Doran J.,
RA   Carlton M.B., Grosse J., Schoneberg T., Russ A.P., Langenhan T.;
RT   "Characterization and functional study of a cluster of four highly
RT   conserved orphan adhesion-GPCR in mouse.";
RL   Dev. Dyn. 241:1591-1602(2012).
CC   -!- FUNCTION: Orphan receptor.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Mainly expressed in skin and heart, and very weakly
CC       in lung and spleen. Detected in all epidermal layers of skin.
CC       {ECO:0000269|PubMed:22837050}.
CC   -!- DEVELOPMENTAL STAGE: Expressed during embryonic development in the skin
CC       starting at embryonic day 12 with the formation of the basal layer of
CC       the skin. {ECO:0000269|PubMed:22837050}.
CC   -!- DISRUPTION PHENOTYPE: No visible phenotype.
CC       {ECO:0000269|PubMed:22837050}.
CC   -!- MISCELLANEOUS: Most adhesion GPCRs undergo autoproteolysis at the GPS
CC       domain. ADGRF2 is not autoproteolyzed at the GPS motif because of the
CC       lack of a consensus catalytic triad sequence within GPS domain.
CC       {ECO:0000269|PubMed:22837050}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 2 family.
CC       Adhesion G-protein coupled receptor (ADGR) subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AC117257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC141353; AAI41354.1; -; mRNA.
DR   CCDS; CCDS28792.2; -.
DR   RefSeq; NP_001028665.2; NM_001033493.2.
DR   AlphaFoldDB; E9Q4J9; -.
DR   SMR; E9Q4J9; -.
DR   STRING; 10090.ENSMUSP00000109244; -.
DR   GlyGen; E9Q4J9; 4 sites.
DR   iPTMnet; E9Q4J9; -.
DR   PhosphoSitePlus; E9Q4J9; -.
DR   jPOST; E9Q4J9; -.
DR   PaxDb; E9Q4J9; -.
DR   PRIDE; E9Q4J9; -.
DR   ProteomicsDB; 296131; -.
DR   Antibodypedia; 30795; 103 antibodies from 22 providers.
DR   DNASU; 435529; -.
DR   Ensembl; ENSMUST00000113614; ENSMUSP00000109244; ENSMUSG00000057899.
DR   GeneID; 435529; -.
DR   KEGG; mmu:435529; -.
DR   UCSC; uc008cos.1; mouse.
DR   CTD; 222611; -.
DR   MGI; MGI:2182728; Adgrf2.
DR   VEuPathDB; HostDB:ENSMUSG00000057899; -.
DR   eggNOG; KOG4193; Eukaryota.
DR   GeneTree; ENSGT00940000162401; -.
DR   HOGENOM; CLU_002753_3_6_1; -.
DR   InParanoid; E9Q4J9; -.
DR   OrthoDB; 611778at2759; -.
DR   PhylomeDB; E9Q4J9; -.
DR   TreeFam; TF316380; -.
DR   BioGRID-ORCS; 435529; 1 hit in 71 CRISPR screens.
DR   ChiTaRS; Adgrf2; mouse.
DR   PRO; PR:E9Q4J9; -.
DR   Proteomes; UP000000589; Chromosome 17.
DR   RNAct; E9Q4J9; protein.
DR   Bgee; ENSMUSG00000057899; Expressed in esophagus and 16 other tissues.
DR   ExpressionAtlas; E9Q4J9; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0007189; P:adenylate cyclase-activating G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR   Gene3D; 2.60.220.50; -; 1.
DR   InterPro; IPR046338; GAIN_dom_sf.
DR   InterPro; IPR017981; GPCR_2-like.
DR   InterPro; IPR000832; GPCR_2_secretin-like.
DR   InterPro; IPR000203; GPS.
DR   Pfam; PF00002; 7tm_2; 1.
DR   Pfam; PF01825; GPS; 1.
DR   PRINTS; PR00249; GPCRSECRETIN.
DR   SMART; SM00303; GPS; 1.
DR   PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
DR   PROSITE; PS50221; GPS; 1.
PE   2: Evidence at transcript level;
KW   Glycoprotein; Membrane; Reference proteome; Signal; Transmembrane;
KW   Transmembrane helix.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   CHAIN           19..644
FT                   /note="Adhesion G-protein coupled receptor F2"
FT                   /id="PRO_0000433228"
FT   TOPO_DOM        19..386
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        387..407
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        408..422
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        423..443
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        444..465
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        466..486
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        487..493
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        494..514
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        515..541
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        542..562
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        563..585
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        586..606
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        607..610
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000305"
FT   TRANSMEM        611..631
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          326..376
FT                   /note="GPS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00098"
FT   CARBOHYD        155
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        219
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        293
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        311
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        341
FT                   /note="W -> R (in Ref. 2; AAI41354)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   644 AA;  71764 MW;  37F13B998F5FAA66 CRC64;
     MIPAHWLYCL MLLLPIESCR ILCQASSKSK EKVTSRPHDV CDGVCNNNGT PCFQSCPPDS
     EGNMKFACKA KKWHKVTETC HTLNTHSIFE EDKELYSVQS SDSTIRTHMF HRELKTIMDT
     LMEKCPKDLS CVIKGIERSP RMPGNIAVVV QLLHNISTTL TKDVNEEKMQ SYSAMANHIL
     NSKSISNWTF IQDRNSSCVL LQSIHSFASK LFMKEHLINI SHVFIHTLGT VVSRGSLGKN
     FTFSMRINET SDKVTGRLLL SPEELQKVPS AFQVISIAFP TLGAILEASL LENVTVNGLV
     LSVILPEELK NISLIFEKIR KSGERKSQCV GWHSLESRWD WRACKTIQEN SRQAVCRCRP
     NKLYTSFSIL MSPNTLESPV LTYITYIGLG ISICSLIICL AIEVLVWSQV TKTEISYLRH
     LCIANIAATL LMADAWFIVA SFLSGPVLHH NGCVAATFFV HFFYLSVFFW MLAKALLILY
     GILIVFHTLP KSCLVASLFS VGYGCPLVIA IITLAVTEPG KGYLRPEACW LNWDMTKALL
     AFVVPALAIV VVNLITVTMV IIKTQRAAIG SSMFQEVRAI VRICKNIAIL TPLLGLTWGF
     GIATVINGHS LAFHIIFSLL NALQVSPDAA VDSELRECVH RFCG
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024