ID   ESPR_MYCTO              Reviewed;         132 AA.
AC   P9WJB6; L0TDR1; P96228; Q8VIS2;
DT   16-APR-2014, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Nucleoid-associated protein EspR {ECO:0000250|UniProtKB:P9WJB7};
GN   Name=espR {ECO:0000250|UniProtKB:P9WJB7}; OrderedLocusNames=MT3964;
OS   Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh).
OC   Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae;
OC   Mycobacterium; Mycobacterium tuberculosis complex.
OX   NCBI_TaxID=83331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CDC 1551 / Oshkosh;
RX   PubMed=12218036; DOI=10.1128/jb.184.19.5479-5490.2002;
RA   Fleischmann R.D., Alland D., Eisen J.A., Carpenter L., White O.,
RA   Peterson J.D., DeBoy R.T., Dodson R.J., Gwinn M.L., Haft D.H., Hickey E.K.,
RA   Kolonay J.F., Nelson W.C., Umayam L.A., Ermolaeva M.D., Salzberg S.L.,
RA   Delcher A., Utterback T.R., Weidman J.F., Khouri H.M., Gill J., Mikula A.,
RA   Bishai W., Jacobs W.R. Jr., Venter J.C., Fraser C.M.;
RT   "Whole-genome comparison of Mycobacterium tuberculosis clinical and
RT   laboratory strains.";
RL   J. Bacteriol. 184:5479-5490(2002).
CC   -!- FUNCTION: Virulence regulator that has both architectural and
CC       regulatory roles. Impacts cell wall functions and pathogenesis through
CC       regulation of multiple genes. {ECO:0000250|UniProtKB:P9WJB7}.
CC   -!- SUBUNIT: Homodimer. Binds DNA as a dimer of dimers.
CC       {ECO:0000250|UniProtKB:P9WJB7}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, nucleoid
CC       {ECO:0000250|UniProtKB:P9WJB7}.
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DR   EMBL; AE000516; AAK48331.1; -; Genomic_DNA.
DR   PIR; F70654; F70654.
DR   RefSeq; WP_003399759.1; NZ_KK341227.1.
DR   AlphaFoldDB; P9WJB6; -.
DR   SMR; P9WJB6; -.
DR   EnsemblBacteria; AAK48331; AAK48331; MT3964.
DR   GeneID; 45427853; -.
DR   KEGG; mtc:MT3964; -.
DR   PATRIC; fig|83331.31.peg.4263; -.
DR   HOGENOM; CLU_127701_2_1_11; -.
DR   Proteomes; UP000001020; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0009295; C:nucleoid; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.260.40; -; 1.
DR   InterPro; IPR001387; Cro/C1-type_HTH.
DR   InterPro; IPR010982; Lambda_DNA-bd_dom_sf.
PE   3: Inferred from homology;
KW   Activator; Cytoplasm; DNA-binding; Repressor; Transcription;
KW   Transcription regulation; Virulence.
FT   CHAIN           1..132
FT                   /note="Nucleoid-associated protein EspR"
FT                   /id="PRO_0000427858"
FT   DNA_BIND        38..50
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   132 AA;  14709 MW;  84EA0DB906D81996 CRC64;
     MSTTFAARLN RLFDTVYPPG RGPHTSAEVI AALKAEGITM SAPYLSQLRS GNRTNPSGAT
     MAALANFFRI KAAYFTDDEY YEKLDKELQW LCTMRDDGVR RIAQRAHGLP SAAQQKVLDR
     IDELRRAEGI DA